1.1.1.81: hydroxypyruvate reductase

This is an abbreviated version, for detailed information about hydroxypyruvate reductase, go to the full flat file.

Reaction

D-glycerate
+
NAD(P)+
=
Hydroxypyruvate
+
NAD(P)H
+
H+

Synonyms

At1g12550, AtHPR1, beta-hydroxypyruvate reductase, D-2-hydroxy-acid dehydrogenase, D-glycerate dehydrogenase, glyoxylate reductase/hydroxypyruvate reductase, glyoxylate/hydroxypyruvate reductase, GLYR1, GRHPR, HPR1, HPR2, HPR3, HRP, hydroxypyruvate reductase, More, NADH-dependent hydroxypyruvate reducing enzyme activity, NADH-dependent hydroxypyruvate reductase, NADH-HPR, NADH:hydroxypyruvate reductase, NADPH-dependent hydroxypyruvate reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.81 hydroxypyruvate reductase

Reference

Reference on EC 1.1.1.81 - hydroxypyruvate reductase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kleczkowski, L.A.; Randall, D.D.; Edwards, G.E.
Oxalate as a potent and selective inhibitor of spinach (Spinacia oleracea) leaf NADPH-dependent hydroxypyruvate reductase
Biochem. J.
276
125-127
1991
Spinacia oleracea
Manually annotated by BRENDA team
Chistoserdova, L.V.; Lidstrom, M.E.
Purification and characterization of hydroxypyruvate reductase from the facultative methylotroph Methylobacterium extorquens AM1
J. Bacteriol.
173
7228-7232
1991
Methylobacterium extorquens AM1
Manually annotated by BRENDA team
Hagishita, T.; Yoshida, T.; Izumi, Y.; Mitsunaga, T.
Immunological characterization of serine-glyoxylate aminotransferase and hydroxypyruvate reductase from a methylotrophic bacterium, Hyphomicrobium methylovorum GM2
FEMS Microbiol. Lett.
142
49-52
1996
Cucumis sativus, Hyphomicrobium methylovorum GM2, Methylobacterium extorquens AM1, Methylobacterium organophilum, Spinacia oleracea
Manually annotated by BRENDA team
Yoshida, T.; Yamaguchi, K.; Hagishata, T.; Miyata, T.; Tanabe, T.; Toh, H.; Oshiro, T.; Shimao, M.; Itumi, Y.
Cloning and expression of the gene for hydroxypyruvate reductase (D-glycerate dehydrogenase) from an obligate methylotroph Hyphomicrobium methyovorum GM2
Eur. J. Biochem.
223
727-732
1994
Hyphomicrobium methylovorum GM2
Manually annotated by BRENDA team
Oliver, M.J.; Ferguson, D.L.; Burke, J.J.; Velten, J.
Inhibition of tobacco NADH-hydroxypyruvate reductase by expression of a heterologous antisense RNA derived from a cucumber cDNA: implications for the mechanism of action of antisense RNAs
Mol. Gen. Genet.
239
425-434
1993
Nicotiana tabacum cv. SR1
Manually annotated by BRENDA team
Kleczkowski, L.A.; Edwards, G.E.; Blackwell, R.D.; Lea, P.J.; Givan, C.V.
Enzymology of the reduction of hydroxypyruvate and glyoxylate in a mutant of barley lacking peroxisomal hydroxypyruvate reductase
Plant Physiol.
94
819-825
1990
Hordeum vulgare
Manually annotated by BRENDA team
Krema, C.; Lidstrom, M.E.
Hydroxypyruvate reductase from Methylobacterium extorquens AM1
Methods Enzymol.
188
373-378
1990
Methylobacterium extorquens AM1
-
Manually annotated by BRENDA team
Kleczkowski, L.A.; Edwards, G.E.
