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2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
2 glutathione + H2O2
glutathione disulfide + 2 H2O
-
-
-
?
2 glutathione + phosphatidylcholine hydroperoxide
glutathione disulfide + ? + H2O
-
-
-
?
2 glutathione + tert-butyl hydroperoxide
glutathione disulfide + 2-methylpropan-2-ol + H2O
-
-
-
?
2 glutathione + tert-butyl hydroperoxide
glutathione disulfide + tert-butyl hydroxide + H2O
glutathione + (beta-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-gamma-palmitoyl)-L-alpha-phosphatidylcholine
?
-
-
-
-
?
glutathione + 1-palmitoyl-2-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-3-phosphatidylcholine
?
-
-
-
-
?
glutathione + 1-palmitoyl-2-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-L-3-phosphatidylcholine
?
-
-
-
-
?
glutathione + 3beta-hydroxycholest-5-ene-7alpha-hydroperoxide
cholest-5-ene-3beta,7alpha-diol + ?
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
glutathione + cardiolipin
?
glutathione + cholesterol hydroperoxide
?
-
-
-
-
?
glutathione + cholesterol hydroperoxides
?
glutathione + cumene hydroperoxide
?
glutathione + dilinoleoyl phosphatidylcholine hydroperoxide
?
glutathione + fatty acid hydroperoxides
?
-
-
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
glutathione + LDL hydroperoxides
?
-
-
-
-
?
glutathione + linoleic acid hydroperoxide
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
glutathione + phosphatidic acid hydroperoxide
?
-
-
-
-
?
glutathione + phosphatidylcholine hydroperoxide
?
glutathione + phosphatidylethanolamine hydroperoxide
?
-
-
-
-
?
glutathione + phosphatidylserine hydroperoxide
?
-
-
-
-
?
glutathione + phospholipid hydroperoxide
oxidized glutathione + phospholipid + H2O
-
-
-
-
r
glutathione + phospholipid hydroperoxides
?
glutathione + QKSPCCPKSP
?
-
-
-
?
glutathione + t-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
glutathione + tert-butyl-hydroperoxide
?
glutathione + tert-butylhydroperoxide
?
-
-
-
-
?
GSH + cumene hydroperoxide
GSSG + ?
GSH + H2O2
GSSG + ?
-
about 50% of the activity with cumene hydroperoxide
-
-
?
GSH + linoleic acid hydroperoxide
GSSG + ?
-
-
-
-
?
GSH + phosphatidylcholine dilinoleoyl hydroperoxide
GSSG + ?
-
-
-
-
?
GSH + tert-butyl hydroperoxide
GSSG + ?
KKSQCCQQKT + H2O2
KKSQ-L-cystinyl-QQKT + 2 H2O
-
-
-
?
KPPCCPPK + H2O2
KPP-L-cystinyl-PPK + 2 H2O
-
-
-
?
PKPPCCPPKP + H2O2
PKPP-L-cystinyl-PPKP + 2 H2O
-
-
-
?
PKSPCCPPKP + H2O2
PKSP-L-cystinyl-PPKP + 2 H2O
-
-
-
?
PKSPCCPPKS + H2O2
PKSP-L-cystinyl-PPKS + 2 H2O
-
-
-
?
PPCCPP + H2O2
PP-L-cystinyl-PP + 2 H2O
-
-
-
?
PPKPCCPPKP + H2O2
PPKP-L-cystinyl-PKP + 2 H2O
-
-
-
?
PPPPCCPPPP + H2O2
PPPP-L-cystinyl-PPPP + 2 H2O
-
-
-
?
QKPPCCPKSP + H2O2
QKPP-L-cystinyl-PKSP + 2 H2O
-
-
-
?
thioredoxin + 1-palmitoyl-2-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-L-3-phosphatidylcholine
?
-
-
-
-
?
additional information
?
-
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + tert-butyl hydroperoxide
glutathione disulfide + tert-butyl hydroxide + H2O
-
-
-
?
2 glutathione + tert-butyl hydroperoxide
glutathione disulfide + tert-butyl hydroxide + H2O
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
animal
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + cardiolipin
?
-
-
-
-
?
glutathione + cardiolipin
?
-
-
-
-
?
glutathione + cholesterol hydroperoxides
?
-
-
-
-
?
glutathione + cholesterol hydroperoxides
?
-
-
-
-
?
glutathione + cholesterol hydroperoxides
?
-
-
-
-
?
glutathione + cholesterol hydroperoxides
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
no activity
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + dilinoleoyl phosphatidylcholine hydroperoxide
?
-
-
-
-
?
glutathione + dilinoleoyl phosphatidylcholine hydroperoxide
?
-
and derivatives of dilinoyl phosphatidylcholine hydroperoxide
-
-
?
glutathione + H2O2
?
activity assay
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
no activity
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
protein follows a pingpong mechanism, which is similar to that of native cytosolic glutathione peroxidase, EC 1.11.1.9
-
?
glutathione + H2O2
?
-
no activity
-
-
?
glutathione + H2O2
?
-
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
activity assay
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
-
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
-
-
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
L-alpha-phosphatidylcholine hydroperoxide is a specific substrate of GPx4
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
-
-
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
-
-
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
-
-
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
-
-
-
-
?
glutathione + linoleic acid hydroperoxide
?
-
-
-
-
?
glutathione + linoleic acid hydroperoxide
?
-
-
-
-
?
glutathione + linoleic acid hydroperoxide
?
