1.1.1.64: testosterone 17beta-dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about testosterone 17beta-dehydrogenase (NADP+), go to the full flat file.

Reaction

testosterone
+
NADP+
=
androstenedione
+
NADPH
+
H+

Synonyms

17-ketoreductase, 17beta-HSD, 17beta-HSD 3, 17beta-HSD type 3, 17beta-HSD type 5, 17beta-HSD-3, 17beta-HSD1, 17beta-HSD3, 17beta-HSD4, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 3, 17beta-hydroxysteroid dehydrogenase type 3, 17beta-hydroxysteroid dehydrogenase type 5, 17beta-hydroxysteroid dehydrogenases type 3, 17betaHSD3, 3beta-hydroxysteroid dehydrogenase type 3, AKR1C3, More, NADP-dependent testosterone-17beta-oxidoreductase, type 3 17beta-HSD, type 3 17beta-hydroxysteroid dehydrogenase, type 5 beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.64 testosterone 17beta-dehydrogenase (NADP+)

IC50 Value

IC50 Value on EC 1.1.1.64 - testosterone 17beta-dehydrogenase (NADP+)

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00113 - 0.01093
(+)-gossypol
0.00036 - 0.00343
(-)-gossypol
0.0136
(2E)-3-(4-bromophenyl)-2-[4-(methylsulfonyl)phenyl]prop-2-enoic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0136
(2E)-3-(4-ethylphenyl)-2-[4-(methylsulfonyl)phenyl]prop-2-enoic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0134
(2E)-3-(4-methylphenyl)-2-[4-(methylsulfonyl)phenyl]prop-2-enoic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0058
(2E)-3-[4-(methylsulfanyl)phenyl]-2-[4-(methylsulfonyl)phenyl]prop-2-enoic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000006
(3alpha,5alpha)-3-[[trans-2,5-dimethyl-4-[[2-(trifluoromethyl)-phenyl]sulfonyl]piperazin-1-yl]methyl]-3-hydroxyandrostan-17-one
Homo sapiens
-
assay uses homogenized cells, pH not specified in the publication, temperature not specified in the publication
0.00008
(3R,10S,13S)-3-(Adamantan-1-ylmethyl-butyl-amino)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one
Homo sapiens
-
IC50: 80 nM
0.000074
(3R,10S,13S)-3-[(2-Cyclopentyl-ethyl)-morpholin-4-yl-amino]-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one
Homo sapiens
-
IC50: 74 nM
0.0091 - 0.00915
(RS)-3(2,3,3-triphenyl-prop-2-enoxycarbonyl)-3(prop-2-ynyl)pyrrolidine-2,5-dione
0.0421
(RS)-3(3'-phenylpropoxycarbonyl)-3(prop-2-ynyl)pyrrolidine-2,5-dione
Homo sapiens
-
IC50: 0.0421 mM
0.08951
1-(4-hydroxyphenyl)-butan-1-one
Rattus norvegicus
-
IC50: 0.08951 mM
1.70892
1-(4-hydroxyphenyl)-ethanone
Rattus norvegicus
-
IC50: 1.70892 mM
0.0784
1-(4-hydroxyphenyl)-heptan-1-one
Rattus norvegicus
-
IC50: 0.0784 mM
0.01802
1-(4-hydroxyphenyl)-hexan-1-one
Rattus norvegicus
-
IC50: 0.01802 mM
0.00286
1-(4-hydroxyphenyl)-nonan-1-one
Rattus norvegicus
-
IC50: 0.00286 mM
0.00652
1-(4-hydroxyphenyl)-octan-1-one
Rattus norvegicus
-
IC50: 0.00652 mM
0.00497 - 0.06052
1-(4-hydroxyphenyl)-pentan-1-one
0.15056
1-(4-hydroxyphenyl)-propan-1-one
Rattus norvegicus
-
IC50: 0.15056 mM
0.00755
1-(4-hydroxyphenyl)-undeca-1-one
Rattus norvegicus
-
IC50: 0.00755 mM
0.000094
1-(4-[[(2R)-2-methylpiperidin-1-yl]sulfonyl]phenyl)-1,3-dihydro-2H-pyrrol-2-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000056
1-(4-[[(2R,6S)-2,6-dimethylpiperidin-1-yl]sulfonyl]phenyl)pyrrolidin-2-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000052
1-[4-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]pyrrolidin-2-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0027
