1.1.1.91: aryl-alcohol dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about aryl-alcohol dehydrogenase (NADP+), go to the full flat file.

Reaction

An aromatic alcohol
+
NADP+
=
an aromatic aldehyde
+
NADPH
+
H+

Synonyms

AAD, Aad1p, ADH, aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate) coniferyl alcohol dehydrogenase, aryl-alcohol dehydrogenase, NADPH-linked benzaldehyde reductase, SDR A5, SDR B3, short-chain dehydrogenase/reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.91 aryl-alcohol dehydrogenase (NADP+)

Crystallization

Crystallization on EC 1.1.1.91 - aryl-alcohol dehydrogenase (NADP+)

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Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
crystal structure of the apoenzyme as well as its NADP+-bound state with resolutions down to 2.8 A. ADH displays a homotetrameric quaternary structure that can be described as a dimer of homodimers while in each subunit a seven-stranded parallel beta-sheet, flanked by three alpha-helices on each side, forms a Rossmann fold-type dinucleotide binding domain. NADP+ specificity is largely governed by the residues Asn15, Gly37, Arg38, and Arg39