1.1.1.64: testosterone 17beta-dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about testosterone 17beta-dehydrogenase (NADP+), go to the full flat file.

Reaction

testosterone
+
NADP+
=
androstenedione
+
NADPH
+
H+

Synonyms

17-ketoreductase, 17beta-HSD, 17beta-HSD 3, 17beta-HSD type 3, 17beta-HSD type 5, 17beta-HSD-3, 17beta-HSD1, 17beta-HSD3, 17beta-HSD4, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 3, 17beta-hydroxysteroid dehydrogenase type 3, 17beta-hydroxysteroid dehydrogenase type 5, 17beta-hydroxysteroid dehydrogenases type 3, 17betaHSD3, 3beta-hydroxysteroid dehydrogenase type 3, AKR1C3, More, NADP-dependent testosterone-17beta-oxidoreductase, type 3 17beta-HSD, type 3 17beta-hydroxysteroid dehydrogenase, type 5 beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.64 testosterone 17beta-dehydrogenase (NADP+)

Substrates Products

Substrates Products on EC 1.1.1.64 - testosterone 17beta-dehydrogenase (NADP+)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-alpha-tetralol + NADP+
alpha-tetralone + NADPH + H+
show the reaction diagram
-
-
-
-
?
(S)-tetralol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
?
1,2,3,4-tetrahydro-1-naphthol + NADP+
1,2,3,4-tetrahydro-1-naphthone + NADPH
show the reaction diagram
-
isoenzymes 1 and 2
-
r
1-acenaphthenol + NADP+
1-acenaphthenone + NADPH
show the reaction diagram
-
isoenzymes 1 and 2
-
r
11-hydroxy-androstenedione + NADPH
11beta-hydroxy-testosterone
show the reaction diagram
11-ketoandrostenedione + NADPH
11-ketotestosterone + NADP+
show the reaction diagram
17beta-estradiol + NADP+
estrone + NADPH
show the reaction diagram
19-nortestosterone + NADP+
19-norandrostenedione + NADPH
show the reaction diagram
-
93% activity compared to testosterone oxidation
-
r
4-oxo-2-nonenal + NADPH + H+
4-hydroxy-2-nonenal + NADP+
show the reaction diagram
-
-
-
-
?
5alpha-androstane-17beta-ol-3-one + NADP+
5alpha-androstane-3,17-dione + NADPH
show the reaction diagram
-
30% activity compared to testosterone oxidation
-
r
5alpha-androstane-3alpha,17beta-diol + NADP+
5alpha-androstane-3alpha-ol-17-one + NADPH
show the reaction diagram
5alpha-androstane-3beta,17beta-diol + NADP+
5alpha-androstane-3beta-ol-17-one + NADPH
show the reaction diagram
5alpha-dihydrotestosterone + NADP+
5alpha-17-oxo-dihydrotestosterone + NADPH
show the reaction diagram
-
isoenzymes 1 and 2
-
r
5beta-androstane-17beta-ol + NADP+
5alpha-androstane-17-one + NADPH
show the reaction diagram
-
117% activity compared to testosterone oxidation
-
r
5beta-androstane-17beta-ol-3-one + NADP+
5beta-androstane-3,17-dione + NADPH
show the reaction diagram
-
330% activity compared to testosterone oxidation
-
r
5beta-androstane-3alpha,17beta-diol + NADP+
5alpha-androstane-3alpha-ol-17-one + NADPH
show the reaction diagram
-
1180% activity compared to testosterone oxidation
-
r
5beta-androstane-3alpha,17beta-diol + NADP+
5beta-androstane-3alpha-17-one + NADPH
show the reaction diagram
-
-
-
r
5beta-androstane-3alpha,17beta-diol + NADP+
5beta-androstane-3alpha-ol-17-one + NADPH
show the reaction diagram
-
-
-
r
5beta-dihydrotestosterone + NADP+
5beta-17-oxo-dihydrotestosterone + NADPH
show the reaction diagram
9,10-phenanthrenequinone + NADPH
?
show the reaction diagram
-
-
-
-
?
androst-4-ene-3,17-dione + NADPH
testosterone + NADP+
show the reaction diagram
androst-4-ene-3,17-dione + NADPH + H+
testosterone + NADP+
show the reaction diagram
-
-
-
-
?
androstanedione + NADPH
dihydrotestosterone + NADP+
show the reaction diagram
-
-
-
-
?
androstenedione + NADPH + H+
testosterone + NADP+
show the reaction diagram
androsterone + NADPH
androstane-3beta,17beta-diol + NADP+
show the reaction diagram
-
-
-
-
?
benzene dihydrodiol + NADP+
o-benzoquinone + NADPH
show the reaction diagram
-
isoenzymes 1 and 2
-
r
cyclohex-2-en-1-ol + NADP+
cyclohex-2-en-1-one + NADPH
show the reaction diagram
-
isoenzymes 1 and 2
-
r
dehydroepiandrosterone + NADPH
androst-5-en-3beta,17beta-diol + NADP+
show the reaction diagram
dehydroepiandrosterone + NADPH
androst-5-ene-3beta,17beta-diol + NADP+
show the reaction diagram
-
-
-
r
epiandrosterone + NADPH
androstane-3beta,17beta-diol + NADP+
show the reaction diagram
indan-1-ol + NADP+
indan-1-one + NADPH
show the reaction diagram
-
isoenzymes 1 and 2
-
r
pyridine-4-aldehyde + NADPH
pyridine-4-alcohol + NADP+
show the reaction diagram
-
isoenzymes 1 and 2
-
r
testosterone + NAD+
androst-4-ene-3,17-dione + NADH + H+
show the reaction diagram
testosterone + NAD+
androstenedione + NADH
show the reaction diagram
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
show the reaction diagram
additional information
?
-
-
human 17beta-hydroxysteroid dehydrogenases are multifunctional enzymes, isozyme 17beta-HSD4 also performs beta-oxidation of branched fatty acids, like pristanic acid, and in bile acid synthesis, e.g. of di- and trihydroxycholestanoic acids, overview
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