2,5-diphenyl-p-benzoquinone
Homo sapiens
-
IC50: 0.0027 mM, reduction of androstenedione
0.000213
2-(2,4-dioxo-1,3-thiazolidin-5-yl)-N-(2-hydroxyphenyl)acetamide
Homo sapiens
-
pH 7.0, temperature not specified in the publication
0.0064
2-methylcinnamic acid
Homo sapiens
-
IC50: 0.0064 mM
0.0052
2-[[(3-hydroxyphenyl)carbonyl]amino]-4,5-dimethoxybenzoic acid
Homo sapiens
-
pH 7.0, temperature not specified in the publication
0.00084
2-[[(3-hydroxyphenyl)carbonyl]amino]-5-nitrobenzoic acid
Homo sapiens
-
pH 7.0, temperature not specified in the publication
0.049
3,4,5-trimethoxycinnamic acid
Homo sapiens
-
IC50: 0.049 mM
0.08
3-((4-nitronaphthalen-1-yl)amino)benzoic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0083
3-(4-Bromo-2-methyl-benzyl)-7-hydroxy-chroman-4-one
Homo sapiens
-
IC50: 0.0083 mM, reduction of androstenedione
0.0018
3-(4-Chloro-2-methyl-benzyl)-7-hydroxy-chroman-4-one
Homo sapiens
-
IC50: 0.0018 mM, reduction of androstenedione
0.007
3-(4-Fluoro-2-methyl-benzyl)-7-hydroxy-chroman-4-one
Homo sapiens
-
IC50: 0.007 mM, reduction of androstenedione
0.1
3-cyclohexylpropanoic acid
Homo sapiens
-
weak inhibition, IC50: 0.1 mM, above
0.043
3-trifluoromethylcinnamic acid
Homo sapiens
-
IC50: 0.043 mM
0.000036
3-[(4-nitrophenyl)amino]benzoic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000054
3-[[4-(methoxymethyl)phenyl]amino]benzoic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000062
3-[[4-(trifluoromethyl)phenyl]amino]benzoic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00546
3a-phenyl-2,3,3a,4-tetrahydro-1H-pyrrolo[1,2-a]benzimidazol-1-one
Homo sapiens
-
pH 7.0, temperature not specified in the publication
0.000352
3alpha-ethoxy-3beta-(phenylmethyl)-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 92% inhibition, IC50: 352 nM
0.000081
3alpha-hydroxy-3'-phenyl-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 95% inhibition, IC50: 81 nM
0.000147
3alpha-hydroxy-3beta-octyl-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 92% inhibition, IC50: 147 nM
0.000099
3alpha-hydroxy-3beta-phenylethyl-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 93% inhibition, IC50: 99 nM
0.000057
3alpha-hydroxy-3beta-phenylmethyl-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 94% inhibition, IC50: 57 nM
0.000067
3alpha-hydroxy-3beta-propyl-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 94% inhibition, IC50: 67 nM
0.000073
3alpha-methoxy-3beta-(2'-phenylethyl)-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 95% inhibition, IC50: 73 nM
0.000154
3alpha-methoxy-3beta-(phenylmethyl)-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 93% inhibition, IC50: 154 nM
0.000354
3beta-(2'-cyclohexylethyl)-3alpha-methoxy-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 88% inhibition, IC50: 354 nM
0.000097
3beta-cyclohexyl-3alpha-hydroxy-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 95% inhibition, IC50: 97 nM
0.00006
3beta-cyclohexylethyl-3alpha-hydroxy-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 93% inhibition, IC50: 60 nM
0.00006
3beta-cyclohexylethyl-androsterone
Homo sapiens
-
IC50: 60 nM
0.000087
3beta-cyclohexylmethyl-3alpha-hydroxy-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 95% inhibition, IC50: 87 nM
0.000116
