1.1.1.88: hydroxymethylglutaryl-CoA reductase

This is an abbreviated version, for detailed information about hydroxymethylglutaryl-CoA reductase, go to the full flat file.

Reaction

(R)-mevalonate
+
CoA
+ 2 NAD+ =
3-hydroxy-3-methylglutaryl-CoA
+ 2 NADH + 2 H+

Synonyms

3-hydroxy-3-methylglutaryl CoA reductase 1, 3-hydroxy-3-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, HMG-CoA reductase, hydroxymethylglutaryl coenzyme A reductase, Mt HMGR1, NADH-dependent HMG-CoA reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.88 hydroxymethylglutaryl-CoA reductase

Storage Stability

Storage Stability on EC 1.1.1.88 - hydroxymethylglutaryl-CoA reductase

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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-180°C, 400 mM KCl, 12 months
-
-180°C, 400 mM KCl, 24 months
-
-20°C stable to repeated freezing and thawing
-
-20°C unstable to repeated freezing and thawing
-
0°C, 10 hours, 5% loss of activity
-