Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.1.1.88: hydroxymethylglutaryl-CoA reductase

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA reductase, go to the full flat file.

Word Map on EC 1.1.1.88

Reaction

(R)-mevalonate
+
CoA
+ 2 NAD+ =
3-hydroxy-3-methylglutaryl-CoA
+ 2 NADH + 2 H+

Synonyms

3-hydroxy-3-methylglutaryl CoA reductase 1, 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, HMG-CoA reductase, HMGCoAR, HMGR, hydroxymethylglutaryl coenzyme A reductase, Mt HMGR1, mvaA, NADH-dependent HMG-CoA reductase, NADH-HMGR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.88 hydroxymethylglutaryl-CoA reductase

KI Value

KI Value on EC 1.1.1.88 - hydroxymethylglutaryl-CoA reductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.5
3-hydroxy-3-methylglutarate
-
standard conditions, inhibition by substrate analog
35
4-hydroxybutyrate
-
standard conditions, inhibition by substrate analog
3
acetoacetate
-
standard conditions, inhibition by substrate analog
0.8
beta-hydroxybutyrate
-
standard conditions, inhibition by substrate analog
170
citrate
-
at pH 7.4, temperature not specified in the publication
0.28 - 35
lovastin
0.26
mevalonate
-
standard conditions, substrate inhibition