1.1.1.B38: hydroxymethylglutaryl-CoA reductase [NAD(P)H]

This is an abbreviated version, for detailed information about hydroxymethylglutaryl-CoA reductase [NAD(P)H], go to the full flat file.

Reaction

mevalonate
+
CoA
+ 2 NAD(P)+ =
3-hydroxy-3-methylglutaryl-CoA
+ 2 NAD(P)H + 2 H+

Synonyms

AF1736, HMG-CoA reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B38 hydroxymethylglutaryl-CoA reductase [NAD(P)H]

Substrates Products

Substrates Products on EC 1.1.1.B38 - hydroxymethylglutaryl-CoA reductase [NAD(P)H]

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
mevalonate + CoA + 2 NAD+
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
show the reaction diagram
optimal activity using NADP(H) occurs at pH from 1 to 3 units more acidic than that observed using NAD(H)
-
-
r
mevalonate + CoA + 2 NADP+
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
show the reaction diagram
slight preference for NAD(H) versus NADP(H). Optimal activity using NADP(H) occurs at a pH from 1 to 3 units more acidic than that observed using NAD(H)
-
-
r