1.1.1.82: malate dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about malate dehydrogenase (NADP+), go to the full flat file.

Reaction

(S)-malate
+
NADP+
=
oxaloacetate
+
NADPH
+
H+

Synonyms

(S)-malate dehydrogenase, dehydrogenase, malate (nicotinamide adenine dinucleotide phosphate), malate NADP dehydrogenase, malic dehydrogenase (nicotinamide adenine dinucleotide phosphate), MDH, NADP malate dehydrogenase, NADP-dependent malate dehydrogenase, NADP-linked malate dehydrogenase, NADP-malate dehydrogenase, NADP-malic enzyme, NADP-MDH, NADP-MDH1, NADP-MDH2, NADPH-MDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.82 malate dehydrogenase (NADP+)

Reference

Reference on EC 1.1.1.82 - malate dehydrogenase (NADP+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Isegawa, Y.; Nakano, Y.; Kitaoka, S.
Submitochondrial location and some properties of NAD+- and NADP+-linked malate dehydrogenase in Euglena
Agric. Biol. Chem.
48
549-552
1984
Euglena gracilis, Euglena gracilis SM-ZK
-
Manually annotated by BRENDA team
Johnson, H.S.
NADP-malate dehydrogenase: photoactivation in leaves of plants with Calvin cycle photosynthesis
Biochem. Biophys. Res. Commun.
43
703-709
1971
Hordeum vulgare, Spinacia oleracea
Manually annotated by BRENDA team
Luchetta, P.; Cretin, C.; Gadal, P.
Structure and characterization of the Sorghum vulgare gene encoding NADP-malate dehydrogenase
Gene
89
171-177
1990
Sorghum bicolor
Manually annotated by BRENDA team
Agostino, A.; Jeffrey, P.; Hatch, M.D.
Amino acid sequence and molecular weight of native NADP malate dehydrogenase from the C4 plant Zea mays
Plant Physiol.
98
1506-1510
1992
Zea mays
Manually annotated by BRENDA team
Vairinhos, F.; Simon, J.P.
Purification and molecular forms of NADP+-malate dehydrogenase from two populations of the C4 weed Echinochloa crus-galli (L.) Beauv. (Poaceae)
Plant Sci.
71
173-177
1990
Echinochloa crus-galli
-
Manually annotated by BRENDA team
Miginiac-Maslow, M.; Decottignies, P.; Jacquot, J.P.; Gadal, P.
Regulation of corn leaf NADP-malate dehydrogenase light-activation by the photosynthetic electron flow. Effect of photoinhibition studied in a reconstituted system
Biochim. Biophys. Acta
1017
273-279
1990
Pisum sativum, Spinacia oleracea, Zea mays
-
Manually annotated by BRENDA team
Scheibe, R.; Rudolph, R.; Reng, W.; Jaenicke, R.
Structural and catalytic properties of oxidized and reduced chloroplast NADP-malate dehydrogenase upon denaturation and renaturation
Eur. J. Biochem.
189
581-587
1990
Pisum sativum
Manually annotated by BRENDA team
Cheng, S.H.; Moore, B.D.; Edwards, G.E.; Ku, M.S.B.
Photosynthesis in Flaveria brownii, a C4-like species. Leaf anatomy, characterization of CO2, exchange, compartmentation of photosynthetic enzymes, and metabolism of 14CO2
Plant Physiol.
87
867-873
1988
Flaveria brownii
Manually annotated by BRENDA team
Migniac-Maslow, M.; Cornic, G.; Jacquot, J.P.
Effect of high light intensities on oxygen evolution and the light activation of NADP-malate dehydrogenase in intact spinach chloroplasts
Planta
173
468-473
1988
Spinacia oleracea
Manually annotated by BRENDA team
Fickenscher, K.; Scheibe, R.
Limited proteolysis of inactive tetrameric chloroplast NADP-malate dehydrogenase produces active dimers
Arch. Biochem. Biophys.
260
771-779
1988
Pisum sativum
Manually annotated by BRENDA team
Kagawa, T.; Bruno, P.L.
NADP-malate dehydrogenase from leaves of Zea mays: purification and physical, chemical, and kinetic properties
Arch. Biochem. Biophys.
