1.1.1.88: hydroxymethylglutaryl-CoA reductase

This is an abbreviated version, for detailed information about hydroxymethylglutaryl-CoA reductase, go to the full flat file.

Reaction

(R)-mevalonate
+
CoA
+ 2 NAD+ =
3-hydroxy-3-methylglutaryl-CoA
+ 2 NADH + 2 H+

Synonyms

3-hydroxy-3-methylglutaryl CoA reductase 1, 3-hydroxy-3-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, HMG-CoA reductase, hydroxymethylglutaryl coenzyme A reductase, Mt HMGR1, NADH-dependent HMG-CoA reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.88 hydroxymethylglutaryl-CoA reductase

Activating Compound

Activating Compound on EC 1.1.1.88 - hydroxymethylglutaryl-CoA reductase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
CoA
-
mevaldehyde reduction
docosahexaenoic acid ethyl ester
-
in 18-month-old aged mice but not in 8-month-old mice, HMG-CoA reductase activity is enhanced with dietary intake of docosahexaenoic acid ethyl ester (DHA-EE)
EGTA
-
EGTA causes an increase in levels of enzyme observed on immunoplots
mevastatin
-
The increased accumulation of the enzyme-FLAG using the open-ring form and the closed-ring form of mevastatin is observed. The mevastatin-induced enzyme increases are possibly explained by the inhibition of a feedback-regulated down-regulation due to lowered pools of mevalonate or its product
pantetheine
-
mevaldehyde reduction