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11-dehydrocorticosterone + NADPH
corticosterone + NADP+
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
11beta-hydroxytestosterone + NAD+
11-oxotestosterone + NADH
-
-
-
?
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
1beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone, no reductase activity in aldosterone-sensitive collecting duct
-
-
ir
corticosterone + beta-NAD+
11-dehydrocorticosterone + beta-NADH
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
cortisol + beta-NAD+
cortisone + beta-NADH
cortisol + NAD+
cortisone + NADH
cortisone + NADPH + H+
cortisol + NADP+
additional information
?
-
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
isozyme 11beta-HSD1
-
-
?
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
-
i.e. cortisol
i.e. cortisone
?
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
-
i.e. cortisol
i.e. cortisone
-
r
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone
-
-
r
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone, clear but not exclusive preference for NAD+, only oxidative activity
-
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone, significant higher rate of conversion for 11-beta-HSD2 than for 11-beta-HSD1
-
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone
-
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone, no enzyme activity in reverse reaction direction
-
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
-
i.e. corticosterone
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
-
i.e. corticosterone
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
-
isoform 11beta-HSD2
-
r
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
-
i.e. corticosterone
-
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
-
i.e. cortisone
i.e. cortisol
ir
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
-
important role in modulating mineralocorticoid and glucocorticoid receptor occupancy by glucocorticoids
i.e. cortisol
ir
corticosterone + beta-NAD+
11-dehydrocorticosterone + beta-NADH
-
-
-
r
corticosterone + beta-NAD+
11-dehydrocorticosterone + beta-NADH
-
-
-
-
r
corticosterone + beta-NAD+
11-dehydrocorticosterone + beta-NADH
-
-
-
-
r
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
-
-
-
?
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
-
-
-
ir
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
-
-
-
ir
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
-
-
-
?
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
-
-
-
ir
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
isozyme 11beta-HSD2
-
-
?
cortisol + beta-NAD+
cortisone + beta-NADH
-
-
-
r
cortisol + beta-NAD+
cortisone + beta-NADH
-
-
-
-
r
cortisol + beta-NAD+
cortisone + beta-NADH
-
-
-
-
r
cortisol + NAD+
cortisone + NADH
-
-
-
?
cortisol + NAD+
cortisone + NADH
-
pathway overview
-
-
ir
cortisol + NAD+
cortisone + NADH
-
-
-
-
ir
cortisol + NAD+
cortisone + NADH
-
-
-
-
ir
cortisol + NAD+
cortisone + NADH
-
oxidase that inactivates glucocorticoids to their 11-oxo derivatives
-
-
?
cortisol + NAD+
cortisone + NADH
-
inactivation of the biologically active glucocorticoid
-
-
r
cortisol + NAD+
cortisone + NADH
isozyme 11beta-HSD2
-
-
ir
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2 catalyzes the oxidative reaction with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH
isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2, inactivation of cortisol, which interacts with the mineralocorticoid receptor, isozyme 11beta-HSD2 inhibition leads to stimulation of sodium and water reabsorption and to an increase of the intravascular volume that suppresses renin and secondarily an increase of blood pressure
-
-
?
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2 catalyzes the reverse reaction 11beta-HSD1 with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2 catalyzes the reverse reaction of 11-beta-HSD1 with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH
isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH
-
-
-
-
?
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2 highly prefers the oxidation of cortisol
-
-
r
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2 is involved in inactivation of glucocorticoids, forskolin is involved in regulation of isozyme 11beta-HSD2 via intracellular cAMP
-
-
ir
cortisol + NAD+
cortisone + NADH
-
-
-
-
?
cortisol + NAD+
cortisone + NADH
isozyme 11beta-HSD2 catalyzes the reverse reaction of 11beta-HSD1 with cofactor NAD+
-
-
ir
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1, activation
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
isozyme 11beta-HSD1, activation
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
isozyme 11beta-HSD1, activation
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
isozyme 11beta-HSD1, activation
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1, activation
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1, activation
-
-
?
additional information
?
-
the enzyme plays a role in spermatogenesis
-
-
?
additional information
?
-
-
enzyme inhibition affects the glucocorticoid- and dexamethasone-mediated regulation of surfactant protein A metabolism, overview
-
-
?
additional information
?
-
-
proinflammatory cytokines inhibit placental isozyme 11beta-HSD2 activity through Ca2+ and cAMP pathways, overview
-
-
?
additional information
?
-
-
effects of hypertension on cardiac steroid metabolism, overview
-
-
?
additional information
?
-
-
estradiol has a regulatory function on the isozymes in the liver, isozyme 11beta-HSD1 expression is about 30% reduced in castrated male rats, while expression of isozyme 11beta-HSD2 is increased, overview
-
-
?
additional information
?
-
the enzyme plays a role in control of cortisol and spermatogenesis
-
-
?
additional information
?
-
-
physiological role of 11beta-hydroxysteroid dehydrogenase in limiting any local actions of glucocorticoids within the reproductive tissues
-
-
?