260
674-695
1988
Zea mays
Manually annotated by BRENDA team
Jawali, N.; Bhagwat, A.S.
Presence of essential histidine residues in NADP-malic enzyme from maize
Phytochemistry
26
1859-1862
1987
Zea mays
-
Manually annotated by BRENDA team
Krimm, I.; Goyer, A.; Issakidis-Bourguet, E.; Miginiac-Maslow, M.; Lancelin, J.M.
Direct NMR observation of the thioredoxin-mediated reduction of the chloroplast NADP-malate dehydrogenase provides a structural basis for the relief of autoinhibition
J. Biol. Chem.
274
34539-34542
1999
Sorghum bicolor
Manually annotated by BRENDA team
Scheibe, R.; Wagenpfeil, D.; Fischer, J.
NADP-malate dehydrogenase activity during photosynthesis in illuminated spinach chloroplasts
J. Plant Physiol.
124
103-110
1986
Spinacia oleracea
-
Manually annotated by BRENDA team
Jacquot, J.P.; Decottignies, P.
Further evidence for a role of sulfhydryl in the thioredoxin dependent activation of corn NADP-malate dehydrogenase
FEBS Lett.
209
87-91
1986
Zea mays
-
Manually annotated by BRENDA team
Nakamoto, H.; Edwards, G.E.
Light activation of pyruvate, Pi dikinase and NADP-malate dehydrogenase in mesophyll protoplasts in maize
Plant Physiol.
82
312-315
1986
Zea mays
Manually annotated by BRENDA team
Edwards, G.E.; Nakamoto, H.; Burnell, J.N.; Hatch, M.D.
Pyruvate, Pi dikinase and NADP-malate dehydrogenase in C4 photosynthesis: properties and mechanism of light/dark regulation
Annu. Rev. Plant Physiol.
36
255-286
1985
Pisum sativum, Zea mays
-
Manually annotated by BRENDA team
Scheibe, R.; Fickenscher, K.; Ashton, A.R.
Studies on the mechanism of the reductive activation of NADP-malate dehydrogenase by thioredoxin m and low-molecular-weight thiols
Biochim. Biophys. Acta
870
191-197
1986
Pisum sativum
-
Manually annotated by BRENDA team
Ferte, N.; Jaquot, J.P.; Meunier, J.C.
Structural, immunological and kinetic comparisons of NADP-dependent malate dehydrogenases from spinach (C3) and corn (C4) chloroplasts
Eur. J. Biochem.
154
587-595
1986
Spinacia oleracea, Zea mays
Manually annotated by BRENDA team
Gotow, K.; Tanaka, K.; Kondo, N.; Kobayashi, K.; Syono, K.
Light activation of NADP-malate dehydrogenase in guard cell protoplasts from Vicia faba L.
Plant Physiol.
79
829-832
1985
Vicia faba
Manually annotated by BRENDA team
Ferte, N.; Meunier, J.C.
Purification of several NADP-dependent malate dehydrogenase isoenzymes from spinach leaves. Kinetic properties
Plant Sci. Lett.
37
115-121
1984
Spinacia oleracea
-
Manually annotated by BRENDA team
Wolosiuk, R.A.; Buchanan, B.B.; Crawford, N.A.
Regulation of NADP-malate dehydrogenase by light-actuated ferredoxin/thioredoxin system of chloroplasts
FEBS Lett.
81
253-258
1977
Spinacia oleracea
-
Manually annotated by BRENDA team
Scheibe, R.; Fickenscher, K.
The dark (oxidized) form of the light-activatable NADP-malate dehydrogenase from pea chloroplasts is catalytically active in the presence of guanidine-HCl
FEBS Lett.
180
317-320
1985
Pisum sativum
-
Manually annotated by BRENDA team
Perrot-Rechenmann, C.; Jacquot, J.P.; Gadal, P.; Weeden, N.F.; Cseke, C.; Buchanan, B.B.
Localization of NADP-malate dehydrogenase of corn leaves by immunological methods
Plant Sci. Lett.
30
219-226
1983
Zea mays
-
Manually annotated by BRENDA team
Scheibe, R.; Jacquot, J.P.
