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1.1.99.24: hydroxyacid-oxoacid transhydrogenase

This is an abbreviated version!
For detailed information about hydroxyacid-oxoacid transhydrogenase, go to the full flat file.

Word Map on EC 1.1.99.24

Reaction

(S)-3-hydroxybutanoate
+
2-oxoglutarate
=
acetoacetate
+
(R)-2-hydroxyglutarate

Synonyms

ADHFE1, alcohol dehydrogenase iron containing 1, HOT, hydroxyacid-oxoacid transhydrogenase, iron-dependent alcohol dehydrogenase ADHFe1, transhydrogenase, hydroxy acid-oxo acid

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.99 With unknown physiological acceptors
                1.1.99.24 hydroxyacid-oxoacid transhydrogenase

Substrates Products

Substrates Products on EC 1.1.99.24 - hydroxyacid-oxoacid transhydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
show the reaction diagram
3-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
show the reaction diagram
4-hydroxybutanoic acid + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
show the reaction diagram
-
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
D-2-hydroxyglutarate + succinate semialdehyde
show the reaction diagram
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + 2-hydroxyglutarate
show the reaction diagram
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
show the reaction diagram
D-2-hydroxybutyrate + 2-oxoglutarate
?
show the reaction diagram
-
-
-
-
r
D-2-hydroxyglutarate + succinic semialdehyde
2-oxoglutarate + 4-hydroxybutyrate
show the reaction diagram
L-3-hydroxybutyrate + 2-oxoglutarate
acetoacetate + 2-oxoglutarate
show the reaction diagram
L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
show the reaction diagram
additional information
?
-
-
D-2-hydroxyglutaric aciduria is not associated to the enzyme activity
-
-
?