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1.11.1.9: glutathione peroxidase

This is an abbreviated version!
For detailed information about glutathione peroxidase, go to the full flat file.

Word Map on EC 1.11.1.9

Reaction

2 glutathione +

H2O2
=
glutathione disulfide
 + 2 H2O

Synonyms

2-SeCD, 3,3'-telluro-bis(proapne-3,1-diyl)adamantane carboxylate, 6P229, ADA-Te-OH, ARMEP24, AtGPX1, ATGPX3, c-GPx4, Cellular glutathione peroxidase, cgd3_460, cGPx, Cuticular glycoprotein GP29, DI29, ebselen, EGLP, Epididymis-specific glutathione peroxidase-like protein, Extracellular glutathione peroxidase, G-6137, Gastrointestinal glutathione peroxidase, glutathione peroxidase 1, glutathione peroxidase 2, glutathione peroxidase 3, glutathione peroxidase 4, glutathione peroxidase Gpx2, glutathione peroxidase Gpx3, glutathione peroxidase-1, glutathione peroxidase-2, glutathione peroxidase-3, glutathione peroxidase-4, glutathione-dependent peroxidase I, glutathione:hydrogen-peroxide oxidoreductase, GP30, GPRP, GPX, Gpx-1, GPx-2, GPx-3, GPx-4, GPx-5, GPx-6, GPx-7, GPx-8, GPX1, Gpx2, GPX3, GPx4, GPX5, GSH peroxidase, GSH-Px, GSHPx, GSHPx-GI, intracellular GpX, m-GPx4, Major androgen-regulated protein, Major surface antigen GP29, n-GPx4, Nt-SubC08, Odorant-metabolizing protein RY2D1, Os02g0664000, OsGPX5, peroxidase, glutathione, PGdx, pGPx, PHGPX, phospholipid glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, nuclear form, phospholipid hydroperoxide Gpx, plasma glutathione peroxidase, prion protein Ure2, reduced glutathione peroxidase, Salt-associated protein, Se-GPx, Se-hGSTZ1-1, Se-scFv-B3, secreted GpX, SeGPx, selenium containing glutathione transferase zeta1-1, selenium-dependent glutathione peroxidase, selenium-glutathione peroxidase, seleno-dependent glutathione peroxidase 1, selenosubtilisin, snGPx, TcGPXI, TTHERM_00046090, TTHERM_00046110, TTHERM_01099010, Ure2

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.9 glutathione peroxidase

Inhibitors

Inhibitors on EC 1.11.1.9 - glutathione peroxidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
2 mM, 23% residual activity
3-deoxyglucosone
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
6-diazo-5-oxo-L-norleucine
-
20 mM, 60% residual activity
adenosine
-
inhibition probably due to inhibition of glutathione reductase in coupled assay
Ag+
-
-
AlCl3
-
10 mM, 67% residual activity
alpha-Mercaptopropionylglycine
-
-
BaCl2
-
10 mM, 52% residual activity
CaCl2
-
10 mM, 81% residual activity
Chloroacetate
-
-
CN-
-
no inhibition if simultaneously incubated with 2-mercaptoethanol, glutathione or dithiothreitol
cysteine
-
GPx-1 is inhibited by 0.5 mM cysteine
diethyldithiocarbamate
-
significant inhibition of selenium-dependent enzyme after intraperitoneal injection of rats with diethyldithiocarbamate, which returns to normal at 48 h after administration of injection. It is possible that inhibition of superoxide dismutase by diethyldithiocarbamate leads to accumulation of superoxide anion which in turn inactivates selenium-dependent glutathione peroxidase by its reaction with slenium at the active site of the enzyme
DL-dithiothreitol
-
2 mM, no residual activity
docosahexaenoic acid
-
0.1 mM reduces the level of protein expression of GPx-4 by at least 50%
DTNB
-
20 mM, 46% residual activity
EDTA
-
1 mM, about 40% residual activity, activity is completely restored upon addition of Se+ cations, followed by Na+
Fe2+
-
2 mM, 21% of initial activity
FeCl3
-
10 mM, 68% residual activity
glutathione
-
-
Glyoxal
-
-
Gold(I)-thioglucose
-
-
HgCl2
-
10 mM, 61% residual activity
homocysteine
-
GPx-1 is inhibited by 0.05-0.5 mM homocysteine, especially at low glutathione concentrations
hydroxylamine
-
20 mM, 25% residual activity
iodoacetamide
iodoacetate
KCl
-
10 mM, 45% residual activity
MBTH
-
20 mM, 59% residual activity
Mercaptosuccinate
methylglyoxal
-
Arg184 and Arg185, located in the glutathione binding site of the enzyme are irreversibly modified by treatment with methylglyoxal
MgSO4
-
10 mM, 58% residual activity
NADPH
-
inhibition probably due to inhibition of glutathione reductase in coupled assay
p-chloromercuribenzoate
-
-
Penicillamine
-
-
Phenanthroline
-
competitive
Phenylglyoxal
-
-
PMSF
-
20 mM, 59% residual activity
Polyvalent anions
-
S-nitro-N-acetyl-DL-penicillamine
-
-
tellurium
-
a decrease in specific activity is seen after combined treatment with zinc (515 mg/l) and tellurium (9.4 mg/l), but not with tellurium alone
additional information
-