NADP regulates the light activation of NADP-dependent malate dehydrogenase
Planta
157
548-553
1983
Pisum sativum
Manually annotated by BRENDA team
Fickenscher, K.; Scheibe, R.
Purification and properties of NADP-dependent malate dehydrogenase from pea leaves
Biochim. Biophys. Acta
749
249-254
1983
Pisum sativum
-
Manually annotated by BRENDA team
Ferte, N.; Meunier, J.C.; Ricard, J.; Buc, J.; Sauve, P.
Molecular properties and thioredoxin-mediated activation of spinach chloroplastic NADP-malate dehydrogenase
FEBS Lett.
146
133-138
1982
Spinacia oleracea
-
Manually annotated by BRENDA team
Jacquot, J.P.P.; Buchanan, B.B.; Martin, F.; Vidal, J.
Enzyme regulation in C4 photosynthesis. Purification and properties of thioredoxin-linked NADP-malate dehydrogenase from corn leaves
Plant Physiol.
68
300-304
1981
Zea mays
Manually annotated by BRENDA team
Mohamed, A.H.; Anderson, L.E.
Extraction of chloroplast light effect mediator(s) and reconstitution of light activation of NADP-linked malate dehydrogenase
Arch. Biochem. Biophys.
209
606-612
1981
Pisum sativum
Manually annotated by BRENDA team
Cretin, C.; Luchetta, P.; Joly, C.; Decottignies, P.; Lepiniec, L.; Gadal, P.; Sallantin, M.; Huet, J.C.; Pernollet, J.C.
Primary structure of sorghum malate dehydrogenase (NADP) deduced from cDNA sequence. Homology with malate dehydrogenase (NAD)
Eur. J. Biochem.
192
299-303
1990
Sorghum bicolor
Manually annotated by BRENDA team
Johansson, K.; Ramaswamy, S.; Saarinen, M.; Lemaire-Chamley, M.; Issakidis-Bourguet, E.; Miginiac-Maslow, M.; Eklund, H.
Structural basis for light activation of a chloroplast enzyme: The structure of Sorghum NADP-malate dehydrogenase in its oxidized form
Biochemistry
38
4319-4326
1999
Sorghum bicolor (P17606), Sorghum bicolor
Manually annotated by BRENDA team
MacPherson, K.H.; Ashton, A.R.; Carr, P.D.; Trevanion, S.J.; Verger, D.; Ollis, D.L.
Crystallization and preliminary crystallographic studies of chloroplast NADP-dependent malate dehydrogenase from Flaveria bidentis
Acta Crystallogr. Sect. D
54
654-656
1998
Flaveria bidentis
Manually annotated by BRENDA team
Hatch, M.D.; Slack, C.R.
NADPH-specific malate dehydrogenase and glycerate kinase in leaves and evidence for their location in chloroplasts
Biochem. Biophys. Res. Commun.
34
589-593
1969
Amaranthus palmeri, Beta vulgaris, Daucus carota, Pisum sativum, Saccharum sp., Spinacia oleracea, Zea mays
Manually annotated by BRENDA team
Scheibe, R.; Geissler, A.; Rother, T.
Analysis of biophysical differences between oxidized and reduced chloroplast NADP-malate dehydrogenase
Arch. Biochem. Biophys.
300
635-640
1993
Pisum sativum, Spinacia oleracea
Manually annotated by BRENDA team
Kampfenkel, K.
Limited proteolysis of NADP-malate dehydrogenase from pea chloroplast by aminopeptidase K yields monomers. Evidence of proteolytic degradation of NADP-malate dehydrogenase during purification from pea
Biochim. Biophys. Acta
1156
71-77
1992
Pisum sativum
Manually annotated by BRENDA team
Riessland, R.; Jaenicke, R.
Determination of the regulatory disulfide bonds of NADP-dependent malate dehydrogenase from Pisum sativum by site-directed mutagenesis
Biol. Chem.
378
983-988
1997
Pisum sativum
Manually annotated by BRENDA team
Gupta, V.K.; Singh, R.
Properties of NADP+-malate dehydrogenase from immature pod wall of Cicer arietinum
Plant Physiol. Biochem.
