1.1.1.62: 17beta-estradiol 17-dehydrogenase

This is an abbreviated version, for detailed information about 17beta-estradiol 17-dehydrogenase, go to the full flat file.

Reaction

17beta-estradiol
+
NAD(P)+
=
estrone
+
NAD(P)H
+
H+

Synonyms

(17beta-HSD) type 1, (17beta-HSD) type 2, 17-beta-HSD 2, 17-beta-hydroxysteroid dehydrogenase type 12, 17-beta-hydroxysteroid dehydrogenase type 2, 17-HOR, 17-HSD, 17beta HSD1, 17beta,20alpha-hydroxysteroid dehydrogenase, 17beta-estradiol dehydrogenase, 17beta-HSD, 17beta-HSD I, 17beta-HSD type 1, 17beta-HSD type 12, 17beta-HSD type 2, 17beta-HSD type 4, 17beta-HSD type 5, 17beta-HSD type 7, 17beta-HSD type 8, 17beta-HSD1, 17beta-HSD12, 17beta-HSD2, 17beta-HSD4, 17beta-HSD5, 17beta-HSD7 2, 17beta-HSDcl, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 4, 17beta-hydroxysteroid dehydrogenase type 1, 17beta-hydroxysteroid dehydrogenase type 12, 17beta-hydroxysteroid dehydrogenase type 2, 17beta-hydroxysteroid dehydrogenase type 4, 17beta-hydroxysteroid dehydrogenase type 5, 17beta-hydroxysteroid dehydrogenase type 6, 17beta-hydroxysteroid dehydrogenase type 7, 17beta-hydroxysteroid dehydrogenase type 8, 17beta-hydroxysteroid dehydrogenase type I, 17beta-hydroxysteroid dehydrogenase types 1, 17beta-hydroxysteroid dehydrogenases type 1, 17betaHSD, 17betaHSD1, 17betaHSD14, 17betaHSD6, 17HSD1, 20 alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, 20alpha-hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-hydroxysteroid dehydrogenase, 3betaHSD, 7beta-HSD type 1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, dehydrogenase, estradiol 17beta-, E2DH, EDH, estradiol 17beta-dehydrogenase, estradiol dehydrogenase, estrogen 17-oxidoreductase, estrogenic 17beta-hydroxysteroid dehydrogenase, form 2 type 7 17beta-hydroxysteroid dehydrogenase, HSD17B1, HSD17B12, HSD17B2, HSD17B4, hydroxysteroid (17-beta) dehydrogenase 1, Ke6 protein, mf17beta-HSD12, microsomal 17-beta-hydroxysteroid dehydrogenase, More, oestradiol-17beta hydroxysteroid dehydrogenase, placental 17-beta-hydroxysteroid dehydrogenase, PRAP, PRL receptor associated protein, testicular 17-beta-hydroxysteroid dehydrogenase, type 1 17beta-HSD, type 1 17beta-hydroxysteroid dehydrogenase, type 12 17beta-HSD, type 12 17beta-hydroxysteroid dehydrogenase, type 7 17beta-hydroxysteroid dehydrogenase, type 8 17beta-HSD, type 8 17beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.62 17beta-estradiol 17-dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.62 - 17beta-estradiol 17-dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-indan-1-ol + NADP+
indan-1-one + NADPH
show the reaction diagram
-
-
-
?
1,2-dimethyl-6-dehydroestrone + NADH
1,2-dimethyl-6-dehydroestradiol + NAD+
show the reaction diagram
-
-
-
-
?
1,2-dimethylestradiol + NAD+
1,2-dimethylestrone + NADH
show the reaction diagram
-
-
-
-
r
1,2-dimethylestrone + NADH
1,2-dimethylestradiol + NAD+
show the reaction diagram
-
-
-
-
r
1,3-dimethyl-6-dehydroestrone + NADH
1,3-dimethyl-6-dehydroestradiol + NAD+
show the reaction diagram
-
-
-
-
?
1,4-diacetoxy-1,3,5(10)-estratrien-17-one + NADH
17beta-hydroxy-1,4-diacetoxy-1,3,5(10)-estratriene + NAD+
show the reaction diagram
-
-
-
-
?
1,4-dihydroxy-1,3,5(10)-estratrien-17-one + NADH
1,4,17-trihydroxy-1,3,5(10)-estratrien + NAD+
show the reaction diagram
-
-
-
-
?
1-methyl-6-dehydroestradiol + NAD+
1-methyl-6-dehydroestrone + NADH
show the reaction diagram
-
-
-
-
r
1-methyl-6-dehydroestrone + NADH
1-methyl-6-dehydroestradiol + NAD+
show the reaction diagram
-
-
-
-
r
1-methylestradiol + NAD+
1-methylestrone + NADH
show the reaction diagram
-
-
-
-
?
