1.1.1.88: hydroxymethylglutaryl-CoA reductase

This is an abbreviated version, for detailed information about hydroxymethylglutaryl-CoA reductase, go to the full flat file.

Reaction

(R)-mevalonate
+
CoA
+ 2 NAD+ =
3-hydroxy-3-methylglutaryl-CoA
+ 2 NADH + 2 H+

Synonyms

3-hydroxy-3-methylglutaryl CoA reductase 1, 3-hydroxy-3-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, HMG-CoA reductase, hydroxymethylglutaryl coenzyme A reductase, Mt HMGR1, NADH-dependent HMG-CoA reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.88 hydroxymethylglutaryl-CoA reductase

Specific Activity

Specific Activity on EC 1.1.1.88 - hydroxymethylglutaryl-CoA reductase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.011
-
H381A-mutant, mevalonate acylation
0.029
-
H381N-mutant, mevalonate acylation
0.041
-
H381Q-mutant, mevalonate acylation
0.091
-
H381K-mutant, mevalonate acylation
0.163
-
mevalonate acylation
0.17
-
mevalonate acylation
0.922
-
wild-type enzyme, [14C]-mevalonate acylation
1.203
-
S871A [14C]-mevalonate acylation
2.7
-
reverse reaction, pH 7.9, 30C
2.73
-
forward reaction, pH 7.9, 30C
4.87
-
reverse reaction, pH 7.9, 30C
11.94
-
forward reaction, pH 7.9, 30C
18
-
mevalonate acylation pH 8.1
20.3
-
mevalonate acylation pH 11
54.2
-
cysteine-free mutant, mevalonate acylation
60.5
-
mevalonate acylation
65.6
-
C156A-mutant, mevalonate acylation
70.5
-
wild-type enzyme, mevalonate acylation
77.7
-
C296A-mutant, mevalonate acylation
additional information
-
after a dietary intake of docosahexaenoic acid ethyl ester (DHA-EE) brain HMG-CoA reductase activity and brain cholesterol content significantly increases with age. Hepatic HMG-CoA reductase activity and the cholesterol content of both adult and aged mice are reduced in DHA-EE diet groups compared with linoleic acid ethyl ester