3beta-n-butyl-3alpha-hydroxy-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 92% inhibition, IC50: 116 nM
0.0001
3beta-n-hexyl-3alpha-hydroxy-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 95% inhibition, IC50: 100 nM
0.000057
3beta-phenylmethyl-androsterone
Homo sapiens
-
IC50: 57 nM
0.000067
3beta-propyl-androsterone
Homo sapiens
-
IC50: 67 nM
0.000073
3beta-s-butyl-3alpha-hydroxy-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 90% inhibition, IC50: 73 nM
0.000073
3beta-sec-butyl-androsterone
Homo sapiens
-
IC50: 73 nM
0.000142
3beta-tert-butyl-3alpha-hydroxy-5alpha-androstan-17-one
Homo sapiens
-
0.003 mM, 93% inhibition, IC50: 142 nM
0.0009 - 0.0019
4-Methylumbelliferone
0.000002
5-(3-bromo-4-hydroxybenzylidene)-3-(4-fluorophenyl)-2-thioxo-1,3-oxazolidin-4-one
Homo sapiens
-
cell-based assay, pH not specified in the publication, temperature not specified in the publication
0.000002
5-(3-bromo-4-hydroxybenzylidene)-3-(4-methylphenyl)-2-thioxo-1,3-oxazolidin-4-one
Homo sapiens
-
cell-based assay, pH not specified in the publication, temperature not specified in the publication
0.000002
5-(3-chloro-5-fluoro-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-thioxo-1,3-oxazolidin-4-one
Homo sapiens
-
cell-based assay, pH not specified in the publication, temperature not specified in the publication
0.000002
5-(3-fluoro-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-tioxo-1,3-oxazolidin-4-one
Homo sapiens
-
cell-based assay, pH not specified in the publication, temperature not specified in the publication
0.0019
5-bromo-2-[[(3-hydroxyphenyl)carbonyl]amino]benzoic acid
Homo sapiens
-
pH 7.0, temperature not specified in the publication
0.0022
5-chloro-2-[[(3-hydroxyphenyl)carbonyl]amino]benzoic acid
Homo sapiens
-
pH 7.0, temperature not specified in the publication
0.000001
5-[3,5-dichloro-4-(phosphonoxy)benzylidene]-3-(4-methoxyphenyl)-2-thioxo-1,3-oxazolidin-4-one
Homo sapiens
-
cell-based assay, pH not specified in the publication, temperature not specified in the publication
0.009 - 0.06698
7-hydroxyflavone
0.0093 - 0.18592
baicalein
0.0108
Biochanin A
Homo sapiens
-
IC50: 0.0108 mM, reduction of androstenedione
0.0233 - 0.0825
bis(2-butoxyethyl) phthalate
0.05
Cinnamic acid
Homo sapiens
-
IC50: 0.050 mM
0.0762
clomiphene
Homo sapiens
-
IC50: 0.0762 mM
0.000057
Cyclopropanecarboxylic acid ((3R,10S,13S)-3-hydroxy-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl)-octyl-amide
Homo sapiens
-
IC50: 57 nM
0.000085
Cyclopropanecarboxylic acid cyclohexylmethyl-((3R,10S,13S)-3-hydroxy-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl)-amide
Homo sapiens
-
IC50: 85 nM
0.0082 - 0.09
dicyclohexyl phthalate
0.000227
heptanoic acid (1-{1-[(3-hydroxy-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-ylmethyl)-carbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethyl)-amide
Homo sapiens
-
IC50: 227 nM
0.000035 - 0.000057
N-Adamantan-1-ylmethyl-N-((3R,10S,13S)-3-hydroxy-10,13-dimethyl-17-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl)-butyramide
Homo sapiens
-
IC50: 35-57 nM
0.0057
phenyl-p-benzoquinone
Homo sapiens
-
IC50: 0.0057 mM, reduction of androstenedione
0.000383
STX-2171
Homo sapiens
-
at 37°C
0.000201
STX-2622
Homo sapiens
-
at 37°C
0.000441
STX-2624
Homo sapiens
-
at 37°C
0.098
tamoxifen
Homo sapiens
-
IC50: 0.098 mM, time-dependent and irreversible
0.0014
umbelliferone