28
671-678
1990
Cicer arietinum
-
Manually annotated by BRENDA team
Issakidis, E.; Miginiac-Maslow, M.; Decottignies, P.; Jacquot, J.P.; Cretin, C.; Gadal, P.
Site-directed mutagenesis reveals the involvement of an additional thioredoxin-dependent regulatory site in the activation of recombinant sorghum leaf NADP-malate dehydrogenase
J. Biol. Chem.
267
21577-21583
1992
Sorghum sp.
Manually annotated by BRENDA team
Ruelland, E.; Johansson, K.; Decottignies, P.; Djukic, N.; Miginiac-Maslow, M.
The autoinhibition of sorghum NADP malate dehydrogenase is mediated by a C-terminal negative charge
J. Biol. Chem.
273
33482-33488
1998
Sorghum sp.
Manually annotated by BRENDA team
Carr, P.D.; Verger, D.; Ashton, A.R.; Ollis, D.L.
Chloroplast NADP-malate dehydrogenase: structural basis of light-dependent regulation of activity by thiol oxidation and reduction
Structure
7
461-475
1999
Flaveria bidentis
Manually annotated by BRENDA team
Schepens, I.; Decottignies, P.; Ruelland, E.; Johansson, K.; Miginiac-Maslow, M.
The dimer contact area of sorghum NADP-malate dehydrogenase: role of aspartate 101 in dimer stability and catalytic activity
FEBS Lett.
471
240-244
2000
Sorghum sp.
Manually annotated by BRENDA team
Hirasawa, M.; Ruelland, E.; Schepens, I.; Issakidis-Bourguet, E.; Miginiac-Maslow, M.; Knaff, D.B.
Oxidation-reduction properties of the regulatory disulfides of sorghum chloroplast nicotinamide adenine dinucleotide phosphate-malate dehydrogenase
Biochemistry
39
3344-3350
2000
Sorghum bicolor, Sorghum sp.
Manually annotated by BRENDA team
Jacquot, J.P.; Keryer, E.; Issakidis, E.; Decottignies, P.; Miginiac-Maslow, M.; Schmitter, J.M.; Cretin, C.
Properties of recombinant NADP-malate dehydrogenases from Sorghum vulgare leaves expressed in Escherichia coli cells
Eur. J. Biochem.
199
47-51
1991
Sorghum bicolor
Manually annotated by BRENDA team
Braun, H.; Lichter, A.; Haberlein, I.
Kinetic evidence for protein complexes between thioredoxin and NADP-malate dehydrogenase and presence of a thioredoxin binding site at the N-terminus of the enzyme
Eur. J. Biochem.
240
781-788
1996
Glycine max
Manually annotated by BRENDA team
Lemaire, M.; Miginiac-Maslow, M.; Decottignies, P.
The catalytic site of chloroplastic NADP-dependent malate dehydrogenase contains a His/Asp pair
Eur. J. Biochem.
236
947-952
1996
Sorghum sp.
Manually annotated by BRENDA team
Gomez, I.; Merchan, F.; Fernandez, E.; Quesada, A.
NADP-malate dehydrogenase from Chlamydomonas: prediction of new structural determinants for redox regulation by homology modelling
Plant Mol. Biol.
48
211-221
2002
Chlamydomonas reinhardtii, Chlamydomonas reinhardtii (Q9FNS5)
Manually annotated by BRENDA team
Rondeau, P.; Rouch, C.; Besnard, G.
NADP-malate dehydrogenase gene evolution in Andropogoneae (Poaceae): gene duplication followed by sub-functionalization
Ann. Bot.
