1.1.1.62: 17beta-estradiol 17-dehydrogenase

This is an abbreviated version, for detailed information about 17beta-estradiol 17-dehydrogenase, go to the full flat file.

Reaction

17beta-estradiol
+
NAD(P)+
=
estrone
+
NAD(P)H
+
H+

Synonyms

(17beta-HSD) type 1, (17beta-HSD) type 2, 17-beta-HSD 2, 17-beta-hydroxysteroid dehydrogenase type 12, 17-beta-hydroxysteroid dehydrogenase type 2, 17-HOR, 17-HSD, 17beta HSD1, 17beta,20alpha-hydroxysteroid dehydrogenase, 17beta-estradiol dehydrogenase, 17beta-HSD, 17beta-hsd 14, 17beta-HSD I, 17beta-HSD type 1, 17beta-HSD type 12, 17beta-HSD type 2, 17beta-HSD type 4, 17beta-HSD type 5, 17beta-HSD type 7, 17beta-HSD type 8, 17beta-HSD1, 17beta-HSD12, 17beta-HSD14, 17beta-HSD2, 17beta-HSD4, 17beta-HSD5, 17beta-HSD7 2, 17beta-HSDcl, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 1, 17beta-hydroxysteroid dehydrogenase 2, 17beta-hydroxysteroid dehydrogenase 4, 17beta-hydroxysteroid dehydrogenase type 1, 17beta-hydroxysteroid dehydrogenase type 12, 17beta-hydroxysteroid dehydrogenase type 14, 17beta-hydroxysteroid dehydrogenase type 2, 17beta-hydroxysteroid dehydrogenase type 4, 17beta-hydroxysteroid dehydrogenase type 5, 17beta-hydroxysteroid dehydrogenase type 6, 17beta-hydroxysteroid dehydrogenase type 7, 17beta-hydroxysteroid dehydrogenase type 8, 17beta-hydroxysteroid dehydrogenase type I, 17beta-hydroxysteroid dehydrogenase type IV, 17beta-hydroxysteroid dehydrogenase types 1, 17beta-hydroxysteroid dehydrogenases type 1, 17betaHSD, 17betaHSD1, 17betaHSD14, 17betaHSD6, 17HSD1, 20 alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, 20alpha-hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-hydroxysteroid dehydrogenase, 3betaHSD, 7beta-HSD type 1, AKR1B15, AKR1C1, AKR1C2, AKR1C3, AKR1C4, aldo-keto reductase 1B15, dehydrogenase, estradiol 17beta-, E2DH, EDH, estradiol 17beta-dehydrogenase, estradiol dehydrogenase, estrogen 17-oxidoreductase, estrogenic 17beta-hydroxysteroid dehydrogenase, form 2 type 7 17beta-hydroxysteroid dehydrogenase, HSD17B1, HSD17B12, HSD17B2, HSD17B4, hydroxysteroid (17-beta) dehydrogenase 1, Ke6 protein, mf17beta-HSD12, microsomal 17-beta-hydroxysteroid dehydrogenase, More, NlHsd17b12, oestradiol-17beta hydroxysteroid dehydrogenase, placental 17-beta-hydroxysteroid dehydrogenase, PRAP, PRL receptor associated protein, testicular 17-beta-hydroxysteroid dehydrogenase, type 1 17beta-HSD, type 1 17beta-hydroxysteroid dehydrogenase, type 12 17beta-HSD, type 12 17beta-hydroxysteroid dehydrogenase, type 7 17beta-hydroxysteroid dehydrogenase, type 8 17beta-HSD, type 8 17beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.62 17beta-estradiol 17-dehydrogenase

Source Tissue

Source Tissue on EC 1.1.1.62 - 17beta-estradiol 17-dehydrogenase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
17beta-HSD type 12 in 83% of the breast cancer specimen. The expression of 17beta-HSD type 12 is significantly higher in breast carcinoma specimen than in normal tissues; 17beta-HSD type 7 activity is detected in 47% of the breast cancer specimen; the 17beta-HSD type 1 can be detected only in one tumor
Manually annotated by BRENDA team
low mRNA expression
Manually annotated by BRENDA team
-
low level
Manually annotated by BRENDA team
no sex differences in enzyme expression
Manually annotated by BRENDA team
moderate expression
Manually annotated by BRENDA team
-
cultured cells, enzyme expression is stimulated with all-trans and 9-cis retinoic acid
Manually annotated by BRENDA team
; ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland
Manually annotated by BRENDA team
-
cultured cells, expresses 17beta-HSD isoforms 1-4
Manually annotated by BRENDA team
-
EpiskinTM is a cultured human epidermis. 17beta-hydroxysteroid dehydrogenase and 3alpha-hydroxysteroid dehdyrogenase activities are present at moderate levels in EpiskinTM, while 3beta-hydroxysteroid dehdyrogenase activity is low
Manually annotated by BRENDA team
-
ovarian surface epithelial cell
Manually annotated by BRENDA team
-
association of 17HSD1 with extravillous cells indicates that the enzyme perhaps plays a role in trophoblast invasion
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
epithelial cells. Increased expression of 17HSD1 in epithelial cells of fallopian tube may lead to a local estradiol supply sufficient for maintenance of tubal pregnancy
Manually annotated by BRENDA team
-
high expression
Manually annotated by BRENDA team
-
cultured cells, expresses 17beta-HSD isoforms 1-4
Manually annotated by BRENDA team
-
cultured cells, expresses 17beta-HSD isoforms 1-4
Manually annotated by BRENDA team
-
transfected with type 1 cDNA, high activity
Manually annotated by BRENDA team
no sex differences in enzyme expression
Manually annotated by BRENDA team
-
a T-lymphoma cell line
Manually annotated by BRENDA team
-
choriocarcinoma JAr cell
Manually annotated by BRENDA team
-
Jurkat acute T cell leukemia cell line
Manually annotated by BRENDA team
-
3beta- and 17beta-hydroxysteroid dehydrogenase are not altered in metyrapone-treated cells
Manually annotated by BRENDA team
-
cultured cells, expresses 17beta-HSD isoforms 1-4
Manually annotated by BRENDA team
high levels of 17betaHSD1 transcript are detected. Downregulation during follicular luteinization
Manually annotated by BRENDA team
moderate expression
Manually annotated by BRENDA team
-
cultured muscle cell
Manually annotated by BRENDA team
moderate expression
Manually annotated by BRENDA team
-
NSCLC, immunihostichemic enzyme analysis: higher 17betaHSD1 immunoreactivity tends to be positively associated with aromatase and tumor stage. A higher 17betaHSD1 immunoreactivity is also significantly associated with lower intratumoral estrone concentration and a higher intratumoral estradiol/estrone concentration ratio. On the other hand a higher 17betaHSD2 immunoreactivity is significantly associated with higher intratumoral estrone concentration
Manually annotated by BRENDA team
-
cultured cells
Manually annotated by BRENDA team
-
a B-lymphoma cell line
Manually annotated by BRENDA team
-
normal and tubal pregancies possess identical expression of 17HSD1 in syncytiotrophoblast cells and therefore, similar estradiol production in the placenta
Manually annotated by BRENDA team
-
breast cancer cell, 7beta-HSD type 1; breast cancer cell, 7beta-HSD type 1
Manually annotated by BRENDA team
isozyme AKR1B15.2
Manually annotated by BRENDA team
low mRNA expression
Manually annotated by BRENDA team
-
endometriotic epithelial cell line; endometriotic epithelial cell line
Manually annotated by BRENDA team
additional information