11-ketoequilenin acetate + NADH
17beta-hydroxy-11-ketoequilenin acetate + NAD+
show the reaction diagram
-
-
-
-
?
11alpha-hydroxyestradiol + NAD+
11alpha-hydroxyestrone + NADH
show the reaction diagram
-
-
-
-
?
11beta-hydroxyestradiol + NAD+
11beta-hydroxyestrone + NADH
show the reaction diagram
-
-
-
-
?
16-ketoestrone + NADH
16-ketoestradiol + NAD+
show the reaction diagram
-
-
-
-
?
17beta-estradiol + NADP+
estrone + NADPH
show the reaction diagram
17beta-hydroxyestra-4-en-3-one + NADP+
estra-4-en-3,17-dione + NADPH + H+
show the reaction diagram
-
-
-
-
r
18-nor-D-homoestrone 3-methyl ether + NADH
18-nor-D-homoestradiol 3-methyl ether + NAD+
show the reaction diagram
-
-
-
-
?
19-nortestosterone + NAD+
4-estren-3,17-dione + NADH
show the reaction diagram
-
2% of the activity with estradiol-17beta
-
-
?
2,4-dinitroestradiol + NAD+
2,4-dinitroestrone + NADH
show the reaction diagram
-
-
-
-
r
2,4-dinitroestrone + NADH
2,4-dinitroestradiol + NAD+
show the reaction diagram
-
-
-
-
r
2,4-dinitroestrone 3-oxyacetic acid ether + NADH
2,4-dinitroestradiol 3-oxyacetic acid ether + NAD+
show the reaction diagram
-
-
-
-
?
2,5(10)-estradiene-1,4,17-trione + NADH
17beta-hydroxy-2,5(10)-estradiene-1,4-dione + NAD+
show the reaction diagram
-
-
-
-
?
2-aminoestradiol + NAD+
2-aminoestrone + NADH
show the reaction diagram
-
-
-
-
?
2-methoxyestrone + NADH
2-methoxyestradiol + NAD+
show the reaction diagram
-
-
-
-
?
2-methylestradiol + NAD+
2-methylestrone + NADH
show the reaction diagram
-
-
-
-
?
2-nitroestradiol + NAD+
2-nitroestrone + NADH
show the reaction diagram
-
-
-
-
r
2-nitroestrone + NADH
2-nitroestradiol + NAD+
show the reaction diagram
-
-
-
-
r
2-nitroestrone 3-oxyacetic acid ester + NADH + H+
2-nitroestradiol-17beta-3-oxyacetic acid ester + NAD+
show the reaction diagram
-
-
-
-
?
20alpha-hydroxy-4-pregnen-3-one + NADP+
4-pregnen-3,20-dione + NADPH
show the reaction diagram
3-hydroxy-2,5(10)-estradiene-1,4,17-trione + NADH
3,17beta-dihydroxy-2,5(10)-estradiene-1,4-dione + NAD+
show the reaction diagram
-
-
-
-
?
3-methyl-O-estradiol + NAD(P)+
3-methyl-O-estrone + NAD(P)H
show the reaction diagram
-
-
-
-
?
3-O-methyl-17beta-estradiol + NAD+
3-O-methylestrone + NADH
show the reaction diagram
3beta-hydroxyandrost-5-en-17-one + NADPH
3beta,17beta-dihydroxyandrost-5-ene + NADP+
show the reaction diagram
-
i.e. dehydroepiandrosterone
-
-
?
4-aminoestrone + NADH
4-aminoestradiol + NAD+
show the reaction diagram
-
-
-
-
?
4-aminoestrone 3,4-diacetate + NADH
4-aminoestradiol 3,4-diacetate + NAD+
show the reaction diagram
-
-
-
-
?
4-androstene-3,17-dione + NADPH + H+
testosterone + NADP+
show the reaction diagram
4-androstenedione + NAD(P)H + H+
testosterone + NAD(P)+
show the reaction diagram
-
-
-
?
4-estrene-3,17-dione + NADH + H+
4-estrene-17beta-ol-3-one + NAD+
show the reaction diagram
-
-
-
r
4-estrene-3,17-dione + NADPH
4-estrene-17beta-ol-3-one + NADP+
show the reaction diagram
-
-
-
-
r
4-estrene-3,17-dione + NADPH + H+
4-estrene-17beta-ol-3-one + NADP+
show the reaction diagram
-
-
-
r
4-methyl-1,3,5(10)-estratriene-1,17beta-diol + NAD+
1-hydroxy-4-methyl-1,3,5(10)-estratriene-17-one + NADH
show the reaction diagram
-
-
-
-
?
