1.1.1.B52: 3-quinuclidinone reductase (NADH)

This is an abbreviated version, for detailed information about 3-quinuclidinone reductase (NADH), go to the full flat file.

Reaction

(R)-3-quinuclidinol
+
NAD+
=
3-quinuclidinone
+
NADH
+
H+

Synonyms

alcohol dehydrogenase, ArQR, AtQR, BacC, QNR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B52 3-quinuclidinone reductase (NADH)

Reference

Reference on EC 1.1.1.B52 - 3-quinuclidinone reductase (NADH)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hou, F.; Miyakawa, T.; Takeshita, D.; Kataoka, M.; Uzura, A.; Nagata, K.; Shimizu, S.; Tanokura, M.
Expression, purification, crystallization and X-ray analysis of 3-quinuclidinone reductase from Agrobacterium tumefaciens
Acta Crystallogr. Sect. F
68
1237-1239
2012
Agrobacterium tumefaciens (G1K3P5)
Manually annotated by BRENDA team
Isotani, K.; Kurokawa, J.; Suzuki, F.; Nomoto, S.; Negishi, T.; Matsuda, M.; Itoh, N.
Gene cloning and characterization of two NADH-dependent 3-quinuclidinone reductases from Microbacterium luteolum JCM 9174
Appl. Environ. Microbiol.
79
1378-1384
2012
Microbacterium luteolum (L8B2H6), Microbacterium luteolum JCM 9174 (L8B2H6)
Manually annotated by BRENDA team
Hou, F.; Miyakawa, T.; Kataoka, M.; Takeshita, D.; Kumashiro, S.; Uzura, A.; Urano, N.; Nagata, K.; Shimizu, S.; Tanokura, M.
Structural basis for high substrate-binding affinity and enantioselectivity of 3-quinuclidinone reductase AtQR
Biochem. Biophys. Res. Commun.
446
911-915
2014
Agrobacterium tumefaciens (G1K3P5)
Manually annotated by BRENDA team
Isotani, K.; Kurokawa, J.; Itoh, N.
Production of (R)-3-quinuclidinol by E. coli biocatalysts possessing NADH-dependent 3-quinuclidinone reductase (QNR or bacC) from Microbacterium luteolum and Leifsonia alcohol dehydrogenase (LSADH)
Int. J. Mol. Sci.
13
13542-13553
2012
Microbacterium luteolum (L8B2H6), Microbacterium luteolum JCM 9174 (L8B2H6)
Manually annotated by BRENDA team
Zhang, W.X.; Xu, G.C.; Huang, L.; Pan, J.; Yu, H.L.; Xu, J.H.
Highly efficient synthesis of (R)-3-quinuclidinol in a space-time yield of 916 g L(-1) d(-1) using a new bacterial reductase ArQR
Org. Lett.
15
4917-4919
2013
Agrobacterium tumefaciens (B9JM87), Agrobacterium tumefaciens ECU2556 (B9JM87)
Manually annotated by BRENDA team
Spickermann, D.; Hausmann, S.; Degering, C.; Schwaneberg, U.; Leggewie, C.
Engineering of highly selective variants of Parvibaculum lavamentivorans alcohol dehydrogenase
ChemBioChem
15
2050-2052
2014
Parvibaculum lavamentivorans
Manually annotated by BRENDA team