1.1.1.94: glycerol-3-phosphate dehydrogenase [NAD(P)+]

This is an abbreviated version, for detailed information about glycerol-3-phosphate dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

sn-glycerol 3-phosphate
+
NAD(P)+
=
glycerone phosphate
+
NAD(P)H
+
H+

Synonyms

CvGPD1, G3PD, G3PDH, GLPD, glycerol 3-phosphate dehydrogenase, glycerol 3-phosphate dehydrogenase (NADP), glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)), GPDH, GpsA, L-glycerol-3-phosphate:NAD(P) oxidoreductase, NAD(P)H-dependent dihydroxyacetone-phosphate reductase, NAD(P)H-dependent glycerol-3-phosphate dehydrogenase, NADP-dependent glycerol-3-phosphate dehydrogenase, RP442, sn-glycerol-3-phosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.94 glycerol-3-phosphate dehydrogenase [NAD(P)+]

Inhibitors

Inhibitors on EC 1.1.1.94 - glycerol-3-phosphate dehydrogenase [NAD(P)+]

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(NH4)2SO4
-
100 mM, 68% inhibition, 10 mM, 8% inhibition
2',5'-ADP
-
-
3,4-dihydroxybutyl 1-phosphonate
-
competitive versus dihydroxyacetone phosphate, binding to a regulatory site
adenosine
-
competitive vs. NAD+
Adenosine diphosphate
-
competitive vs. NAD+
adenosine diphosphoribose
-
competitive vs. NAD+
adenylic acid
-
competitive vs. NAD+
ADP-ribose
-
-
dihydroxyacetone phosphate
-
noncompetitive versus NADP+
DL-glycerol 3-phosphate
-
0.05 mM, 26% inhibition
ethylene glycol phosphate
-
binding to the active site
glyceraldehyde-3-phosphate
competitive inhibitor
glyceric acid 2-phosphate
competitive inhibitor
glycerol 3-phosphate
-
50% inhibition with 0.035 mM, sigmoid inhibition curve, competitive inhibition vs. glycerone phosphate, uncompetitive vs. NADPH
K2PO4-
-
100 mM, 95% inhibition, 10 mM, 27% inhibition
K2SO4
-
100 mM, 60% inhibition
KCl
-
100 mM, 47% inhibition
N1-butylnicotinamide chloride
-
competitive vs. NAD+
N1-decylnicotinamide chloride
-
competitive vs. NAD+
N1-dodecylnicotinamide chloride
-
competitive vs. NAD+
N1-ethylnicotinamide chloride
-
competitive vs. NAD+
N1-heptylnicotinamide chloride
-
competitive vs. NAD+
N1-hexylnicotinamide chloride
-
competitive vs. NAD+
N1-methylnicotinamide chloride
-
competitive vs. NAD+
N1-nonylnicotinamide chloride
-
competitive vs. NAD+
N1-octylnicotinamide chloride
-
competitive vs. NAD+
N1-pentylnicotinamide chloride
-
competitive vs. NAD+
N1-propylnicotinamide chloride
-
competitive vs. NAD+
N1-undecylnicotinamide chloride
-
competitive vs. NAD+
Na2PO4-
-
100 mM, 92% inhibition, 10 mM, 27% inhibition
Na2SO4
-
100 mM, 63% inhibition
NaCl
-
100 mM, 47% inhibition
NADP+
NADPH
-
competitive versus NADP+
NH4Cl
-
100 mM, 37% inhibition
palmitoyl-CoA
-
0.0015 mM, 52% inhibition
phosphoenolpyruvate
competitive inhibitor
sn-glycerol-3-phosphate