Identification of hydroxypyruvate and glyoxylate reductase in maize leaves
Plant Physiol.
91
278-288
1989
Zea mays
Manually annotated by BRENDA team
Murray, A.J.S.; Blackwell, R.D.; Lea, P.J.
Metabolism of hydroxypyruvate in a mutant of barley lacking NADH-dependent hydroxypyruvate reductase, an important photorespiratory enzyme activity
Plant Physiol.
91
395-400
1989
Hordeum vulgare
Manually annotated by BRENDA team
Sautter, C.; Sautter, E.; Hock, B.
Import of peroxisomal hydroxypyruvate reductase into glyoxysomes
Planta
176
149-158
1988
Citrullus lanatus subsp. vulgaris, Cucurbita pepo, Spinacia oleracea
Manually annotated by BRENDA team
Kleczkowski, L.A.; Givan, C.V.; Hodgson, J.M.; Randall, D.D.
Subcellular location of NADPH-dependent hydroxypyruvate reductase activity in leaf protoplasts of Pisum sativum L. and its role in photorespiratory metabolism
Plant Physiol.
88
1182-1185
1988
Pisum sativum, Spinacia oleracea
Manually annotated by BRENDA team
Kleczkowski, L.A.; Randall, D.D.
Purification and characterization of a novel NADPH(NADH)-dependent hydroxypyruvate reductase from spinach leaves. Comparison of immunological properties of leaf hydroxypyruvate reductases
Biochem. J.
250
145-152
1988
Spinacia oleracea
Manually annotated by BRENDA team
Bamforth, C.W.; Quayle, J.R.
Hydroxypyruvate reductase activity in Paracoccus denitrificans
J. Gen. Microbiol.
101
259-267
1977
Paracoccus denitrificans
-
Manually annotated by BRENDA team
Feld, R.D.; Sallach, H.J.
Comparison of D-glycerate dehydrogenases from beef liver, beef spinal cord and hog spinal cord
Arch. Biochem. Biophys.
166
417-425
1975
Bos taurus, Sus scrofa
Manually annotated by BRENDA team
Feld, R.D.; Sallach, H.J.
D-Glycerate dehydrogenase from hog spinal cord
Methods Enzymol.
41B
289-293
1975
Sus scrofa
Manually annotated by BRENDA team
Sugimoto, E.; Kitagawa, Y.; Hirose, M.; Chiba, H.
Mechanisms of inhibition and activation of beef liver D-glycerate dehydrogenase by inorganic anions
J. Biochem.
72
1317-1325
1972
Bos taurus
Manually annotated by BRENDA team
Sugimoto, E.; Kitagawa, Y.; Nakanishi, K.; Chiba, H.
Purification and properties of beef liver D-glycerate dehydrogenase
J. Biochem.
72
1307-1315
1972
Bos taurus
Manually annotated by BRENDA team
Uhr, M.L.; Sneddon, M.K.
Glycine and serine inhibition of D-glycerate dehydrogenase and 3-phosphoglycerate dehydrogenase of rat brain
FEBS Lett.
17
137-140
1971
Rattus norvegicus
Manually annotated by BRENDA team
Kohn, L.D.; Jakoby, W.B.
Tartaric acid metabolism. VII. Crystalline hydroxypyruvate reductase (D-glycerate dehydrogenase)
J. Biol. Chem.
243
2494-2499
1968
Delftia acidovorans
Manually annotated by BRENDA team
Kohn, L.D.; Jakoby, W.B.
Hydroxypyruvate reductase (D-glycerate dehydrogenase; crystalline) Pseudomonas
Methods Enzymol.
9
229-232
1966
Delftia acidovorans
-
Manually annotated by BRENDA team
Coderch, R.; Lluis, C.; Bozal, J.
Effect of salts on D-glycerate dehydrogenase kinetic behavior
Biochim. Biophys. Acta
566
21-31
1979
Bos taurus
Manually annotated by BRENDA team
Booth, M.P.; Conners, R.; Rumsby, G.; Brady, R.L.
Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase
J. Mol. Biol.
360
178-189
2006
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Yoshikawa, S.; Arai, R.; Kinoshita, Y.; Uchikubo-Kamo, T.; Wakamatsu, T.; Akasaka, R.; Masui, R.; Terada, T.; Kuramitsu, S.; Shirouzu, M.; Yokoyama, S.
Structure of archaeal glyoxylate reductase from Pyrococcus horikoshii OT3 complexed with nicotinamide adenine dinucleotide phosphate
Acta Crystallogr. Sect. D
63
357-365
2007
Pyrococcus horikoshii OT3
Manually annotated by BRENDA team
Shen, P.H.; Wu, B.
Over-expression of a hydroxypyruvate reductase in Methylobacterium sp. MB200 enhances glyoxylate accumulation
J. Ind. Microbiol. Biotechnol.
34
657-663
2007
Methylobacterium sp., Methylobacterium sp. MB200
Manually annotated by BRENDA team
Piotrowska, A.; Czerpak, R.
Cellular response of light/dark-grown green alga Chlorella vulgaris Beijerinck (Chlorophyceae) to exogenous adenine- and phenylurea-type cytokinins
Acta Physiol. Plant.
31
573-585
2009
Chlorella vulgaris
-
Manually annotated by BRENDA team
Timm, S.; Nunes-Nesi, A.; Paernik, T.; Morgenthal, K.; Wienkoop, S.; Keerberg, O.; Weckwerth, W.; Kleczkowski, L.A.; Fernie, A.R.; Bauwe, H.
A cytosolic pathway for the conversion of hydroxypyruvate to glycerate during photorespiration in Arabidopsis
Plant Cell
20
2848-2859
2008
Arabidopsis thaliana, Arabidopsis thaliana (Q9C9W5), Arabidopsis thaliana (Q9CA90)
Manually annotated by BRENDA team
Wang, Y.; Beaith, M.; Chalifoux, M.; Ying, J.; Uchacz, T.; Sarvas, C.; Griffiths, R.; Kuzma, M.; Wan, J.; Huang, Y.
Shoot-specific down-regulation of protein farnesyltransferase (alpha-subunit) for yield protection against drought in canola
Mol. Plant
2
191-200
2009
Brassica napus
Manually annotated by BRENDA team
Timm, S.; Florian, A.; Jahnke, K.; Nunes-Nesi, A.; Fernie, A.R.; Bauwe, H.
The hydroxypyruvate-reducing system in Arabidopsis: multiple enzymes for the same end
Plant Physiol.
155
694-705
2011
Arabidopsis thaliana (Q9LE33)
Manually annotated by BRENDA team
Hoover, G.J.; Jorgensen, R.; Rochon, A.; Bajwa, V.S.; Merrill, A.R.; Shelp, B.J.
Identification of catalytically important amino acid residues for enzymatic reduction of glyoxylate in plants
Biochim. Biophys. Acta
1834
2663-2671
2013
Arabidopsis thaliana (A0A1I9LPQ6), Arabidopsis thaliana (Q9C9W5), Arabidopsis thaliana (Q9CA90), Arabidopsis thaliana (Q9LE33)
Manually annotated by BRENDA team
Zong, C.; Nie, X.; Zhang, D.; Ji, Q.; Qin, Y.; Wang, L.; Jiang, D.; Gong, C.; Liu, Y.; Zhou, G.
Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis
Pathol. Res. Pract.
212
365-371
2016
Homo sapiens (Q9UBQ7)
Manually annotated by BRENDA team
Lassalle, L.; Engilberge, S.; Madern, D.; Vauclare, P.; Franzetti, B.; Girard, E.
New insights into the mechanism of substrates trafficking in glyoxylate/hydroxypyruvate reductases
Sci. Rep.
6
20629
2016
Pyrococcus furiosus (Q8U3Y2), Pyrococcus horikoshii, Pyrococcus yayanosii (F8AEA4), Pyrococcus yayanosii CH1 (F8AEA4)
Manually annotated by BRENDA team