1.1.1.B18: L-1-amino-2-propanol dehydrogenase

This is an abbreviated version, for detailed information about L-1-amino-2-propanol dehydrogenase, go to the full flat file.

Reaction

(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
+
NADP+
=
(2S)-2-(methylamino)-1-phenylpropan-1-one
+
NADPH
+
H+

Synonyms

AADH, amino alcohol dehydrogenase, L-1-amino-2-propanol dehydrogenase, NADP+-dependent aminoalcohol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B18 L-1-amino-2-propanol dehydrogenase

Cloned

Cloned on EC 1.1.1.B18 - L-1-amino-2-propanol dehydrogenase

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene aadh, DNA and amino acid sequence determination and analysis, expression analysis
gene aadh, DNA and amino acid sequence determination and analysis, expression in Escherichia coli JM109 leading to a 10.4fold increase in specific activity as to catalysis of the reduction of (2S)-2-(methylamino)-1-phenylpropan-1-one, as compared with that of Rhodococcus erythropolis strain MAK154 induced by 1-amino-2-propanol. Coexpression of aadh with glucose dehydrogenase gene gdh as cofactor regeneration enzyme, and installation of a system for sufficient production of d-psi-pseudoephedrine from racemic (S)-1-phenyl-2-methylaminopropan-1-one
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