1.1.1.93: tartrate dehydrogenase

This is an abbreviated version, for detailed information about tartrate dehydrogenase, go to the full flat file.

Reaction

Tartrate
+
NAD+
=
Oxaloglycolate
+
NADH
+
H+

Synonyms

dehydrogenase, tartrate, mesotartrate dehydrogenase, TDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.93 tartrate dehydrogenase

Engineering

Engineering on EC 1.1.1.93 - tartrate dehydrogenase

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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D225A
-
mutation in metal ion-binding ligand, 20fold decrease in metal ion-binding affinity and a two-orders-of-magnitude decrease in catalysis
D250A
-
mutation in metal ion-binding ligand, 10fold decrease in metal ion-binding affinity and a two-orders-of-magnitude decrease in catalysis
R108L
-
1.3% of wild-type catalytic rate
R108Q
-
8.7% of wild-type catalytic rate
R98L
-
mutant is not expressed in stable form
R98Q
-
2.6% of wild-type catalytic rate