1.1.99.21: D-sorbitol dehydrogenase (acceptor)
This is an abbreviated version!
For detailed information about D-sorbitol dehydrogenase (acceptor), go to the full flat file.
Reaction
Synonyms
D-sorbitol dehydrogenase, FAD-SLDH, GoSLDH, mSLDH, PQQ-dependent D-sorbitol dehydrogenase, SDH, SLDH, sldhAB, sorbitol dehydrogenase
ECTree
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General Information
General Information on EC 1.1.99.21 - D-sorbitol dehydrogenase (acceptor)
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evolution
malfunction
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mutation of His302 results in the denaturation of protein structure and loss of stability
metabolism
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membrane-bound D-sorbitol dehydrogenase is involved in the biotransformation of D-sorbitol to L-sorbose
additional information
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GoSLDH sequencing, structure analyses, and biochemical studies, suggest that it belongs to the NADP+-dependent polyol specific long-chain sorbitol dehydrogenase family. GoSLDH possesses the active site residues of Asp190, Val228, Lys294, and Asp299 and the conserved catalytic motif (KXXXXHXXH) for polyol-specific long-chain dehydrogenase
evolution
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GoSLDH sequencing, structure analyses, and biochemical studies, suggest that it belongs to the NADP+-dependent polyol specific long-chain sorbitol dehydrogenase family. GoSLDH possesses the active site residues of Asp190, Val228, Lys294, and Asp299 and the conserved catalytic motif (KXXXXHXXH) for polyol-specific long-chain dehydrogenase
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sequence alignment-based homology modeling using the structure of NAD-bound sorbitol dehydrogenase, EC 1.1.1.14, with UniProt ID Q9KWR5 as template
additional information
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structure comparisons and molecular docking, overview
additional information
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structure comparisons and molecular docking, overview
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