1.1.1.B47: succinate semialdehyde reductase (NADPH)

This is an abbreviated version, for detailed information about succinate semialdehyde reductase (NADPH), go to the full flat file.

Reaction

4-hydroxybutanoate
+
NADP+
=
succinate semialdehyde
+
NADPH
+
H+

Synonyms

At3g25530, AtGLYR1, Msed_1424, SSA, succinate semialdehyde reductase, succinic semialdehyde reductase, succinic semialdehyde reductase (NADPH)

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B47 succinate semialdehyde reductase (NADPH)

General Information

General Information on EC 1.1.1.B47 - succinate semialdehyde reductase (NADPH)

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
the primary sequence of cytosolic AtGLYR1 reveals several sequence elements that are consistent with the beta-HAD (beta-hydroxyacid dehydrogenase) protein family, sequence alignment of AtGLYR1 and beta-HAD family members, overview
metabolism
additional information
identification of catalytically important amino acid residues for enzymatic reduction of glyoxylate in plants by bifunctional enzyme glyoxylate/succinic semialdehyde reductase 1, that converts both glyoxylate and succinic semialdehyde into their corresponding hydroxyacid equivalents. Residue Lys170 is essential for catalysis, Phe231, Asp239, Ser121 and Thr95 are more important in substrate binding than in catalysis, and Asn174 is more important in catalysis