1.1.1.B40: 11beta-hydroxysteroid dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about 11beta-hydroxysteroid dehydrogenase (NAD+), go to the full flat file.

Reaction

an 11beta-hydroxysteroid
+
NAD+
=
an 11-oxosteroid
+
NADH
+
H+

Synonyms

11 beta-hydroxysteroid dehydrogenase, 11 beta-hydroxysteroid dehydrogenase type 2, 11-beta hydroxysteroid dehydrogenase type 1, 11-beta hydroxysteroid dehydrogenase type 2, 11-beta-HSD2, 11beta hydroxysteroid dehydrogenase type 2, 11beta-HSD, 11beta-HSD 2, 11beta-HSD type 2, 11beta-HSD1, 11beta-HSD2, 11beta-HSD2 (oxidase) NAD+, 11beta-hydroxysteroid dehydrogenase 2, 11beta-hydroxysteroid dehydrogenase isoforms 2, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type-2, 11beta-hydroxysteroid dehydrogenases type 2, 11beta-OHSD, 11betaHSD2, 11HSD1, 7-alpha-HCD, 7-alpha-hydroxycholesterol dehydrogenase, corticosteroid 11-beta-dehydrogenase isozyme 1, HSD 2, HSD11B type 1, HSD11B type 2, Hsd11B2, isozyme 11beta-HSD2, More, NAD(+)-dependent 11beta-dehydrogenase, NAD+-dependent 11beta-hydroxysteroid dehydrogenase 2, type 2 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B40 11beta-hydroxysteroid dehydrogenase (NAD+)

Cloned

Cloned on EC 1.1.1.B40 - 11beta-hydroxysteroid dehydrogenase (NAD+)

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in HEK-293 cell
expression in CHO cells
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expression in CHOP-C4 cells
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expression in HEK-293 cell
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expression in Xenopus oocytes
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expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells
expression of His6-tagged enzyme in Escherichia coli
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expression of isozyme 11beta-HSD1 in HEK-293 cells
gene 11beta-HSDsf, DNA and amino acid sequence determination and analysis, in vitro expression of the enzyme using the wheat germ cell-free protein synthesis system
gene 11HSD1, genotyping, quantitative isozyme expression analysis in brain of different strains
gene HSD11B1, variation exists in placental DNA methylation of HSD11B1, the variation is associated with mRNA expression of the gene, real-time PCR expression analysis. No correlation between HSD11B1 CpG1 and expression, and a strong positive correlation between CpG2 and expression. HSD11B1 gene expression is positively correlated with a single CpG site; gene HSD11B2, variation exists in placental DNA methylation of HSD11B2, the variation is associated with mRNA expression of the gene, real-time PCR expression analysis. Sex-specific correlation between HSD11B2 methylation levels and expression, with females displaying a much stronger correlation between the two factors with no correlation for males, there is no sex-specific role of methylation in infant birth weight in either time points in pregnancy. HSD11B2 expression is negatively correlated with the mean methylation of four CpG sites within its promoter
gene HSD11B2, DNA and amino acid sequence determination and analysis, microsatellite genotyping
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gene HSD11B2, two-step real-time quantitative RT-PCR isozyme 11beta-HSD2 expression analysis
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isoform 11beta-HSD2, expression in Sf9 cell
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isozyme 11beta-HSD1, expression in HEK-293 cells
overexpressed in HEK-293 cell
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stable expression of isozymes 11beta-HSD1 and 11beta-HSD2 in CHO cells
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the 11beta-HSD2 enzyme is produced in HEK-293 cells
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