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
dithiothreitol, 2-mercaptoethanol, cysteine and homocysteine also serve as reducing agents
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
dithiothreitol and dithioerythritol are 3fold more active than glutathione, while 2-mercaptoethanol and L-cysteine show 50% and 20% of the activity with glutathione as reductants, respectively
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
ir
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
reduces hydroperoxides of phosphatidylcholine and cholesteryllinolate alone or associated to oxidized LDL and oxidized HDL
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
wide specificity for lipid hydroperoxides
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
the oxidized active site of the enzyme can also be reduced by mercaptoethanol
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
enzyme reduces amphiphilic peroxides, possibly at the water-lipid interface
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
role in cellular detoxification of a wide variety of lipid hydroperoxides in membranes and internalized lipoproteins
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + phosphatidylcholine hydroperoxide
?
activity assay
-
-
?
glutathione + phosphatidylcholine hydroperoxide
?
-
activity assay
-
-
?
glutathione + phosphatidylcholine hydroperoxide
?
-
activity assay
-
-
?
glutathione + phosphatidylcholine hydroperoxide
?
-
-
-
?
glutathione + phosphatidylcholine hydroperoxide
?
-
-
-
-
?
glutathione + phospholipid hydroperoxides
?
-
-
-
-
?
glutathione + phospholipid hydroperoxides
?
-
-
-
-
?
glutathione + phospholipid hydroperoxides
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
no activity
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl-hydroperoxide
?
-
-
-
?
glutathione + tert-butyl-hydroperoxide
?
-
activity assay
-
-
?
GSH + cumene hydroperoxide
GSSG + ?
-
-
-
-
?
GSH + cumene hydroperoxide
GSSG + ?
-
-
-
-
?
GSH + tert-butyl hydroperoxide
GSSG + ?
-
about 80% of the activity with cumene hydroperoxide
-
-
?
GSH + tert-butyl hydroperoxide
GSSG + ?
-
-
-
-
?
additional information
?
-
-
reduces hydroxyperoxide derivatives of phospholipids into alcohol derivatives
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
reduces hydroxyperoxide derivatives of phospholipids into alcohol derivatives
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
in addition to a structural role, PHGPx may also be involved in the non-enzymatic protection of sperm surface against detrimental effects caused by accumulation of modified lipids
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase are counterparts in the metabolism of hydroperoxy lipids
-
-
?
additional information
?
-
-
enzyme inhibits peroxidation of microsomes
-
-
?
additional information
?
-
-
the enzyme appears to be indispensable for structural integrity of spermatozoa and to codetermine sperm motility and viability
-
-
?
additional information
?
-
-
the enzyme plays an essential role in breast cancer cells in alleviating oxidative stress generated from polyunsaturated fatty acid metabolism
-
-
?
additional information
?
-
-
GPx4 can react with H2O2 and a wide range of lipid hydroperoxides including oxidized phospholipids and cholesterol hydroperoxides
-
-
?
additional information
?
-
different isomers of the hydroperoxide hydroperoxy-octadecadienoic acid (HpODE) are formed depending on whether linoleic acid is subjected to enzymatic, free radical, or non-radical attack
-
-
-
additional information
?
-
-
tyrosine phosphorylation of the enzyme may represent an important event in the signaling cascade associated with capacitation that may impact the regulation of hyperactivation of sperm motility and/or mitochondrial function
-
-
?
additional information
?
-
-
PHGPx-/- mice are embryonically lethal at gestation day 7.5. PHGPx+/- mice cells show decreased life span after exposure to irradiation and increased susceptibility to oxidative and genotoxic stress
-
-
?
additional information
?
-
-
preferred substrates are found to be hydroperoxide groups of phosphatidylcholine and on cumene and t-butyl hydroperoxides
-
-
?
additional information
?
-
-
reduces lipid hydroperoxides in biomembranes
-
-
?
additional information
?
-
-
reduces hydroxyperoxide derivatives of phospholipids into alcohol derivatives
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
mitochondrial enzyme inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis
-
-
?
additional information
?
-
-
controlled by gonadotropin
-
-
?
additional information
?
-
total GPx activity is determined in a photometric NADPH-coupled assay using tert-BHP as the substrate. The decrease of NADPH absorbance is monitored at 340 nm
-
-
-
additional information
?
-
total GPx activity is determined in a photometric NADPH-coupled assay using tert-BHP as the substrate. The decrease of NADPH absorbance is monitored at 340 nm
-
-
-
additional information
?
-
-
specifically detoxifies phospholipid peroxide
-
-
?
additional information
?
-
-
the enzyme shows phospholipid hydroperoxide glutathione peroxidase activity and thioredoxin peroxidase activity. Thioredoxin peroxidase activity is higher than phospholipid hydroperoxidase activity in terms of efficiency and substrate affinities. No activity with glutathione + H2O2
-
-
?
additional information
?
-
-
reduces hydroxyperoxide derivatives of phospholipids into alcohol derivatives
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
PhGPx prevents NF-kappaB activation, oxLDL-induced proliferation and linoleic acid-induced apoptosis
-
-
?
additional information
?
-
PHGPx is an antioxidant enzyme that can reduce peroxidized phospholipids produced in cell membranes
-
-
?
additional information
?
-
-
the enzyme is not enzymatically active but may be able to interact with modified phospholipids on the membrane, thereby masking or removing potentially damaging lipids from the surface of the parasitpoids eggs
-
-
?