1.1.1.81: hydroxypyruvate reductase

This is an abbreviated version, for detailed information about hydroxypyruvate reductase, go to the full flat file.

Reaction

D-glycerate
+
NAD(P)+
=
Hydroxypyruvate
+
NAD(P)H
+
H+

Synonyms

At1g12550, AtHPR1, beta-hydroxypyruvate reductase, D-2-hydroxy-acid dehydrogenase, D-glycerate dehydrogenase, glyoxylate reductase/hydroxypyruvate reductase, glyoxylate/hydroxypyruvate reductase, GLYR1, GRHPR, HPR1, HPR2, HPR3, HRP, hydroxypyruvate reductase, More, NADH-dependent hydroxypyruvate reducing enzyme activity, NADH-dependent hydroxypyruvate reductase, NADH-HPR, NADH:hydroxypyruvate reductase, NADPH-dependent hydroxypyruvate reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.81 hydroxypyruvate reductase

Inhibitors

Inhibitors on EC 1.1.1.81 - hydroxypyruvate reductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,3-diphospho-D-glycerate
-
1 mM, 83% and 91% inhibition of hydroxypyruvate reduction and D-glycerate oxidation respectively
2-phospho-DL-glycerate
-
1 mM, 93% and 81% inhibition of hydroxypyruvate reduction and D-glycerate oxidation respectively
3-phospho-D-glycerate
-
1 mM, 53% and 65% inhibition of hydroxypyruvate reduction and D-glycerate oxidation respectively
Ag+
-
0.1 mM, complete inhibition
alpha-D-fructose 1,6-diphosphate
-
0.1 mM, 28% and 74% inhibition of hydroxypyruvate reduction and D-glycerate oxidation respectively
ATP
-
1 mM, 62% and 64% inhibition of liver and spinal cord enzyme respectively, 73% and 89% inhibition of hydroxypyruvate reduction and D-glycerate oxidation respectively
bromide
citrate
Cl-
-
100 mM, 50% inhibition of D-glycerate oxidation
CTP
-
1 mM, 73% and 71% inhibition of liver and spinal cord enzyme respectively
D-glycerate
glycolate
-
5 mM, 15% of NADPH linked reduction
glyoxylate
-
10 mM, 55% inhibition of NADH linked hydroxypyruvate reduction, 15% of NADPH linked reduction, 80% of NAD+ linked glycerate oxidation
GTP
-
1 mM, 94% and 93% inhibition of liver and spinal cord enzyme respectively
Hg2+
-
0.1 mM, complete inhibition
Hydroxypyruvate
Iodide
NAD+
-
4 mM, 10% inhibition of NADH linked hydroxypyruvate reduction, 60% of NADPH linked reduction
NADP+
-
4 mM, 15% inhibition of NADH linked hydroxypyruvate reduction, 40% of NADPH linked reduction, 8% of NAD+ linked glycerate oxidation
NaNO3
-
80 mM, 50% inhibition
NO3-
-
100 mM, 87% inhibition of D-glycerate oxidation
oxalate
oxaloacetate
-
2.5 mM, 10% inhibition of NADH linked hydroxypyruvate reduction, 20% of NADPH linked reduction
p-chloromercuribenzoate
-
0.1 mM, complete inhibition
phosphohydroxypyruvate
pyruvate
SO42-
-
100 mM, 55% inhibition of D-glycerate oxidation
Sodium bisulfite
-
0.01 mM, 16% inhibition, 0.1 mM, 67% inhibition
Tartronate
UTP
-
1 mM, 83% and 84% inhibition of liver and spinal cord enzyme respectively
additional information
-
not inhibited by 2 mM acetohydroxamate
-