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1.1.1.88: hydroxymethylglutaryl-CoA reductase

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA reductase, go to the full flat file.

Word Map on EC 1.1.1.88

Reaction

(R)-mevalonate
+
CoA
+ 2 NAD+ =
3-hydroxy-3-methylglutaryl-CoA
+ 2 NADH + 2 H+

Synonyms

3-hydroxy-3-methylglutaryl CoA reductase 1, 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, HMG-CoA reductase, HMGCoAR, HMGR, hydroxymethylglutaryl coenzyme A reductase, Mt HMGR1, mvaA, NADH-dependent HMG-CoA reductase, NADH-HMGR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.88 hydroxymethylglutaryl-CoA reductase

KM Value

KM Value on EC 1.1.1.88 - hydroxymethylglutaryl-CoA reductase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.27 - 3.7
(R,S)-mevalonate
0.078
(S)-3-hydroxy-3-methylglutaryl-CoA
pH and temperature not specified in the publication
0.00734
3-hydroxy-3-methylglutaryl-CoA
-
at pH 7.4, temperature not specified in the publication
0.039 - 0.1
CoA
0.03 - 0.5
CoASH
0.05 - 0.3
DL-3-hydroxy-3-methylglutaryl-CoA
0.61 - 36
DL-mevaldate
0.35 - 0.49
DL-mevalonate
0.22 - 0.3
mevalonate
0.06 - 1.23
NAD+
0.0285 - 0.36
NADH
52
NADP+
-
wild-type enzyme, oxidative acylation of mevalonate
0.15
R-mevalonate
-
oxidative acylation of mevalonate
additional information
additional information
kinetic analysis, overview. The enzyme exhibits positive cooperativity toward the substrates of the reductive reaction, but the oxidative reaction exhibits unusual double-saturation kinetics, distinctive among characterized HMG-CoA reductases. The unusual kinetics may arise from the presence of multiple active oligomeric states, each with different Vmax values
-