96
1307-1314
2005
Chrysopogon zizanioides (Q8H0J7), Chrysopogon zizanioides (Q8L5S9), Dichanthium aristatum (Q8H0R5), Flaveria trinervia (Q42737), Heteropogon contortus (Q2MG92), Hyparrhenia rufa (Q2MG94), Ischaemum koleostachys (Q8H0Q3), Megathyrsus maximus (Q8H0N9), Melinis repens (Q2MG93), Oplismenus compositus (Q8H0P4), Oryza sativa, Paspalidium geminatum (Q1RS11), Paspalum paniculatum (Q8H0N5), Pogonatherum paniceum (Q8H0N4), Saccharum hybrid cultivar R570 (Q4W4C2), Saccharum officinarum (Q1RS10), Saccharum officinarum (Q8L6C8), Saccharum spontaneum (Q8H0M0), Sorghum arundinaceum (Q8H0L7), Sorghum bicolor (P17606), Sorghum bicolor (P37229), Themeda quadrivalvis (Q8H0K0), Zea mays (P15719), Zea mays
Manually annotated by BRENDA team
Lemaire, S.D.; Quesada, A.; Merchan, F.; Corral, J.M.; Igeno, M.I.; Keryer, E.; Issakidis-Bourguet, E.; Hirasawa, M.; Knaff, D.B.; Miginiac-Maslow, M.
NADP-malate dehydrogenase from unicellular green alga Chlamydomonas reinhardtii. A first step toward redox regulation?
Plant Physiol.
137
514-521
2005
Chlamydomonas reinhardtii, Chlamydomonas reinhardtii (Q9FNS5)
Manually annotated by BRENDA team
Zhang, C.; Chen, L.; Shi, D.; Chen, G.; Lu, C.; Wang, P.; Wang, J.; Chu, H.; Zhou, Q.; Zuo, M.; Sun, L.
Characteristics of ribulose-1,5-bisphosphate carboxylase and C4 pathway key enzymes in flag leaves of a super-high-yield hybrid rice and its parents during the reproductive stage
S. Afr. J. Bot.
73
22-28
2007
Oryza sativa
-
Manually annotated by BRENDA team
Hameister, S.; Becker, B.; Holtgrefe, S.; Strodtkoetter, I.; Linke, V.; Backhausen, J.E.; Scheibe, R.
Transcriptional regulation of NADP-dependent malate dehydrogenase: comparative genetics and identification of DNA-binding proteins
J. Mol. Evol.
65
437-455
2007
Arabidopsis lyrata subsp. petraea, Arabidopsis thaliana, Capsella bursa-pastoris, Capsella rubella, Cochlearia officinalis, Lepidium densiflorum, Lepidium latifolium
Manually annotated by BRENDA team
Anderson, L.E.; Fadowole, D.; Reyes, B.A.; Carol, A.A.
Distribution of thioredoxins f and m with respect to seven light-activated enzymes and three redox-insensitive proteins in pea leaf chloroplasts
Plant Sci.
174
432-445
2008
Pisum sativum
Manually annotated by BRENDA team
Kawakami, R.; Sakuraba, H.; Goda, S.; Tsuge, H.; Ohshima, T.
Refolding, characterization and crystal structure of (S)-malate dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix
Biochim. Biophys. Acta
1794
1496-1504
2009
Aeropyrum pernix (Q9YEA1)
Manually annotated by BRENDA team
Libik-Konieczny, M.; Surowka, E.; Nosek, M.; Goraj, S.; Miszalski, Z.
Pathogen-induced changes in malate content and NADP-dependent malic enzyme activity in C3 or CAM performing Mesembryanthemum crystallinum L. plants
Acta Physiol. Plant.
34
1471-1477
2012
Mesembryanthemum crystallinum
-
Manually annotated by BRENDA team
Dulermo, T.; Lazar, Z.; Dulermo, R.; Rakicka, M.; Haddouche, R.; Nicaud, J.M.
Analysis of ATP-citrate lyase and malic enzyme mutants of Yarrowia lipolytica points out the importance of mannitol metabolism in fatty acid synthesis
Biochim. Biophys. Acta
1851
1107-1117
2015
no activity in Yarrowia lipolytica
Manually annotated by BRENDA team
Heyno, E.; Innocenti, G.; Lemaire, S.D.; Issakidis-Bourguet, E.; Krieger-Liszkay, A.
Putative role of the malate valve enzyme NADP-malate dehydrogenase in H2O2 signalling in Arabidopsis
Philos. Trans. R. Soc. Lond. B Biol. Sci.
369
20130228
2014
Arabidopsis thaliana, Arabidopsis thaliana (Q8H1E2)
Manually annotated by BRENDA team