1.1.1.B40: 11beta-hydroxysteroid dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about 11beta-hydroxysteroid dehydrogenase (NAD+), go to the full flat file.

Reaction

Synonyms

11 beta-hydroxysteroid dehydrogenase, 11 beta-hydroxysteroid dehydrogenase type 2, 11-beta hydroxysteroid dehydrogenase type 1, 11-beta hydroxysteroid dehydrogenase type 2, 11-beta-HSD2, 11beta hydroxysteroid dehydrogenase type 2, 11beta-HSD, 11beta-HSD 2, 11beta-HSD type 2, 11beta-HSD1, 11beta-HSD2, 11beta-HSD2 (oxidase) NAD+, 11beta-HSD2/HSD11B2, 11beta-hydroxysteroid dehydrogenase 2, 11beta-hydroxysteroid dehydrogenase isoforms 2, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type-2, 11beta-hydroxysteroid dehydrogenases type 2, 11beta-OHSD, 11betaHSD2, 11HSD1, 7-alpha-HCD, 7-alpha-hydroxycholesterol dehydrogenase, corticosteroid 11-beta-dehydrogenase isozyme 1, HSD 2, HSD11B type 1, HSD11B type 2, Hsd11B2, isozyme 11beta-HSD2, More, NAD(+)-dependent 11beta-dehydrogenase, NAD+-dependent 11beta-hydroxysteroid dehydrogenase 2, type 2 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.B40 11beta-hydroxysteroid dehydrogenase (NAD+)

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Results	in table
8	Activating Compound
9	AA Sequence
9	Application
27	Cloned(Commentary)
68	Cofactor
1	Crystallization (Commentary)
448	Disease/ Diagnostics
4	Expression
11	General Information
127	IC50 Value
251	Inhibitors
57	Ki Value [mM]
37	KM Value [mM]
20	Localization
15	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
258	Organism
20	pH Optimum
1	pH Range
2	Purification (Commentary)
8	Reaction
3	Reaction Type
91	Reference
149	Source Tissue
12	Specific Activity [micromol/min/mg]
2	Storage Stability
118	Substrates and Products (Substrate)
17	Subunits
119	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
1	Temperature Stability [°C]

Expression

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Expression on EC 1.1.1.B40 - 11beta-hydroxysteroid dehydrogenase (NAD+)

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

11HSD1 expression is increased by stress in the hippocampus, i.e. in the limbic structure that is activated by stress, effect of stress on the expression of 11HSD1 in the ventral and dorsal region of the CA1 hippocampus in three different rat strains with diverse responses to stress: Fisher 344, Lewis and Wistar. Stress stimulates 11HSD1 in the ventral but not dorsal CA1 hippocampus of Fisher 344 but not Lewis or Wistar rats

Rattus norvegicus

P16232

743428

expression of placental 11beta-HSD2 is regulated at both transcriptional and posttranscriptional levels. JNK inhibitor SP600125 has no effect on 11beta-HSD2 isozyme expression

Homo sapiens

P80365

742040

isozyme expression analysis

Sus scrofa

Q8MKG1

668505

p38 MAPK enhances placental 11beta-HSD2 expression by a posttranscriptional mechanism. ERK1/2 inhibitor U0126 induces the enzyme expression in trophoblasts. siRNA-mediated knockdown of ERK1/2 expression leads to a similar increase in levels of 11beta-HSD2 protein, as seen in cells treated with the ERK1/2 pharmacological inhibitor

Homo sapiens

P80365

742040