1.1.1.64: testosterone 17beta-dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about testosterone 17beta-dehydrogenase (NADP+), go to the full flat file.

Reaction

testosterone
+
NADP+
=
androstenedione
+
NADPH
+
H+

Synonyms

17-ketoreductase, 17beta-HSD, 17beta-HSD 3, 17beta-HSD type 3, 17beta-HSD type 5, 17beta-HSD-3, 17beta-HSD1, 17beta-HSD3, 17beta-HSD4, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 3, 17beta-hydroxysteroid dehydrogenase type 3, 17beta-hydroxysteroid dehydrogenase type 5, 17beta-hydroxysteroid dehydrogenases type 3, 17betaHSD3, 3beta-hydroxysteroid dehydrogenase type 3, AKR1C3, More, NADP-dependent testosterone-17beta-oxidoreductase, type 3 17beta-HSD, type 3 17beta-hydroxysteroid dehydrogenase, type 5 beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.64 testosterone 17beta-dehydrogenase (NADP+)

KM Value

KM Value on EC 1.1.1.64 - testosterone 17beta-dehydrogenase (NADP+)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.077
17beta-hydroxy-5alpha-androstane-3-one
-
-
0.0067
17beta-hydroxy-5beta-androstane-3-one
-
-
0.053
19-nortestosterone
-
-
0.0031
4-oxo-2-nonenal
-
pH 7.4, 25C
0.023
5alpha-androstane-3alpha,17beta-diol
-
-
0.011
5beta-androstane-3alpha,17beta-diol
-
-
0.029
5beta-androstane-3beta,17beta-diol
-
-
0.0007 - 0.04
androstenedione
0.47 - 6.7
benzene dihydrodiol
0.0033
estrone
-
-
0.1012
NAD+
-
-
0.177
NADH
-
-
0.0046 - 0.047
NADP+
0.0083 - 0.011
NADPH
0.0015 - 0.27
testosterone
additional information
additional information
-