1.1.1.B18: L-1-amino-2-propanol dehydrogenase
This is an abbreviated version!
For detailed information about L-1-amino-2-propanol dehydrogenase, go to the full flat file.
Reaction
Synonyms
AADH, amino alcohol dehydrogenase, L-1-amino-2-propanol dehydrogenase, NADP+-dependent aminoalcohol dehydrogenase
ECTree
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Application
Application on EC 1.1.1.B18 - L-1-amino-2-propanol dehydrogenase
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pharmacology
synthesis
the enzyme produces double chiral aminoalcohols, which are used as pharmaceuticals. The Rhodococcus expression vector, pRET11100, constructed by removing aadh from the pRET1172 plasmid may be useful for bioconversion
pharmacology
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the enzyme produces double chiral aminoalcohols, which are used as pharmaceuticals. The Rhodococcus expression vector, pRET11100, constructed by removing aadh from the pRET1172 plasmid may be useful for bioconversion
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coversion of 1-(3-hydroxyphenyl)-2-(methylamino) ethanone to (S)-phenylephrine with with more than 99% enantiomeric excess, 78% yield and a productivity of 3.9 mmol(S)-phenylepinephrine/l h in 12 h at 30°C and pH 7. The (S)-phenylepinephrine, recovered from reaction mixture by precipitation at pH 11.3, can be converted to (R)-phenylepinephrine by Walden inversion reaction
synthesis
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coversion of 1-(3-hydroxyphenyl)-2-(methylamino) ethanone to (S)-phenylephrine with with more than 99% enantiomeric excess, 78% yield and a productivity of 3.9 mmol(S)-phenylepinephrine/l h in 12 h at 30°C and pH 7. The (S)-phenylepinephrine, recovered from reaction mixture by precipitation at pH 11.3, can be converted to (R)-phenylepinephrine by Walden inversion reaction
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