1.1.1.B51: 3-quinuclidinone reductase (NADPH)

This is an abbreviated version, for detailed information about 3-quinuclidinone reductase (NADPH), go to the full flat file.

Reaction

(R)-3-quinuclidinol
+
NADP+
=
3-quinuclidinone
+
NADPH
+
H+

Synonyms

RrQR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B51 3-quinuclidinone reductase (NADPH)

Cloned

Cloned on EC 1.1.1.B51 - 3-quinuclidinone reductase (NADPH)

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
an expression vector, pWKLQ, which contains the full length 3-quinuclidinone reductase gene is constructed. Using Escherichia coli cells coexpressing the 3-quinuclidinone reductase and glucose dehydrogenase (cofactor regeneration enzyme) genes, 618 mM 3-quinuclidinone is almost stiochiometrically converted to (R)-3-quinuclidinol with an >99.9% enantiomeric excess within 21 h of reaction
-
expressed in Escherichia coli
-