1.1.1.64: testosterone 17beta-dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about testosterone 17beta-dehydrogenase (NADP+), go to the full flat file.

Reaction

testosterone
+
NADP+
=
androstenedione
+
NADPH
+
H+

Synonyms

17-ketoreductase, 17beta-HSD, 17beta-HSD 3, 17beta-HSD type 3, 17beta-HSD type 5, 17beta-HSD-3, 17beta-HSD1, 17beta-HSD3, 17beta-HSD4, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 3, 17beta-hydroxysteroid dehydrogenase type 3, 17beta-hydroxysteroid dehydrogenase type 5, 17beta-hydroxysteroid dehydrogenases type 3, 17betaHSD3, 3beta-hydroxysteroid dehydrogenase type 3, AKR1C3, More, NADP-dependent testosterone-17beta-oxidoreductase, type 3 17beta-HSD, type 3 17beta-hydroxysteroid dehydrogenase, type 5 beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.64 testosterone 17beta-dehydrogenase (NADP+)

pH Optimum

pH Optimum on EC 1.1.1.64 - testosterone 17beta-dehydrogenase (NADP+)

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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.8
-
addition of testosterone shifts optimal pH to 7.4-7.8
6.1
-
reduction of androst-4-ene-3,17-dione
6.5
-
assay at
6.5 - 7.5
-
at 37C
8.5
-
at 50C
10
-
sharp drop of activity above
10.2
-
oxidation of benzene dihydrodiol, isoenzyme 2
10.6
-
oxidation of testosterone
10.8
-
oxidation of benzene dihydrodiol, isoenzyme 1