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1.11.1.12: phospholipid-hydroperoxide glutathione peroxidase

This is an abbreviated version!
For detailed information about phospholipid-hydroperoxide glutathione peroxidase, go to the full flat file.

Word Map on EC 1.11.1.12

Reaction

2 glutathione +

a hydroperoxy-fatty-acyl-[lipid]
=
glutathione disulfide
+
a hydroxy-fatty-acyl-[lipid]
+
H2O

Synonyms

AC-PHGPx, Bi-PHGPx, class 4 GPx, CsGPx1, CsGPx2, CsGPx3, CsGPx4, DMPHGPx, glutathione peroxidase 4, glutathione peroxidase-4, glutathione-dependent phospholipid peroxidase, GPX, GPx-4, GPX3, GPx4, GPx41, GPx4A, GPx4B, GPXhs2, GPXle1, hydroperoxide glutathione peroxidase, Hyr1, Hyr1/YIR037W, McPHGPx, More, non-selenocysteine PHGPx, NPGPx, nPHGPx, OsPHGPx, peroxidation-inhibiting protein, peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing), PHGPX, phospholipid glutathione peroxidase, phospholipid hydroperoxidase, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase A, phospholipid hydroperoxide glutathione peroxidase B, phospholipid hydroperoxide glutathione peroxidase-4, phospholipid-hydroperoxide glutathione peroxidase, selenium-dependent glutathione peroxidase type-4, seleno GPx, selenoperoxidase, selenoprotein P, sperm nucleus-specific glutathione peroxidase, TTHERM_00661720, type-4 glutathione peroxidase, VcPHGPx

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase

Substrates Products

Substrates Products on EC 1.11.1.12 - phospholipid-hydroperoxide glutathione peroxidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
show the reaction diagram
2 glutathione + H2O2
glutathione disulfide + 2 H2O
show the reaction diagram
-
-
-
?
2 glutathione + phosphatidylcholine hydroperoxide
glutathione disulfide + ? + H2O
show the reaction diagram
-
-
-
?
2 glutathione + tert-butyl hydroperoxide
glutathione disulfide + 2-methylpropan-2-ol + H2O
show the reaction diagram
-
-
-
?
2 glutathione + tert-butyl hydroperoxide
glutathione disulfide + tert-butyl hydroxide + H2O
show the reaction diagram
glutathione + (beta-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-gamma-palmitoyl)-L-alpha-phosphatidylcholine
?
show the reaction diagram
-
-
-
-
?
glutathione + 1-palmitoyl-2-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-3-phosphatidylcholine
?
show the reaction diagram
-
-
-
-
?
glutathione + 1-palmitoyl-2-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-L-3-phosphatidylcholine
?
show the reaction diagram
-
-
-
-
?
glutathione + 3beta-hydroxycholest-5-ene-7alpha-hydroperoxide
cholest-5-ene-3beta,7alpha-diol + ?
show the reaction diagram
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
show the reaction diagram
glutathione + cardiolipin
?
show the reaction diagram
glutathione + cholesterol hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + cholesterol hydroperoxides
?
show the reaction diagram
glutathione + cumene hydroperoxide
?
show the reaction diagram
glutathione + dilinoleoyl phosphatidylcholine hydroperoxide
?
show the reaction diagram
glutathione + fatty acid hydroperoxides
?
show the reaction diagram
-
-
-
-
?
glutathione + H2O2
?
show the reaction diagram
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
show the reaction diagram
glutathione + LDL hydroperoxides
?
show the reaction diagram
-
-
-
-
?
glutathione + linoleic acid hydroperoxide
?
show the reaction diagram
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
show the reaction diagram
glutathione + phosphatidic acid hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + phosphatidylcholine hydroperoxide
?
show the reaction diagram
glutathione + phosphatidylethanolamine hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + phosphatidylserine hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + phospholipid hydroperoxide
oxidized glutathione + phospholipid + H2O
show the reaction diagram
-
-
-
-
r
glutathione + phospholipid hydroperoxides
?
show the reaction diagram
glutathione + QKSPCCPKSP
?
show the reaction diagram
-
-
-
?
glutathione + t-butyl hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
show the reaction diagram
glutathione + tert-butyl-hydroperoxide
?
show the reaction diagram
glutathione + tert-butylhydroperoxide
?
show the reaction diagram
-
-
-
-
?
GSH + cumene hydroperoxide
GSSG + ?
show the reaction diagram
GSH + H2O2
GSSG + ?
show the reaction diagram
-
about 50% of the activity with cumene hydroperoxide
-
-
?
GSH + linoleic acid hydroperoxide
GSSG + ?
show the reaction diagram
-
-
-
-
?
GSH + phosphatidylcholine dilinoleoyl hydroperoxide
GSSG + ?
show the reaction diagram
-
-
-
-
?
GSH + tert-butyl hydroperoxide
GSSG + ?
show the reaction diagram
KKSQCCQQKT + H2O2
KKSQ-L-cystinyl-QQKT + 2 H2O
show the reaction diagram
-
-
-
?
KPPCCPPK + H2O2
KPP-L-cystinyl-PPK + 2 H2O
show the reaction diagram
-
-
-
?
PKPPCCPPKP + H2O2
PKPP-L-cystinyl-PPKP + 2 H2O
show the reaction diagram
-
-
-
?
PKSPCCPPKP + H2O2
PKSP-L-cystinyl-PPKP + 2 H2O
show the reaction diagram
-
-
-
?
PKSPCCPPKS + H2O2
PKSP-L-cystinyl-PPKS + 2 H2O
show the reaction diagram
-
-
-
?
PPCCPP + H2O2
PP-L-cystinyl-PP + 2 H2O
show the reaction diagram
-
-
-
?
PPKPCCPPKP + H2O2
PPKP-L-cystinyl-PKP + 2 H2O
show the reaction diagram
-
-
-
?
PPPPCCPPPP + H2O2
PPPP-L-cystinyl-PPPP + 2 H2O
show the reaction diagram
-
-
-
?
QKPPCCPKSP + H2O2
QKPP-L-cystinyl-PKSP + 2 H2O
show the reaction diagram
-
-
-
?
thioredoxin + 1-palmitoyl-2-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-L-3-phosphatidylcholine
?
show the reaction diagram
-
-
-
-
?
additional information
?
-