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1.11.1.9: glutathione peroxidase

This is an abbreviated version!
For detailed information about glutathione peroxidase, go to the full flat file.

Word Map on EC 1.11.1.9

Reaction

2 glutathione +

H2O2
=
glutathione disulfide
+ 2 H2O

Synonyms

2-SeCD, 3,3'-telluro-bis(proapne-3,1-diyl)adamantane carboxylate, 6P229, ADA-Te-OH, ARMEP24, AtGPX1, ATGPX3, c-GPx4, Cellular glutathione peroxidase, cgd3_460, cGPx, Cuticular glycoprotein GP29, DI29, ebselen, EGLP, Epididymis-specific glutathione peroxidase-like protein, Extracellular glutathione peroxidase, G-6137, Gastrointestinal glutathione peroxidase, glutathione peroxidase 1, glutathione peroxidase 2, glutathione peroxidase 3, glutathione peroxidase 4, glutathione peroxidase Gpx2, glutathione peroxidase Gpx3, glutathione peroxidase-1, glutathione peroxidase-2, glutathione peroxidase-3, glutathione peroxidase-4, glutathione-dependent peroxidase I, glutathione:hydrogen-peroxide oxidoreductase, GP30, GPRP, GPX, Gpx-1, GPx-2, GPx-3, GPx-4, GPx-5, GPx-6, GPx-7, GPx-8, GPX1, Gpx2, GPX3, GPx4, GPX5, GSH peroxidase, GSH-Px, GSHPx, GSHPx-GI, intracellular GpX, m-GPx4, Major androgen-regulated protein, Major surface antigen GP29, n-GPx4, Nt-SubC08, Odorant-metabolizing protein RY2D1, Os02g0664000, OsGPX5, peroxidase, glutathione, PGdx, pGPx, PHGPX, phospholipid glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, nuclear form, phospholipid hydroperoxide Gpx, plasma glutathione peroxidase, prion protein Ure2, reduced glutathione peroxidase, Salt-associated protein, Se-GPx, Se-hGSTZ1-1, Se-scFv-B3, secreted GpX, SeGPx, selenium containing glutathione transferase zeta1-1, selenium-dependent glutathione peroxidase, selenium-glutathione peroxidase, seleno-dependent glutathione peroxidase 1, selenosubtilisin, snGPx, TcGPXI, TTHERM_00046090, TTHERM_00046110, TTHERM_01099010, Ure2

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.9 glutathione peroxidase

Expression

Expression on EC 1.11.1.9 - glutathione peroxidase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
a selenium deficient diet decreases glutathione reductase activity
-
adult male Swiss mice treated with 40 mg/ml methylmercury for 21 days show about 50% decrease in GPx activity in the brain
-
after Vibrio anguillarum and white spot syndrome virus challenge, glutathione peroxidase transcripts both in hemocytes and hepatopancreas increases about 3fold in the first 6 h and 3 h, respectively
enzyme activity in the serum of late-lactation cows is 2fold higher compared to dry cows and 4fold higher than in first-calving heifers and multiparous cows in early lactation
-
expression is increased after treatment with copper ions
feeding selenium-enriched Agaricus bisporus (0.001 mg Se/g feed) increases expression and activity of glutathione peroxidase-1 in rat colon by 1.65fold
feeding selenium-enriched Agaricus bisporus (0.001 mg Se/g feed)increases expression of glutathione peroxidase-2 in rat colon by 2.3fold
GPx-3 is induced by MG132 in HUVEC cells with an exponential increase in GPx-3 mRNA up to 120fold of control levels within 48 h. GPx-3 is still upregulated by a factor of 3-4 even after 72 and 96 h of proteasome inhibition. HAEC cells upregulate GPx-3 by more than 40fold in response to MG132. Proteasome inhibition clearly induces GPx-3 in HAoSMCs by a factor of 18
in liver, by 24 h, exposure to alow dose of Cd causes 13% loss of Gpx4a expression. At higher dose, Cd leads to 40% decrease in Gpx4a expression. Longer exposure periods cause about 20% loss of liver Gpx4a expression by low Cd dose
in Portunus trituberculatus challenged with the Hematodinium parasite, transcripts in hemocytes are initially suppressed at 3 h, and then induced significantly at all the other time points except for 96 h
in the brain, enzyme activity is significantly inhibited (51% after 28 days) during methylmercury exposure. In the case of co-exposure to methylmercury and selenium, inhibition of enzyme activity is less pronounced (25% at day 28)
-
no variation of enzyme expression is observed after a 1-day exposure to polychlorinated biphenyl 77
olfactory isoform Gpx4b mRNA expression is not extensively modulated by presence of cadmium ions. In liver, by 24 h, exposure to alow dose of Cd causes 18% loss of Gpx4b expression. At higher dose, Cd leads to 37% decrease in Gpx4b expression. Longer exposure periods cause about 22% loss of liver Gpx4b expression by low Cd dose, whereas at higher Cd exposures, a 33% loss in Gpx4b expression is observed
selenium treatment (0.01-0.03 mg/ml) significantly increases glutathione peroxidases activity in young barley seedlings
-
the enzyme (OsGPX5) is upregulated in response to hormone treatment. The OsGPX5 transcript is strongly induced by gibberellin or salicylic acid following a 3-h treatment and reaches maximum levels at 12 and 6 h, respectively. For abscisic acid treatment, OsGPX5 is activated and peaked within 3 h, approximately fourfold of the original level, and then declines to a normal level after 6 h. When rice seedlings are exposed to indole-3-acetic acid or 6-benzylaminopurine, a weak induction of the OsGPX5 transcript is observed within 1-h treatment and its expression sustaines at this level for 12 h. OsGPX5 mRNA level is weakly upregulated in response to heat
-
the enzyme expression level shows a 4 and a 2.6fold decrease after 3 and 7 days of exposure to polychlorinated biphenyl 77, respectively
the GPx gene contains a standard UGU codon for cysteine instead of a UGA opal codon for seleno-cysteine at the active site, and no selenoocysteine insertion sequence motif is identified within the 3'-untranslated region
the level of mRNA significantly increases 6 h after challenge with Vibrio harveyi, Staphyloccocus aureus or white spot syndrome virus
-
the seasonal gpx4 mRNA transcript is significantly lower in lizard brain during mating as compared with stasis. In testis the gpx4 mRNA transcript level is significantly higher in the mating phase
the transcript levels of antioxidant enzyme genes Gpx3, superoxide dismutase and catalase are induced after acute nitrite exposure. In the gill, the expression level of Gpx3 mRNA increases significantly from 6 to 12 h after nitrite exposure but returns to its original level after 24h
treatment with 7alpha,17beta-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol, i.e. ICI 182,780, increases expression during mating
treatment with human chorionic gonadotropin decreases expression in stasis
Vibrio challenge can significantly upregulate the mRNA expression of the enzyme, and the highest expression level (6.5fold) is detected at 24 h post infection with 6.5fold increase compared with that in the control group. Enzyme expression is significantly induced by 0.02 and 0.04 mg l-1 Cd (both 2.9fold after 24 h) and 0.01 and 0.02 mg l-1 Cu (2.7fold after 24 h and 1.6fold at 96 h, respectively). The mRNA expression is maximally induced (6.29fold) at 96 h post challenge with 0.05 mg l-1 benzo[a]pyrene
-