4-nitrestrone + NADH
4-nitroestradiol + NAD+
show the reaction diagram
-
-
-
-
r
4-nitroestradiol + NAD+
4-nitroestrone + NADH
show the reaction diagram
-
-
-
-
r
5,7,9-estratrien-3beta-ol-17-one + NADH
5,7,9-estratriene-3beta,17beta-diol + NAD+
show the reaction diagram
-
-
-
-
?
5,7,9-estratriene-3beta,17beta-diol + NAD+
5,7,9-estratriene-3beta-ol-17-one + NADH
show the reaction diagram
-
-
-
-
?
5-androstene-3beta,17beta-diol + NAD+
5-androstene-3-beta-ol-17-one + NADH
show the reaction diagram
-
5.9% of the activity with estradiol
-
-
?
5-androstene-3beta-ol-17-one + NADPH
5-androstene-3beta,17beta-diol + NADP+
show the reaction diagram
-
-
-
?
5alpha-adrostane-3alpha,17beta-diol + NAD+
androsterone + NADH
show the reaction diagram
-
-
-
?
5alpha-androstane-3,17-dione + NADH + H+
5alpha-androstane-17beta-ol-3-one + NAD+
show the reaction diagram
-
-
-
r
5alpha-dihydrotestosterone + NAD+
5alpha-androstan-3,17-dione + NADH
show the reaction diagram
-
3.2% of the activity with estradiol
-
-
?
5alpha-dihydrotestosterone + NADH
5alpha-androstanedione + NAD+
show the reaction diagram
-
-
-
?
5alpha-dihydrotestosterone + NADP+
5alpha-androstan-3,17-dione + NADPH
show the reaction diagram
5alpha-dihydrotestosterone + NADPH
5alpha-androstane-3,17-dione + NADP+
show the reaction diagram
-
-
-
?
5alpha-dihydrotestosterone + NADPH + H+
5alpha-androstane-3beta,17beta-diol + 5alpha-androstane-3,17-dione + NADP+
show the reaction diagram
-
-
-
?
5beta-pregnan-20alpha-ol-3-one + NADPH
5beta-pregnane-3,20-dione + NADP+
show the reaction diagram
-
-
-
?
6-dehydroestrone 3-benzoate + NADH
6-dehydro-17beta-estradiol 3-benzoate + NAD+
show the reaction diagram
-
-
-
-
?
6-ketoestrone + NADH
6-ketoestradiol-17beta + NAD+
show the reaction diagram
-
-
-
-
?
6alpha,7alpha-dihydroxyestrone + NADH
6alpha,7alpha-dihydroxyestradiol + NAD+
show the reaction diagram
-
-
-
-
?
6alpha-hydroxyestradiol + NAD+
6alpha-hydroxyestrone + NADH
show the reaction diagram
-
-
-
-
?
7-ketoestrone + NADH
7-ketoestradiol-17beta + NAD+
show the reaction diagram
-
-
-
-
?
7alpha-hydroxyestradiol + NAD+
7alpha-hydroxyestrone + NADH
show the reaction diagram
-
-
-
-
?
7alpha-hydroxyestrone + NADH
7alpha-hydroxyestradiol + NAD+
show the reaction diagram
-
-
-
-
r
7beta-hydroxyestrone + NADH
7beta-hydroxyestradiol + NAD+
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
?
show the reaction diagram
-
-
-
-
?
androst-4-ene-3,17-dione + NADH + H+
testosterone + NAD+
show the reaction diagram
-
-
-
r
androst-4-ene-3,17-dione + NADPH
androst-4-ene-17beta-ol-3-one + NADP+
show the reaction diagram
-
-
-
-
-
androstenedione + NAD(P)H + H+
testosterone + NADP+
show the reaction diagram
-
-
-
?
androstenedione + NADPH + H+
testosterone + NADP+
show the reaction diagram
androsterone + NAD(P)H
5alpha-androstane-3alpha,17beta-diol + NAD(P)+ + H+
show the reaction diagram
-
-
-
?
benzene dihydrodiol + NADP+
catechol + NADPH
show the reaction diagram
-
-
-
?
dehydroepiandrosterone + NAD(P)H
5-androstene-3beta,17beta-diol + NAD(P)+
show the reaction diagram
-
-
-
?
dehydroepiandrosterone + NAD(P)H
androst-5-ene-3beta,17beta-diol + NAD(P)+
show the reaction diagram
-
-
-
-
?
dehydroepiandrosterone + NADP+
?
show the reaction diagram
-
-
-
-
?
dehydroepiandrosterone + NADPH + H+
5-androstene-3beta,17beta-diol + NADP+
show the reaction diagram
-
-
-
-
?
dihydrotestosterone + NAD(P)H + H+
androstane-3beta,17beta-diol + NAD(P)+
show the reaction diagram
-
-
-
-
?
dihydrotestosterone + NADPH + H+
5alpha-androstane-3beta,17beta-diol + NADP+
show the reaction diagram
-
-
-
-
?
