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1.1.3.15: (S)-2-hydroxy-acid oxidase

This is an abbreviated version!
For detailed information about (S)-2-hydroxy-acid oxidase, go to the full flat file.

Word Map on EC 1.1.3.15

Reaction

an (S)-2-hydroxy carboxylate
+
O2
=
a 2-oxo carboxylate
+
H2O2

Synonyms

(L)-2-HAOX, (S)-2-hydroxy-acid oxidase, peroxisomal, 2-hydroxy acid oxidase, CSUB_C1080, EC 1.1.3.1, GLO, Glo1, GLO3, Glo4, glycolate oxidase, GO, GO1, GOX, GOX1, GOX2, HAO1, Hao2, HAOX, HAOX1, HAOX2, HAOX3, hydroxy-acid oxidase A, hydroxy-acid oxidase B, hydroxyacid oxidase 1, hydroxyacid oxidase A, L-2-hydroxy acid oxidase, L-2-hydroxyacid oxidase A, L-alpha-hydroxy acid oxidase, L-amino acid oxidase, L-LAC-OX, L-lactate monooxygenase, L-lactate oxidase, L-LOx, lactate oxidase, LCHAO, LctO, lHAOX1, lHAOX2, long chain hydroxy acid oxidase, long chain l-2-hydroxy acid oxidase, long chain L-2-hydroxy acid oxidase 2, long-chain 2-hydroxy acid oxidase, long-chain L-alpha-hydroxy acid oxidase, LOX, More, NbS00005125g0015, NbS00060838g0004, Nbv5tr6245008, Os03g0786100, Os04g0623500, Os07g0616500, oxidase, L-2-hydroxy acid, RCOM_0631490, RCOM_0684800

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.3 With oxygen as acceptor
                1.1.3.15 (S)-2-hydroxy-acid oxidase

KI Value

KI Value on EC 1.1.3.15 - (S)-2-hydroxy-acid oxidase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
9.04
(R)-lactate
-
at pH 7.0
0.078
2,6-dichlorophenolindophenol
-
-
0.317
2-hydroxy butyrate
-
at pH 7.0
37 - 494
acetate
3.6
Butyrate
-
non-competitive, glycolate oxidation
3
caproate
-
-
280
chloride
pH 7.0, 25°C
0.00169
Cibacron blue 3GA
-
at pH 6.0
0.27 - 0.77
diethyldithiocarbamate
0.13
dihydrolipoate
-
-
0.317 - 46
glycolate
12
glyoxylate
-
-
0.092
Heptanoate
-
non-competitive, glycolate oxidation
0.3
hexanoate
-
non-competitive, glycolate oxidation
0.52 - 0.88
KCN
23
L-leucine
-
-
0.3 - 92
L-Mandelate
8.2 - 9.2
malonate
0.03
NAD+
-
pH 7.4, 25°C
0.44 - 23
oxalate
171
oxamate
-
-
2.5
Phenyllactate
-
competitive
9.5 - 126
propionate
15.9 - 18.3
pyruvate
14
succinate
-
competitive, glycolate oxidation
1 - 1.9
trans-cinnamate
1.2 - 1.3
valerate
additional information
additional information
-
straight-chain monocarboxylic acids are non-competitive inhibitors with either glycolate or glyoxylate as substrates, dicarboxylic acids are competitive inhibitors with glycolate as substrate, but non-competitive inhibitors for glyoxylate as substrate
-