1.1.1.60: 2-hydroxy-3-oxopropionate reductase

This is an abbreviated version, for detailed information about 2-hydroxy-3-oxopropionate reductase, go to the full flat file.

Reaction

D-glycerate
+
NAD(P)+
=
2-hydroxy-3-oxopropanoate
+
NAD(P)H
+
H+

Synonyms

beta-hydroxyacid dehydrogenase, GarR, More, tartronate semialdehyde reductase, TSAR, TSR, TSR1, UM02592

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.60 2-hydroxy-3-oxopropionate reductase

Crystallization

Crystallization on EC 1.1.1.60 - 2-hydroxy-3-oxopropionate reductase

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Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
enzyme with L-tartrate bound to the active site, sitting drop vapour diffusion method, mixing of 0.0005 ml of the protein solution, containing 107 mg/ml protein in in 10 mM HEPES pH 8.0, 200 mM NaCl, with 0.0005 ml of 0.1 M imidazole buffer pH 8.0, 1 M potassium/sodium L-tartrate and 0.2 M sodium chloride, and equilibrated at 16°C over 0.135 ml of this solution, overnight, X-ray diffraction structure determination and analysis at 1.65 A resolution, the single-wavelength anomalous diffraction method
-