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1.1.1.88: hydroxymethylglutaryl-CoA reductase

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA reductase, go to the full flat file.

Word Map on EC 1.1.1.88

Reaction

(R)-mevalonate
+
CoA
+ 2 NAD+ =
3-hydroxy-3-methylglutaryl-CoA
+ 2 NADH + 2 H+

Synonyms

3-hydroxy-3-methylglutaryl CoA reductase 1, 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, HMG-CoA reductase, HMGCoAR, HMGR, hydroxymethylglutaryl coenzyme A reductase, Mt HMGR1, mvaA, NADH-dependent HMG-CoA reductase, NADH-HMGR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.88 hydroxymethylglutaryl-CoA reductase

Cloned

Cloned on EC 1.1.1.88 - hydroxymethylglutaryl-CoA reductase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
BcHMGR is encoded by a gene between bases 588787 and 590073 on chromosome 2 of the Burkholderia cenocepacia genome, severe rare codon issues occur resulting in truncation products at 23 kD and 35 kD in addition to the expected size of 47.3 kD, successful recombinant expression of His6-tagged enzyme in Escherichia coli
expressed in COS-M6a, monkey
-
expressed in Escherichia coli
-
expressed in Escherichia coli BL21
-
expressed in Escherichia coli BL21(DE3) cells
-
expressed in Escherichia coli JM103
-
expressed in Saccharomyces cerevisiae strain SE5
-
expressed in UT-2, CHO-cells
-
expression in Catharanthus roseus, the hairy roots with higher levels of soluble enzyme, clone 19, have a lower alkaloid and higher sterol content. By contrast, the clone with nonsoluble enzyme activity, clone 236, has a higher alkaloid and lower sterol content
-