1.1.1.B38: hydroxymethylglutaryl-CoA reductase [NAD(P)H]

This is an abbreviated version, for detailed information about hydroxymethylglutaryl-CoA reductase [NAD(P)H], go to the full flat file.

Reaction

mevalonate
+
CoA
+ 2 NAD(P)+ =
3-hydroxy-3-methylglutaryl-CoA
+ 2 NAD(P)H + 2 H+

Synonyms

AF1736, HMG-CoA reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B38 hydroxymethylglutaryl-CoA reductase [NAD(P)H]

Cofactor

Cofactor on EC 1.1.1.B38 - hydroxymethylglutaryl-CoA reductase [NAD(P)H]

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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
slight preference for NAD(H) versus NADP(H). Optimal activity using NADP(H) occurrs at a pH from 1 to 3 units more acidic than that observed using NAD(H). Each coenzyme acts as a competitive inhibitor of the other
NADH
slight preference for NAD(H) versus NADP(H). Optimal activity using NADP(H) occurrs at a pH from 1 to 3 units more acidic than that observed using NAD(H). Each coenzyme acts as a competitive inhibitor of the other
NADP+
slight preference for NAD(H) versus NADP(H). Optimal activity using NADP(H) occurrs at a pH from 1 to 3 units more acidic than that observed using NAD(H). Each coenzyme acts as a competitive inhibitor of the other
NADPH
slight preference for NAD(H) versus NADP(H). Optimal activity using NADP(H) occurrs at a pH from 1 to 3 units more acidic than that observed using NAD(H). Each coenzyme acts as a competitive inhibitor of the other