1.1.1.B51: 3-quinuclidinone reductase (NADPH)

This is an abbreviated version, for detailed information about 3-quinuclidinone reductase (NADPH), go to the full flat file.

Reaction

(R)-3-quinuclidinol
+
NADP+
=
3-quinuclidinone
+
NADPH
+
H+

Synonyms

RrQR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B51 3-quinuclidinone reductase (NADPH)

Engineering

Engineering on EC 1.1.1.B51 - 3-quinuclidinone reductase (NADPH)

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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
F212A
-
complete loss of activity
F212L
-
complete loss of activity
I167A
-
complete loss of activity
I167V
-
relative activity for 3-qinuclidinone is 24.5% compared to wild-type enzyme
K185A
-
complete loss of activity
N173A
-
relative activity for 3-qinuclidinone is 97.8% compared to wild-type enzyme
Q178A
-
relative activity for 3-qinuclidinone is 164.5% compared to wild-type enzyme
S166A
-
complete loss of activity
S168A
-
relative activity for 3-qinuclidinone is 115.7% compared to wild-type enzyme
Y181A
-
complete loss of activity
Y181F
-
complete loss of activity