1.1.1.95: phosphoglycerate dehydrogenase

This is an abbreviated version, for detailed information about phosphoglycerate dehydrogenase, go to the full flat file.

Reaction

3-phospho-D-glycerate
+
NAD+
=
3-phosphonooxypyruvate
+
NADH
+
H+

Synonyms

3-PGDH, 3-phosphoglycerate dehydrogenase, 3-phosphoglyceric acid dehydrogenase, 3PGDH, A10, alpha-phosphoglycerate dehydrogenase, ApPGDH, D-3-phosphoglycerate dehydrogenase, D-3-phosphoglycerate:NAD oxidoreductase, D-phosphoglycerate dehydrogenase, dehydrogenase, phosphoglycerate, EDA9, EhPGDH, glycerate 3-phosphate dehydrogenase, glycerate-1,3-phosphate dehydrogenase, More, NAD-dependent D-3-phosphoglycerate dehydrogenase, PGDH, PGDH1, PGDH2, PGDH3, PGK, Phgdh, phosphoglycerate dehydrogenase, phosphoglycerate kinase, phosphoglycerate oxidoreductase, phosphoglyceric acid dehydrogenase, serA, type 1 D-3-phosphoglycerate dehydrogenase, type III 3-phosphoglycerate dehydrogenase, type IIIK PGDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.95 phosphoglycerate dehydrogenase

Expression

Expression on EC 1.1.1.95 - phosphoglycerate dehydrogenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
HOXA10 is required for enzyme regulation in the endometrium, HOAX antisense expression, siRNA, causes a 4.4fold upregulation of 3-PGDH in endometrial cells
HOXA10 is required for enzyme regulation in the endometrium, HOAX sense expression causes a 2.0fold downregulation of 3-PGDH in endometrial cells
Phgdh knockout mouse embryos demonstrate that free serine and glycine concentrations are decreased markedly in head samples
-
there is no significant change in the mRNA expression level after the incubation with L-serine