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1.11.1.12: phospholipid-hydroperoxide glutathione peroxidase

This is an abbreviated version!
For detailed information about phospholipid-hydroperoxide glutathione peroxidase, go to the full flat file.

Word Map on EC 1.11.1.12

Reaction

2 glutathione +

a hydroperoxy-fatty-acyl-[lipid]
=
glutathione disulfide
 +
a hydroxy-fatty-acyl-[lipid]
 +
H2O

Synonyms

AC-PHGPx, Bi-PHGPx, class 4 GPx, CsGPx1, CsGPx2, CsGPx3, CsGPx4, DMPHGPx, glutathione peroxidase 4, glutathione peroxidase-4, glutathione-dependent phospholipid peroxidase, GPX, GPx-4, GPX3, GPx4, GPx41, GPx4A, GPx4B, GPXhs2, GPXle1, hydroperoxide glutathione peroxidase, Hyr1, Hyr1/YIR037W, McPHGPx, More, non-selenocysteine PHGPx, NPGPx, nPHGPx, OsPHGPx, peroxidation-inhibiting protein, peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing), PHGPX, phospholipid glutathione peroxidase, phospholipid hydroperoxidase, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase A, phospholipid hydroperoxide glutathione peroxidase B, phospholipid hydroperoxide glutathione peroxidase-4, phospholipid-hydroperoxide glutathione peroxidase, selenium-dependent glutathione peroxidase type-4, seleno GPx, selenoperoxidase, selenoprotein P, sperm nucleus-specific glutathione peroxidase, TTHERM_00661720, type-4 glutathione peroxidase, VcPHGPx

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase

Specific Activity

Specific Activity on EC 1.11.1.12 - phospholipid-hydroperoxide glutathione peroxidase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0038
-
crude platelet homogenate
0.0048
-
cytosolic fraction
0.006
-
mitochondrial fraction
0.009
-
-
0.0096
-
membrane fraction
0.04
-
low-PHGPx group
0.051
-
enzyme from tissue lysate, using L-alpha-phosphatidylcholine hydroperoxide as peroxide substrate, at 37°C
0.0539
-
low-PHGPx, Chianina
0.056
-
low-PHGPx, Marchigiana
0.0746
-
low-PHGPx, Romagnola
0.13
-
high-PHGPx group
0.2242
-
high-PHGPx, Chianina
0.2447
-
high-PHGPx, Romagnola
0.2453
-
high-PHGPx, Marchigiana
0.3
in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM KKSQCCQQKT as substrate
0.4
in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM KPPCCPPK as substrate
0.9
-
substrate tert-butyl hydroperoxide
107
-
purified enzyme
109900
-
purified enzyme from cytosol
13.6
in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM PKSPCCPPKP as substrate
14
substrate tert-butyl hydroperoxide, pH 7.4, 37°C
146300
-
purified enzyme from mitochondria
160
-
purified enzyme, substrate linoleic acid hydroperoxide
160.2
in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM PPCCPP as substrate
190
-
purified enzyme, substrate cumene hydroperoxide
195.1
-
purified enzyme
2.03
-
addition of Triton X-100 and deoxycholate
2.2
-
substrate phosphatidylcholine
21.5
-
enzyme after 422fold purification, using L-alpha-phosphatidylcholine hydroperoxide as peroxide substrate, at 37°C
210
-
purified enzyme, substrate H2O2
25
substrate phosphatidylcholine hydroperoxide, pH 7.4, 37°C
25.2
in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM PPKPCCPPKP as substrate
28.3
in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM PKPPCCPPKP as substrate
3.8
-
substrate cumene hydroperoxide
30.6
pH 7.4, 37°C
310.1
-
purified enzyme
336
-
purified enzyme, substrate (beta-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-gamma-palmitoyl)-L-alpha-phosphatidylcholine
36
in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM QKSPCCPKSP as substrate
37.5
in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM QKPPCCPKSP as substrate
42
in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM PKSPCCPPKS as substrate
56
substrate H2O2, pH 7.4, 37°C
69
in 0.1 M potassium phosphate, pH 7.8 with 1 mM EDTA, using 0.1 mM PPPPCCPPPP as substrate
7
-
purified enzyme
90
-
partially purified enzyme
additional information