1.1.1.B57: 1-tetralone reductase [NADPH]

This is an abbreviated version, for detailed information about 1-tetralone reductase [NADPH], go to the full flat file.

Reaction

1-tetralone
+
NADPH
+
H+
=
1-tetralol
+
NADP+

Synonyms

ADHII, PAE2687, PyAeADHII

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B57 1-tetralone reductase [NADPH]

Crystallization

Crystallization on EC 1.1.1.B57 - 1-tetralone reductase [NADPH]

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Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
crystal structure of both wild-type and cobalt-substituted enzyme at 1.75 A and 2.20 A resolution, respectively. One metal ion per monomer is present only at the structural site. The co-crystal structure of the NADPH-bound form of the enzyme at 2.35 A resolution shows close structural conservation with horse ADH, despite the lack of a catalytic Zn2+. Modeling of 1-tetralone into the NADPH-bound structure suggests an arginine as a possible catalytic residue
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