glycerol-3-phosphate dehydrogenase [NAD(P)+]

This is an abbreviated version, for detailed information about glycerol-3-phosphate dehydrogenase [NAD(P)+], go to the full flat file.


sn-glycerol 3-phosphate
glycerone phosphate


CvGPD1, G3PD, G3PDH, GLPD, glycerol 3-phosphate dehydrogenase, glycerol 3-phosphate dehydrogenase (NADP), glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)), GPDH, GpsA, L-glycerol-3-phosphate:NAD(P) oxidoreductase, NAD(P)H-dependent dihydroxyacetone-phosphate reductase, NAD(P)H-dependent glycerol-3-phosphate dehydrogenase, NADP-dependent glycerol-3-phosphate dehydrogenase, RP442, sn-glycerol-3-phosphate dehydrogenase


     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
       glycerol-3-phosphate dehydrogenase [NAD(P)+]


Crystallization on EC - glycerol-3-phosphate dehydrogenase [NAD(P)+]

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crystal structure analysis: GlpD comprises two major domains, a soluble extramembraneous C-terminal cap domain (residues 389-501) and a N-terminal FAD-binding region, consisting of the substrate binding and base regions (residues 1-388). The dimeric enzyme is formed by monomers related by a noncrystallographic 2fold axis of symmetry and the dimer comprises the unique asymmetric unit. Electrostatic surface calculations show distinct regions of highly positive patches, located at the base region of the enzyme. These regions are likely involved with the negatively charged membrane phospholipid head groups. The cap domain, at the opposite side, exhibits highly negatively electrostatic potential, with large hydrophobic patches between these two distal regions of the enzyme, forming membrane interaction and proposed UQ-binding surfaces; structure of the native enzyme and in complex with dihydroxyacetone phosphate (2.1 A) and in separate complexes with substrate analogues, glyceraldehyde-3-phosphate (2.9 A), glyceric acid 2-phosphate (2.3 A), and phosphoenolpyruvate (2.1 A) are determined. Additionally, in complex with ubiquinone analogues, menadione (2.6 A) and 2-n-heptyl-4-hydroxyquinoline N-oxide (2.9 A)