1.1.1.B40: 11beta-hydroxysteroid dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about 11beta-hydroxysteroid dehydrogenase (NAD+), go to the full flat file.

Reaction

an 11beta-hydroxysteroid
+
NAD+
=
an 11-oxosteroid
+
NADH
+
H+

Synonyms

11 beta-hydroxysteroid dehydrogenase, 11 beta-hydroxysteroid dehydrogenase type 2, 11-beta-HSD2, 11beta hydroxysteroid dehydrogenase type 2, 11beta-HSD, 11beta-HSD 2, 11beta-HSD type 2, 11beta-HSD1, 11beta-HSD2, 11beta-HSD2 (oxidase) NAD+, 11beta-hydroxysteroid dehydrogenase 2, 11beta-hydroxysteroid dehydrogenase isoforms 2, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type-2, 11beta-hydroxysteroid dehydrogenases type 2, 11beta-OHSD, 11betaHSD2, 7-alpha-HCD, 7-alpha-hydroxycholesterol dehydrogenase, corticosteroid 11-beta-dehydrogenase isozyme 1, HSD 2, isozyme 11beta-HSD2, More, NAD(+)-dependent 11beta-dehydrogenase, NAD+-dependent 11beta-hydroxysteroid dehydrogenase 2, type 2 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B40 11beta-hydroxysteroid dehydrogenase (NAD+)

IC50 Value

IC50 Value on EC 1.1.1.B40 - 11beta-hydroxysteroid dehydrogenase (NAD+)

