1.1.1.77: lactaldehyde reductase

This is an abbreviated version, for detailed information about lactaldehyde reductase, go to the full flat file.

Reaction

(R)[or (S)]-propane-1,2-diol
+
NAD+
=
(R)[or (S)]-lactaldehyde
+
NADH
+
H+

Synonyms

L-lactaldehyde:propanediol oxidoreductase, Propanediol oxidoreductase, propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.77 lactaldehyde reductase

Inhibitors

Inhibitors on EC 1.1.1.77 - lactaldehyde reductase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ascorbate
-
0.025 mM FeCl3 and 0.035 mM ascorbate causes a 90% enzyme inactivation after 120 min = inactivation of metal-catalyzed oxidation; several amino-acids prevent the inactivation; under aerobic conditions 0.025 mM FeCl3 causes a 50% enzyme inactivation after 120 min
Fe2+
-
under anaerobic conditions 0.01 mM Fe2+ and 0.1 mM H2O2 had the effect of 85% enzyme inactivation after 2 min, with addition of 0.0001 mM catalase the inactivation is only 25% after 2 min and with addition of 0.01 mM superoxide dismutase instead of catalse the inactivation is again 82% after 2 min
Fe3+
-
0.025 mM FeCl3 and 0.035 mM ascorbate causes a 90% enzyme inactivation after 120 min = inactivation of metal-catalyzed oxidation; several amino-acids prevent the inactivation; under aerobic conditions 0.025 mM FeCl3 causes a 50% enzyme inactivation after 120 min
H2O2
-
under anaerobic conditions 0.01 mM Fe2+ and 0.1 mM H2O2 had the effect of 85% enzyme inactivation after 2 min, with addition of 0.0001 mM catalase the inactivation is only 25% after 2 min and with addition of 0.01 mM superoxide dismutase instead of catalse the inactivation is again 82% after 2 min
iodoacetate
-
-
L-1,2-propanediol
-
above 25 mM: substrate inhibition
N-ethylmaleimide
-
-
p-chloromercuribenzoate
-
-