1.1.99.24: hydroxyacid-oxoacid transhydrogenase
This is an abbreviated version!
For detailed information about hydroxyacid-oxoacid transhydrogenase, go to the full flat file.
Word Map on EC 1.1.99.24
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1.1.99.24
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gamma-hydroxybutyrate
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semialdehyde
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2-hydroxyglutarate
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iron-containing
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acidurias
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oncometabolite
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2-ketoglutarate
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diagnostics
- 1.1.99.24
- gamma-hydroxybutyrate
- semialdehyde
- 2-hydroxyglutarate
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iron-containing
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acidurias
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oncometabolite
- 2-ketoglutarate
- diagnostics
Reaction
Synonyms
ADHFE1, alcohol dehydrogenase iron containing 1, HOT, hydroxyacid-oxoacid transhydrogenase, iron-dependent alcohol dehydrogenase ADHFe1, transhydrogenase, hydroxy acid-oxo acid
ECTree
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Substrates Products
Substrates Products on EC 1.1.99.24 - hydroxyacid-oxoacid transhydrogenase
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REACTION DIAGRAM
4-hydroxybutanoic acid + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
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additional information
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D-2-hydroxyglutaric aciduria is not associated to the enzyme activity
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?
acetoacetate + (R)-2-hydroxyglutarate
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?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
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?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
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?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
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?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
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?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
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?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
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?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
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?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
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?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
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?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
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?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
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?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
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?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
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?
succinic semialdehyde + D-2-hydroxyglutarate
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r
3-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
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radiolabeled substrate 3-hydroxybutyrate, stereospecific reaction
radiolabeled product D-2-hydroxyglutarate
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r
D-2-hydroxyglutarate + succinate semialdehyde
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?
4-hydroxybutyrate + 2-oxoglutarate
D-2-hydroxyglutarate + succinate semialdehyde
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?
succinic semialdehyde + 2-hydroxyglutarate
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r
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + 2-hydroxyglutarate
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hydrogen attached to hydroxyl-bearing C of 4-hydroxybutyrate is transferred to ketone-bearing C of 2-oxoglutarate, oxoacid not NAD+ or NADP+ acts as hydrogen acceptor
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r
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + 2-hydroxyglutarate
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hydrogen attached to hydroxyl-bearing C of 4-hydroxybutyrate is transferred to ketone-bearing C of 2-oxoglutarate, oxoacid not NAD+ or NADP+ acts as hydrogen acceptor
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r
succinic semialdehyde + D-2-hydroxyglutarate
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?
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
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recombinant enzyme in HEK-293 cells
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?
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
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r
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
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stereospecific reaction, no activity with L-2-hydroxyglutarate
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r
2-oxoglutarate + 4-hydroxybutyrate
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?
D-2-hydroxyglutarate + succinic semialdehyde
2-oxoglutarate + 4-hydroxybutyrate
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D-2-hydroxyglutarate + succinic semialdehyde
2-oxoglutarate + 4-hydroxybutyrate
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acetoacetate + 2-oxoglutarate
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L-3-hydroxybutyrate + 2-oxoglutarate
acetoacetate + 2-oxoglutarate
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oxidized at 33% the rate of 4-hydroxybutyrate
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L-3-hydroxybutyrate + 2-oxoglutarate
acetoacetate + 2-oxoglutarate
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oxidized at 33% the rate of 4-hydroxybutyrate
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acetoacetate + 4-hydroxybutyrate
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L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
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oxo-acids that can act as hydrogen acceptors are 2-oxoadipate, 24% as effective as 2-oxoglutarate and oxaloacetate, 19% as effective as 2-oxoglutarate, D-3-hydroxybutyrate, DL-2-hydroxybutyrate, D/L-malate, D/L-lactate, acetoacetate, 3-oxobutyrate, 3-oxoadipate do not act as hydrogen acceptors, poor acceptors are pyruvate and 2-oxobutyrate
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L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
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62.5% of activity with D-2-hydroxyglutarate
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L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
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oxo-acids that can act as hydrogen acceptors are 2-oxoadipate, 24% as effective as 2-oxoglutarate and oxaloacetate, 19% as effective as 2-oxoglutarate, D-3-hydroxybutyrate, DL-2-hydroxybutyrate, D/L-malate, D/L-lactate, acetoacetate, 3-oxobutyrate, 3-oxoadipate do not act as hydrogen acceptors, poor acceptors are pyruvate and 2-oxobutyrate
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?
L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
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62.5% of activity with D-2-hydroxyglutarate
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?