1.1.1.B40: 11beta-hydroxysteroid dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about 11beta-hydroxysteroid dehydrogenase (NAD+), go to the full flat file.

Reaction

an 11beta-hydroxysteroid
+
NAD+
=
an 11-oxosteroid
+
NADH
+
H+

Synonyms

11 beta-hydroxysteroid dehydrogenase, 11 beta-hydroxysteroid dehydrogenase type 2, 11-beta-HSD2, 11beta hydroxysteroid dehydrogenase type 2, 11beta-HSD, 11beta-HSD 2, 11beta-HSD type 2, 11beta-HSD1, 11beta-HSD2, 11beta-HSD2 (oxidase) NAD+, 11beta-hydroxysteroid dehydrogenase 2, 11beta-hydroxysteroid dehydrogenase isoforms 2, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type-2, 11beta-hydroxysteroid dehydrogenases type 2, 11beta-OHSD, 11betaHSD2, 7-alpha-HCD, 7-alpha-hydroxycholesterol dehydrogenase, corticosteroid 11-beta-dehydrogenase isozyme 1, HSD 2, isozyme 11beta-HSD2, More, NAD(+)-dependent 11beta-dehydrogenase, NAD+-dependent 11beta-hydroxysteroid dehydrogenase 2, type 2 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B40 11beta-hydroxysteroid dehydrogenase (NAD+)

Cloned

Cloned on EC 1.1.1.B40 - 11beta-hydroxysteroid dehydrogenase (NAD+)

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in HEK-293 cell
expression in CHO cells
-
expression in CHOP-C4 cells
-
expression in HEK-293 cell
-
expression in Xenopus oocytes
-
expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells
expression of His6-tagged enzyme in Escherichia coli
-
expression of isozyme 11beta-HSD1 in HEK-293 cells
gene 11beta-HSDsf, DNA and amino acid sequence determination and analysis, in vitro expression of the enzyme using the wheat germ cell-free protein synthesis system
gene HSD11B2, DNA and amino acid sequence determination and analysis, microsatellite genotyping
-
isoform 11beta-HSD2, expression in Sf9 cell
-
isozyme 11beta-HSD1, expression in HEK-293 cells
overexpressed in HEK-293 cell
-
stable expression of isozymes 11beta-HSD1 and 11beta-HSD2 in CHO cells
-
the 11beta-HSD2 enzyme is produced in HEK-293 cells
-