1.1.1.79: glyoxylate reductase (NADP+)

This is an abbreviated version, for detailed information about glyoxylate reductase (NADP+), go to the full flat file.

Reaction

glycolate
+
NADP+
=
glyoxylate
+
NADPH
+
H+

Synonyms

AtGR1, AtGR2, D-2-hydroxy-acid dehydrogenase, glyoxylate reductase, glyoxylate reductase 1, glyoxylate reductase 2, glyoxylate reductase isoform 1, glyoxylate reductase/hydroxypyruvate reductase, GLYR1, GLYR2, GOR1, GR/HPR, GR1, GR2, GRHPR, GRHRP, More, TthGR1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.79 glyoxylate reductase (NADP+)

Inhibitors

Inhibitors on EC 1.1.1.79 - glyoxylate reductase (NADP+)

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
4-hydroxybutyrate
mixed type inhibition with NADPH; mixed type inhibition with succinic semialdehyde
adenine
-
0.01 mM, 70% inhibition after preincubation for 5 min
alpha-ketoglutarate
-
5 mM, 57% inhibition
Carbonate
-
20 mM, 7-16% inhibition
chloride
-
20 mM, 7-16% inhibition
cyanide
-
2 mM, 46% inhibition, 20 mM, 92% inhibition
cysteine
-
isoenzyme 1, 1 mM, 29% inhibition
D-glycerate
-
the enzyme shows product inhibition
diethyldicarbonate
-
1 mM, 33% inhibition, incubation for 1 min
dithiothreitol
glutathione
-
isoenzyme 1, 1 mM, 12% inhibition
glycidate
-
10 mM, 35% inhibition after 15 min
glycolate
iodoacetamide
iodoacetate
-
isoenzyme 2, 1 mM, 97% inhibition, isoenzyme 1, 1 mM, 18% inhibition
N-ethylmaleimide
NaCl
-
complete inhibition at 0.5 M
NADP+
nitrate
nitrite
-
20 mM, 7-16% inhibition
p-chloromercuribenzoate
PMSF
-
1 mM, 30% inhibition, incubation for 1 min
pyruvate
-
5 mM, 33% inhibition
Sodium fluoride
-
isoenzyme 1, 10 mM, 32% inhibition
sodium iodide
-
isoenzyme 1, 50 mM, 37% inhibition of glyoxylate reduction
Sodium phosphate
-
50% inhibition at 900 mM
additional information
-