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00061 - 0.00105
(+)-gossypol
0.00088 - 0.00105
(+/-)-gossypol
0.00133 - 0.0019
(-)-gossypol
0.0000049
(3alpha,18beta,20beta)-3-methoxyamino-11-oxo-olean-12-en-29-oic acid
Homo sapiens
-
pH not specified in the publication, 37°C
0.00075
(3beta)-3-(acetyloxy)-11-oxoolean-12-en-30-oic acid
Homo sapiens
-
pH not specified in the publication, 37°C
0.0000029
(3beta)-30-[hydroxy(methyl)amino]-11,30-dioxoolean-12-en-3-yl acetate
Homo sapiens
-
pH 7.4, 37°C
0.000122
(3beta)-N,3-dihydroxy-11-oxoolean-12-en-30-amide
Homo sapiens
-
pH not specified in the publication, 37°C
0.000458
(3beta,18beta,20beta)-3-(acetylamino)-11-oxo-olean-12-en-29-oic acid
Homo sapiens
-
pH not specified in the publication, 37°C
0.0000611
(3beta,18beta,20beta)-3-acetoxy-N-hydroxy-11-oxo-olean-12-en-29-amide
Homo sapiens
-
pH not specified in the publication, 37°C
0.0000029
(3beta,18beta,20beta)-3-acetoxy-N-methyl-N-hydroxy-11-oxoolean-12-en-29-amide
Homo sapiens
-
pH not specified in the publication, 37°C
0.00213
(3beta,18beta,20beta)-3-hydroxy-N-methoxy-11-oxo-olean-12-en-29-amide
Homo sapiens
-
pH not specified in the publication, 37°C
0.0000145
(3beta,18beta,20beta)-3-methoxyamino-11-oxo-olean-12-en-29-oic acid
Homo sapiens
-
pH not specified in the publication, 37°C
0.000268
(3E)-3-(methoxyimino)-11-oxoolean-12-en-30-oic acid
Homo sapiens
-
pH not specified in the publication, 37°C
0.0000069
(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-4,4,6a,6b,8a,11,14b-heptamethyl-11-[(methylsulfonyl)amino]-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl acetate
Homo sapiens
-
pH 7.4, 37°C
0.00047
11-dehydrocortisterone
Ovis aries
-
pH 8.4, 37°C
0.001
11-deoxycorticosterone
Ovis aries aries
-
IC50: 0.001 mM
0.008
11-oxo-3beta,5alpha-tetrathydrotestosterone
Ovis aries
-
pH 8.4, 37°C
0.0015
11-oxo-allopregnanolone
Ovis aries
-
pH 8.4, 37°C
0.0004
11-oxo-progesterone
Ovis aries
-
pH 8.4, 37°C
0.00135
11-oxo-testosterone
Ovis aries
-
pH 8.4, 37°C
0.000061
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione
Homo sapiens
-
i.e. cortisol, pH and temperature not specified in the publication
0.0000051
11beta,21-dihydroxypregn-4-en-3,20-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.00012
11beta-hydroxy-allopregnanolone
Ovis aries
-
pH 8.4, 37°C
0.0045
11beta-hydroxyandrostanediol
Ovis aries
-
pH 8.4, 37°C
0.0078
11beta-hydroxyandrostenedione
Ovis aries
-
pH 8.4, 37°C
0.00005
11beta-hydroxyprogesterone
Ovis aries
-
pH 8.4, 37°C
0.00035
11beta-hydroxytestosterone
Ovis aries
-
pH 8.4, 37°C
0.000257
18beta-glycyrrhetinic acid
Homo sapiens
-
37°C, pH not specified in the publication
0.000329
3,11-dioxoolean-12-en-30-oic acid
Homo sapiens
-
pH not specified in the publication, 37°C
5.6
3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate
Homo sapiens
-
pH and temperature not specified in the publication
0.0008
3alpha,5alpha-tetrahydro-dehydrocortisterone
Ovis aries
-
pH 8.4, 37°C
0.0005
3alpha,5alpha-tetrahydroaldosterone
Ovis aries
-
pH 8.4, 37°C
0.00026
3alpha,5alpha-tetrahydrocorticosterone
Ovis aries
-
pH 8.4, 37°C
0.008
3alpha,5alpha-tetrahydrocortisol
Ovis aries
-
pH 8.4, 37°C
0.000097 - 0.254
3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid
0.0235
4-n-octylphenol
Homo sapiens
-
inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C
0.0203
4-nonylphenol
Homo sapiens
-
inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C
0.00035
4-pregnen-11,17-diol-3,20-dione
Ovis aries aries
-
IC50: 0.00035 mM
0.0001
4-pregnen-11alpha-ol-3,20-dione
Ovis aries aries
-
IC50: 0.0001 mM
0.00005
4-pregnen-11beta-ol-3,20-dione
Ovis aries aries
-
IC50: 0.00005 mM
0.047
4-pregnen-17alpha-ol-3,20-dione
Ovis aries aries
-
IC50: 0.047 mM
0.007
4-pregnen-20alpha-ol-3-one
Ovis aries aries
-
IC50: 0.007 mM
0.008
4-pregnen-20beta-ol-3-one
Ovis aries aries
-
IC50: 0.008 mM
0.001
4-pregnen-21-ol-3,20-dione
Ovis aries aries
-
IC50: 0.001 mM
0.0004
4-pregnen-3,11,20-trione
Ovis aries aries
-
IC50: 0.0004 mM
0.0011
4-pregnen-3,20-dione
Ovis aries aries
-
IC50: 0.0011 mM
0.0089
4-t-octylphenol
Homo sapiens
-
inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C
0.0001
5-pregnen-3beta,11beta-diol-20-one
Ovis aries aries
-
IC50: 0.0001 mM
0.00015
5alpha-dihydrocorticosterone
Ovis aries
-
pH 8.4, 37°C
0.00035
5alpha-pregnan-11alpha-ol-3,20-dione
Ovis aries aries
-
IC50: 0.00035 mM
0.0031
5alpha-pregnan-11beta,17alpha,21-triol-3,20-dione
Ovis aries aries
-
IC50: 0.0031 mM
0.00015
5alpha-pregnan-11beta,21-diol-3,20-dione
Ovis aries aries
-
IC50: 0.00015 mM
0.008
5alpha-pregnan-3alpha,11beta,17alpha,21-tetrol-20-one
Ovis aries aries
-
IC50: 0.008 mM
0.00026
5alpha-pregnan-3alpha,11beta,21-triol-20-one
Ovis aries aries
-
IC50: 0.00026 mM
0.00012
5alpha-pregnan-3alpha,11beta-diol-20-one
Ovis aries aries
-
IC50: 0.00012 mM
0.0055
5alpha-pregnan-3alpha,17alpha,21-triol-11,20-dione
Ovis aries aries
-
IC50: 0.0055 mM
0.0008
5alpha-pregnan-3alpha,21-diol-11,20-dione
Ovis aries aries
-
IC50: 0.0008 mM
0.0024
5alpha-Pregnan-3alpha,21-diol-20-one
Ovis aries aries
-
IC50: 0.0024 mM
0.008
5alpha-pregnan-3alpha-ol-20-one
Ovis aries aries
-
IC50: 0.008 mM
0.00002 - 0.00005
carbenoxolone
0.513
chenodeoxycholic acid
Cavia porcellus
-
IC50: 0.513 mM
3.529
cholic acid
Cavia porcellus
-
IC50: 3.529 mM
0.0089
dexamethasone
Homo sapiens
-
pH and temperature not specified in the publication
0.01369
di-n-butyl phthalate
Rattus norvegicus
-
-
0.03264 - 0.0465
dicyclohexyl phthalate
0.08559
dipropyl phthalate
Rattus norvegicus
-
-
0.452
Ethacrynic acid
Cavia porcellus
-
IC50: 0.452 mM
0.059
Furosemide
Cavia porcellus
-
IC50: 0.059 mM, competitive
0.0000024 - 0.000257
glycyrrhetinic acid
0.00000071
glycyrrhizinic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00000071
glycyrrhizininc acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.1108 - 0.1218
mono (2-ethylhexyl) phthalate
0.0168 - 0.3279
mono-(2-ethylhexyl) phthalate
0.336
naringenin
Cavia porcellus
-
IC50: 0.336 mM
2.373
naringin
Cavia porcellus
-
IC50: 2.373 mM
0.000048 - 0.000293
perfluorooctane sulfonate
1.358
Phenylbutazone
Cavia porcellus
-
IC50: 1.358 mM
1.395
sistosterol
Cavia porcellus
-
IC50: 1.395 mM
0.01
sterenin A
Homo sapiens
-
value above, pH not specified in the publication, 26°C
0.01
sterenin B
Homo sapiens
-
value above, pH not specified in the publication, 26°C
0.01
sterenin C
Homo sapiens
-
value above, pH not specified in the publication, 26°C
0.01
sterenin D
Homo sapiens
-
value above, pH not specified in the publication, 26°C
1.968
stigmasterol
Cavia porcellus
-
IC50: 1.968 mM
0.0165
tributyltin
Homo sapiens
-
inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C
0.0033
Triphenyltin
Homo sapiens
-
inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C
additional information
(1S,2R,3S,5R,6R)-4-methylidene-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]heptane-2,3,5-triol