DL-3-deoxyequilenin + NADH
17beta-hydroxy-DL-3-deoxyequilin + NAD+
show the reaction diagram
-
-
-
-
?
DL-6-methoxy-3-deoxy-equilenin + NAD+
17beta-hydroxy-DL-6-methoxy-3-deoxyequilenin + NAD+
show the reaction diagram
-
-
-
-
?
epitestosterone + NADP+
4-androsten-3,17-dione + NADPH + H+
show the reaction diagram
-
poor substrate
-
-
?
equilenin + NADH
17beta-hydroxyequilenin + NAD+
show the reaction diagram
-
-
-
-
?
equilin + NADH
17beta-hydroxyequilin + NAD+
show the reaction diagram
-
-
-
-
?
estradiol + NAD(P)+
estrone + NAD(P)H
show the reaction diagram
-
-
-
-
?
estradiol + NAD+
estrone + NADH + H+
show the reaction diagram
estradiol + NADP+
estrone + NADPH
show the reaction diagram
-
the equilibrium state is 92% estradiol to 8% estrone
-
-
?
estradiol + NADP+
estrone + NADPH + H+
show the reaction diagram
-
-
-
-
?
estradiol-17alpha + NADP+
estrone + NADPH
show the reaction diagram
-
at about 3% of the activity with estradiol-17beta
-
-
?
estradiol-17beta + NAD(P)+
estrone + NAD(P)H
show the reaction diagram
estradiol-17beta + NAD(P)+
estrone + NAD(P)H + H+
show the reaction diagram
estradiol-17beta + NAD+
estrone + NADH
show the reaction diagram
estradiol-17beta + NAD+
estrone + NADH + H+
show the reaction diagram
estradiol-17beta + NADP+
estrone + NADPH
show the reaction diagram
estradiol-17beta + NADP+
estrone + NADPH + H+
show the reaction diagram
estrone + NAD(P)H
estradiol + NAD(P)+
show the reaction diagram
estrone + NAD(P)H
estradiol-17beta + NAD(P)+
show the reaction diagram
estrone + NAD(P)H + H+
estradiol + NAD(P)+
show the reaction diagram
estrone + NAD(P)H + H+
estradiol-17beta + NAD(P)+
show the reaction diagram
estrone + NADH
estradiol-17beta + NAD+
show the reaction diagram
estrone + NADH + H+
estradiol + NAD+
show the reaction diagram
estrone + NADH + H+
estradiol-17beta + NAD+
show the reaction diagram
estrone + NADPH
17beta-estradiol + NADP+
show the reaction diagram
estrone + NADPH
estradiol + NADP+ + H+
show the reaction diagram
-
-
-
-
?
estrone + NADPH + H+
estradiol + NADP+
show the reaction diagram
-
-
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP
show the reaction diagram
-
-
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
show the reaction diagram
estrone 3-methyl ether + NADH
3-O-methyl-17beta-estradiol + NAD+
show the reaction diagram
-
-
-
-
?
estrone 3-oxyacetic acid ether + NADH
17beta-estradiol 3-O-oxyacetic acid ether + NAD+
show the reaction diagram
-
-
-
-
?
estronesulfate + NADPH
17beta-estradiolsulfate + NADP+
show the reaction diagram
-
-
-
-
r
pregn-4-en-20alpha-ol-3-one + NADP+
progesterone + NADPH
show the reaction diagram
-
-
-
?
progesterone + NADPH
? + NADP+
show the reaction diagram
-
low activity
-
-
?
S-tetralol + NADP+
?
show the reaction diagram
-
-
-
-
?
testosterone + NAD(P)+
4-androstene-3,17-dione + NAD(P)H
show the reaction diagram
-
17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues
-
-
?
testosterone + NAD+
4-androstene-3,17-dione + NADH
show the reaction diagram
testosterone + NADP+
4-androstene-3,17-dione + NADPH + H+
show the reaction diagram
zymosterone + NAD(P)H
zymosterol + NAD(P)+
show the reaction diagram
-
-
-
?
additional information
?
-