1.1.1.B40: 11beta-hydroxysteroid dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about 11beta-hydroxysteroid dehydrogenase (NAD+), go to the full flat file.

Reaction

an 11beta-hydroxysteroid
+
NAD+
=
an 11-oxosteroid
+
NADH
+
H+

Synonyms

11 beta-hydroxysteroid dehydrogenase, 11 beta-hydroxysteroid dehydrogenase type 2, 11-beta-HSD2, 11beta hydroxysteroid dehydrogenase type 2, 11beta-HSD, 11beta-HSD 2, 11beta-HSD type 2, 11beta-HSD1, 11beta-HSD2, 11beta-HSD2 (oxidase) NAD+, 11beta-hydroxysteroid dehydrogenase 2, 11beta-hydroxysteroid dehydrogenase isoforms 2, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type-2, 11beta-hydroxysteroid dehydrogenases type 2, 11beta-OHSD, 11betaHSD2, 7-alpha-HCD, 7-alpha-hydroxycholesterol dehydrogenase, corticosteroid 11-beta-dehydrogenase isozyme 1, HSD 2, isozyme 11beta-HSD2, More, NAD(+)-dependent 11beta-dehydrogenase, NAD+-dependent 11beta-hydroxysteroid dehydrogenase 2, type 2 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B40 11beta-hydroxysteroid dehydrogenase (NAD+)

Substrates Products

Substrates Products on EC 1.1.1.B40 - 11beta-hydroxysteroid dehydrogenase (NAD+)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
show the reaction diagram
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
show the reaction diagram
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
show the reaction diagram
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
show the reaction diagram
11beta-hydroxytestosterone + NAD+
11-oxotestosterone + NADH
show the reaction diagram
-
-
-
?
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
show the reaction diagram
1beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
show the reaction diagram
-
i.e. corticosterone, no reductase activity in aldosterone-sensitive collecting duct
-
-
ir
7-oxocholesterol + NADPH
7alpha-hydroxycholesterol + NADP+
show the reaction diagram
isozyme 11beta-HSD1, stereospecific reaction
-
-
?
7-oxocholesterol + NADPH
7beta-hydroxycholesterol + NADP+
show the reaction diagram
corticosterone + NAD+
11-dehydrocorticosterone + NADH
show the reaction diagram
cortisol + NAD+
cortisone + NADH
show the reaction diagram
cortisol + NAD+
cortisone + NADH + H+
show the reaction diagram
cortisone + NADPH
cortisol + NADP+
show the reaction diagram
dexamethasone + NAD+
11-dehydromethasone + NADH
show the reaction diagram
additional information
?
-