1.1.99.37: methanol dehydrogenase (nicotinoprotein)

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For detailed information about methanol dehydrogenase (nicotinoprotein), go to the full flat file.

Reaction

Synonyms

MDH, MDO, methanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase, NAD-dependent methanol dehydrogenase, NDMA-dependent methanol dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.99 With unknown physiological acceptors

                1.1.99.37 methanol dehydrogenase (nicotinoprotein)

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Results	in table
1	Activating Compound
119	AA Sequence
3	Cloned(Commentary)
6	Cofactor
2	Crystallization (Commentary)
3	Expression
3	General Information
4	Inhibitors
1	KM Value [mM]
2	Localization
7	Metals/Ions
5	Molecular Weight [Da]
9	Organism
1	Pathway
1	pI Value
8	Protein Variants
2	Purification (Commentary)
4	Reaction
7	Reference
4	Specific Activity [micromol/min/mg]
2	Storage Stability
11	Substrates and Products (Substrate)
6	Subunits
11	Synonyms
1	Systematic Name

Activating Compound

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Activating Compound on EC 1.1.99.37 - methanol dehydrogenase (nicotinoprotein)

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

additional information

Bacillus methanolicus

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the low coenzyme NAD-dependent activity of MDH with C1-C4 primary alcohols is strongly stimulated by Bacillus methanolicus protein ACT, in presence of NAD(H) cofactor and Mg2+-ions. In the deduced ACT amino acid sequence, the highly conserved amino acid sequence motif typical of Nudix hydrolase proteins is present. MDH activation by ACT involves hydrolytic removal of the nicotinamide mononucleotide NMN(H) moiety of the NAD(H) cofactor of MDH, changing its Ping-Pong type of reaction mechanism into a ternary complex reaction mechanism

656074

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