1.1.1.76: (S,S)-butanediol dehydrogenase

This is an abbreviated version, for detailed information about (S,S)-butanediol dehydrogenase, go to the full flat file.

Reaction

(2S,3S)-butane-2,3-diol
+
NAD+
=
(S)-acetoin
+
NADH
+
H+

Synonyms

(2S, 3S)-BDH, (2S, 3S)-butanediol dehydrogenase, (S,S)-2,3-butanediol dehydrogenase, (S,S)-butanediol dehydrogenase, 2,3-BDH, 2,3-butanediol dehydrogenase, acetoin(diacetyl) reductase, AdR, ADS1, ARA1, BDH, budC, ButA, L(+)-2,3-butanediol dehydrogenase (L-acetoin forming), L-(2S,3S)-butanediol dehydrogenase, L-BDH, L-butanediol dehydrogenase, LBDH, meso-2,3-butanediol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.76 (S,S)-butanediol dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.76 - (S,S)-butanediol dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2S)-acetoin + NADH + H+
(2S,3S)-butane-2,3-diol + NAD+
show the reaction diagram
(2S,3S)-2,3-butanediol + NAD+
(3S)-acetoin + NADH + H+
show the reaction diagram
-
-
-
?
(2S,3S)-2,3-butanediol + NAD+
(R,S)-acetoin + NADH + H+
show the reaction diagram
-
selective catalysis of S,S- and meso-butanediol, but not R,R-butanediol
-
r
(2S,3S)-butane-2,3-diol + NAD+
(2S)-acetoin + NADH + H+
show the reaction diagram
(2S,3S)-butane-2,3-diol + NAD+
(S)-acetoin + NADH + H+
show the reaction diagram
(R,R)-butane-2,3-diol + NAD+
?
show the reaction diagram
-
-
-
-
?
(R,S)-acetoin + NADH + H+
(2S,3S)-2,3-butanediol + meso-2,3-butanediol + NAD+
show the reaction diagram
-
-
-
r
(R,S)-acetoin + NADPH
(2S,3S)-2,3-butanediol + meso-2,3-butanediol + NADP+
show the reaction diagram
-
-
Ara1p is selective toward the acetoin carbonyl group, leading to an S-alcohol
-
r
(S)-1-phenylethanol + NAD+
acetophenone + NADH + H+
show the reaction diagram
-
-
-
r
(S,S)-butane-2,3-diol + NAD+
L-acetoin + NADH + H+
show the reaction diagram
1,2-propanediol + NAD+
?
show the reaction diagram
-
0.57% activity compared to (2S,3S)-butane-2,3-diol
-
-
?
1,2-propanediol + NAD+
? + NADH + H+
show the reaction diagram
-
-
-
?
1,3-dihydroxyacetone + NADH + H+
?
show the reaction diagram
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
1-phenylpropanol + NAD+
1-phenylpropanal + NADH + H+
show the reaction diagram
-
-
-
?
2,2,2-trifluoroacetophenone + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
?
2,3-hexanedione + NADH + H+
?
show the reaction diagram
-
66% activity compared to diacetyl
-
-
?
2,3-pentanedione + NADH + H+
?
show the reaction diagram
2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
2-pentanol + NAD+
2-pentanone + NADH + H+
show the reaction diagram
3,4-hexanedione + NADH + H+
?
show the reaction diagram
-
10% activity compared to diacetyl
-
-
?
cyclohexanol + NAD+
cyclohexanone + NADH + H+
show the reaction diagram
diacetyl + NADH
L-acetoin + NAD+
show the reaction diagram
diacetyl + NADH + H+
(2S)-acetoin + NAD+
show the reaction diagram
diacetyl + NADH + H+
?
show the reaction diagram
-
35% activity in comparison to L-acetoin
-
-
r
ethyl pyruvate + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
?
glyceraldehyde + NADH + H+
?
show the reaction diagram
isopropanol + NAD+
isopropanal + NADH + H+
show the reaction diagram
-
-
-
?
L-acetoin + NADH
L-2,3-butanediol
show the reaction diagram
L-acetoin + NADH + H+
(S,S)-butane-2,3-diol + NAD+
show the reaction diagram
-
100% activity
-
-
r
L-acetoin + NADH + H+
(S,S)-butanediol + NAD+
show the reaction diagram
meso-2,3-butanediol + NAD+
(R,S)-acetoin + NADH + H+
show the reaction diagram
-
selective catalysis of S,S- and meso-butanediol, but not R,R-butanediol
-
r
meso-2,3-butanediol + NAD+
acetoin + NADH
show the reaction diagram
poor substrate
-
-
?
additional information
?
-