1.1.1.82: malate dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about malate dehydrogenase (NADP+), go to the full flat file.

Reaction

(S)-malate
+
NADP+
=
oxaloacetate
+
NADPH
+
H+

Synonyms

(S)-malate dehydrogenase, dehydrogenase, malate (nicotinamide adenine dinucleotide phosphate), malate NADP dehydrogenase, malic dehydrogenase (nicotinamide adenine dinucleotide phosphate), MDH, NADP malate dehydrogenase, NADP-dependent malate dehydrogenase, NADP-linked malate dehydrogenase, NADP-malate dehydrogenase, NADP-malic enzyme, NADP-MDH, NADP-MDH1, NADP-MDH2, NADPH-MDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.82 malate dehydrogenase (NADP+)

Inhibitors

Inhibitors on EC 1.1.1.82 - malate dehydrogenase (NADP+)

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-oxoglutarate
-
5 mM
ATP
-
5 mM
citrate
-
5 mM
diethyldicarbonate
-
inactivation follows pseudo-first-order reaction kinetics, partial protection by NADP+, complete protection in presence of NADP+, 0.25 M hydroxylamine causes total reversal of inhibition
HgCl2
-
activity of the oxidized enzyme in presence of guanidine is unaffected by 0.1 mM HgCl2 in presence of 1 mM EDTA and by 0.005 mM HgCl2 in absence of EDTA, activity of the reduced form of enzyme is completely abolished
iodoacetamide
-
-
isocitrate
-
5 mM
KCl
-
oxidized truncated enzyme
malate
NADP+
NADPH
-
substrate inhibition
oxalate
-
5 mM
oxaloacetate
Urea
-
oxidized truncated enzyme
additional information
-