1.1.1.62: 17beta-estradiol 17-dehydrogenase

This is an abbreviated version, for detailed information about 17beta-estradiol 17-dehydrogenase, go to the full flat file.

Reaction

17beta-estradiol
+
NAD(P)+
=
estrone
+
NAD(P)H
+
H+

Synonyms

(17beta-HSD) type 1, (17beta-HSD) type 2, 17-beta-HSD 2, 17-beta-hydroxysteroid dehydrogenase type 12, 17-beta-hydroxysteroid dehydrogenase type 2, 17-HOR, 17-HSD, 17beta HSD1, 17beta,20alpha-hydroxysteroid dehydrogenase, 17beta-estradiol dehydrogenase, 17beta-HSD, 17beta-HSD I, 17beta-HSD type 1, 17beta-HSD type 12, 17beta-HSD type 2, 17beta-HSD type 4, 17beta-HSD type 5, 17beta-HSD type 7, 17beta-HSD type 8, 17beta-HSD1, 17beta-HSD12, 17beta-HSD2, 17beta-HSD4, 17beta-HSD5, 17beta-HSD7 2, 17beta-HSDcl, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 4, 17beta-hydroxysteroid dehydrogenase type 1, 17beta-hydroxysteroid dehydrogenase type 12, 17beta-hydroxysteroid dehydrogenase type 2, 17beta-hydroxysteroid dehydrogenase type 4, 17beta-hydroxysteroid dehydrogenase type 5, 17beta-hydroxysteroid dehydrogenase type 6, 17beta-hydroxysteroid dehydrogenase type 7, 17beta-hydroxysteroid dehydrogenase type 8, 17beta-hydroxysteroid dehydrogenase type I, 17beta-hydroxysteroid dehydrogenase types 1, 17beta-hydroxysteroid dehydrogenases type 1, 17betaHSD, 17betaHSD1, 17betaHSD14, 17betaHSD6, 17HSD1, 20 alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, 20alpha-hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-hydroxysteroid dehydrogenase, 3betaHSD, 7beta-HSD type 1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, dehydrogenase, estradiol 17beta-, E2DH, EDH, estradiol 17beta-dehydrogenase, estradiol dehydrogenase, estrogen 17-oxidoreductase, estrogenic 17beta-hydroxysteroid dehydrogenase, form 2 type 7 17beta-hydroxysteroid dehydrogenase, HSD17B1, HSD17B12, HSD17B2, HSD17B4, hydroxysteroid (17-beta) dehydrogenase 1, Ke6 protein, mf17beta-HSD12, microsomal 17-beta-hydroxysteroid dehydrogenase, More, oestradiol-17beta hydroxysteroid dehydrogenase, placental 17-beta-hydroxysteroid dehydrogenase, PRAP, PRL receptor associated protein, testicular 17-beta-hydroxysteroid dehydrogenase, type 1 17beta-HSD, type 1 17beta-hydroxysteroid dehydrogenase, type 12 17beta-HSD, type 12 17beta-hydroxysteroid dehydrogenase, type 7 17beta-hydroxysteroid dehydrogenase, type 8 17beta-HSD, type 8 17beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.62 17beta-estradiol 17-dehydrogenase

Cloned

Cloned on EC 1.1.1.62 - 17beta-estradiol 17-dehydrogenase

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
chromosomal localizations of isozymes, DNA and amino acid sequence determination and analysis of isozymes 17beta-HSD1, 17beta-HSD3, 17beta-HSD4, overview
-
erxpression in Escherichia coli
-
expressed as GST-fusion proteins in Escherichia coli JM107 cells
expressed in Escherichia coli
-
expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells
-
expressed in HEK-293 cells by transient transfection
-
expressed in Sf9 insect cells
-
expression in Escherichia coli
expression in Escherichia coli as an enzymatically active His-tag fusion protein
-
expression in Spodoptera frugiperda Sf9 cells
-
expression of AKR1C3 in Eschericha coli
-
expression of GST-tagged wild-type and mutant enzymes in Escherichia coli strain JM107
-
HEK-293 cells stably expressing Macaca fascicularis type 12 17beta-HSD
HEK-293 cells transfected with human 17beta-HSD1-cDNA
-
HSD17B4 gene is located on the Z sex chromosome
-
MCF-7 cells stable transfected with an expression plasmid for human HSD17B1
-
the complete 17beta-HSD1 (HSD17B131) and 17beta-HSD12 (HSD17B12) cDNA sequences are cloned into the pCEP4 expression vector for expression in 293-EBNA cells
-
transgenic mouse lines universally overexpressing human HSD17B1 are generated and characterized at fetal and adult ages