1.1.1.62: 17beta-estradiol 17-dehydrogenase

This is an abbreviated version, for detailed information about 17beta-estradiol 17-dehydrogenase, go to the full flat file.

Reaction

17beta-estradiol
+
NAD(P)+
=
estrone
+
NAD(P)H
+
H+

Synonyms

(17beta-HSD) type 1, (17beta-HSD) type 2, 17-beta-HSD 2, 17-beta-hydroxysteroid dehydrogenase type 12, 17-beta-hydroxysteroid dehydrogenase type 2, 17-HOR, 17-HSD, 17beta HSD1, 17beta,20alpha-hydroxysteroid dehydrogenase, 17beta-estradiol dehydrogenase, 17beta-HSD, 17beta-HSD I, 17beta-HSD type 1, 17beta-HSD type 12, 17beta-HSD type 2, 17beta-HSD type 4, 17beta-HSD type 5, 17beta-HSD type 7, 17beta-HSD type 8, 17beta-HSD1, 17beta-HSD12, 17beta-HSD2, 17beta-HSD4, 17beta-HSD5, 17beta-HSD7 2, 17beta-HSDcl, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 4, 17beta-hydroxysteroid dehydrogenase type 1, 17beta-hydroxysteroid dehydrogenase type 12, 17beta-hydroxysteroid dehydrogenase type 2, 17beta-hydroxysteroid dehydrogenase type 4, 17beta-hydroxysteroid dehydrogenase type 5, 17beta-hydroxysteroid dehydrogenase type 6, 17beta-hydroxysteroid dehydrogenase type 7, 17beta-hydroxysteroid dehydrogenase type 8, 17beta-hydroxysteroid dehydrogenase type I, 17beta-hydroxysteroid dehydrogenase types 1, 17beta-hydroxysteroid dehydrogenases type 1, 17betaHSD, 17betaHSD1, 17betaHSD14, 17betaHSD6, 17HSD1, 20 alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, 20alpha-hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-hydroxysteroid dehydrogenase, 3betaHSD, 7beta-HSD type 1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, dehydrogenase, estradiol 17beta-, E2DH, EDH, estradiol 17beta-dehydrogenase, estradiol dehydrogenase, estrogen 17-oxidoreductase, estrogenic 17beta-hydroxysteroid dehydrogenase, form 2 type 7 17beta-hydroxysteroid dehydrogenase, HSD17B1, HSD17B12, HSD17B2, HSD17B4, hydroxysteroid (17-beta) dehydrogenase 1, Ke6 protein, mf17beta-HSD12, microsomal 17-beta-hydroxysteroid dehydrogenase, More, oestradiol-17beta hydroxysteroid dehydrogenase, placental 17-beta-hydroxysteroid dehydrogenase, PRAP, PRL receptor associated protein, testicular 17-beta-hydroxysteroid dehydrogenase, type 1 17beta-HSD, type 1 17beta-hydroxysteroid dehydrogenase, type 12 17beta-HSD, type 12 17beta-hydroxysteroid dehydrogenase, type 7 17beta-hydroxysteroid dehydrogenase, type 8 17beta-HSD, type 8 17beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.62 17beta-estradiol 17-dehydrogenase

Source Tissue

Source Tissue on EC 1.1.1.62 - 17beta-estradiol 17-dehydrogenase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
retroperitonea, high mRNA expression
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
17beta-HSD type 12 in 83% of the breast cancer specimen. The expression of 17beta-HSD type 12 is significantly higher in breast carcinoma specimen than in normal tissues; 17beta-HSD type 7 activity is detected in 47% of the breast cancer specimen; the 17beta-HSD type 1 can be detected only in one tumor
Manually annotated by BRENDA team
low mRNA expression
Manually annotated by BRENDA team
-
low level
Manually annotated by BRENDA team
moderate expression
Manually annotated by BRENDA team
-
cultured cells, enzyme expression is stimulated with all-trans and 9-cis retinoic acid
Manually annotated by BRENDA team
ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland
Manually annotated by BRENDA team
-
cultured cells, expresses 17beta-HSD isoforms 1-4
Manually annotated by BRENDA team
-
EpiskinTM is a cultured human epidermis. 17beta-hydroxysteroid dehydrogenase and 3alpha-hydroxysteroid dehdyrogenase activities are present at moderate levels in EpiskinTM, while 3beta-hydroxysteroid dehdyrogenase activity is low
Manually annotated by BRENDA team
-
ovarian surface epithelial cell
Manually annotated by BRENDA team
-
association of 17HSD1 with extravillous cells indicates that the enzyme perhaps plays a role in trophoblast invasion
Manually annotated by BRENDA team
-
epithelial cells. Increased expression of 17HSD1 in epithelial cells of fallopian tube may lead to a local estradiol supply sufficient for maintenance of tubal pregnancy
Manually annotated by BRENDA team
-
high expression
Manually annotated by BRENDA team
-
cultured cells, expresses 17beta-HSD isoforms 1-4
Manually annotated by BRENDA team
-
cultured cells, expresses 17beta-HSD isoforms 1-4
Manually annotated by BRENDA team
-
transfected with type 1 cDNA, high activity
Manually annotated by BRENDA team
-
choriocarcinoma JAr cell
Manually annotated by BRENDA team
-
3beta- and 17beta-hydroxysteroid dehydrogenase are not altered in metyrapone-treated cells
Manually annotated by BRENDA team
-
cultured cells, expresses 17beta-HSD isoforms 1-4
Manually annotated by BRENDA team
high levels of 17betaHSD1 transcript are detected. Downregulation during follicular luteinization
Manually annotated by BRENDA team
moderate expression
Manually annotated by BRENDA team
-
cultured muscle cell
Manually annotated by BRENDA team
moderate expression
Manually annotated by BRENDA team
-
cultured cells
Manually annotated by BRENDA team
-
normal and tubal pregancies possess identical expression of 17HSD1 in syncytiotrophoblast cells and therefore, similar estradiol production in the placenta
Manually annotated by BRENDA team
-
breast cancer cell, 7beta-HSD type 1; breast cancer cell, 7beta-HSD type 1
Manually annotated by BRENDA team
low mRNA expression
Manually annotated by BRENDA team
low mRNA expression
Manually annotated by BRENDA team
-
endometriotic epithelial cell line; endometriotic epithelial cell line
Manually annotated by BRENDA team
additional information