1.1.1.B20: meso-2,3-butandiol dehydrogenase

This is an abbreviated version, for detailed information about meso-2,3-butandiol dehydrogenase, go to the full flat file.

Reaction

(2R,3S)-butane-2,3-diol
+
NAD+
=
acetoin
+
NADH
+
H+

Synonyms

2,3-BD dehydrogenase, ARA1, BDH, meso-2,3-BDH, meso-2,3-butanediol dehydrogenase, meso-BD, NAD(H)-dependent meso-2,3-BDH, NAD(H)-dependent meso-2,3-butanediol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B20 meso-2,3-butandiol dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.B20 - meso-2,3-butandiol dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2S,3S)-2,3-butanediol + NAD+
(3S)-acetoin + NADH
show the reaction diagram
-
(2S,3S)-2,3-butanediol is a poor substrate
-
-
?
(2S,3S)-2,3-butanediol + NAD+
(3S)-acetoin + NADH + H+
show the reaction diagram
(3R)-acetoin + NADH + H+
meso-2,3-butanediol + NAD+
show the reaction diagram
(3S)-acetoin + NADH + H+
(2S,3S)-2,3-butanediol + NAD+
show the reaction diagram
1,2-pentanediol + NADH + H+
?
show the reaction diagram
1,2-propandiol + NADH + H+
?
show the reaction diagram
low activity
-
-
?
2 (R,S)-acetoin + 2 NADPH + 2 H+
(2S,3S)-2,3-butanediol + meso-2,3-butanediol + NADP+
show the reaction diagram
-
-
Ara1p is selective toward the acetoin carbonyl group, leading to an S-alcohol
-
r
4-methyl-2-pentanone + NADH + H+
4-methyl-2-pentanol + NAD+
show the reaction diagram
diacetyl + NADH + H+
(3S)-acetoin + NAD+
show the reaction diagram
-
-
-
?
glycerol + NADH + H+
?
show the reaction diagram
low activity
-
-
?
L-acetoin + NADH
L-2,3-butanediol + NAD+
show the reaction diagram
-
-
-
?
meso-2,3-butanediol + NAD+
(3R)-acetoin + NADH + H+
show the reaction diagram
-
-
-
r
meso-2,3-butanediol + NAD+
acetoin + NADH
show the reaction diagram
-
-
-
-
?
meso-2,3-butanediol + NAD+
acetoin + NADH + H+
show the reaction diagram
-
-
-
-
?
additional information
?
-