1.1.1.54: allyl-alcohol dehydrogenase

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For detailed information about allyl-alcohol dehydrogenase, go to the full flat file.

Reaction

Synonyms

ADH1, allyl-ADH, NtRed-1

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.54 allyl-alcohol dehydrogenase

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Results	in table
248	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
6	Cofactor
1	General Information
9	Inhibitors
17	KM Value [mM]
2	Metals/Ions
8	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
7	Organism
1	Pathway
11	PDB ID
6	pH Optimum
1	pH Stability
1	Protein Variants
4	Purification (Commentary)
3	Reaction
2	Reaction Type
7	Reference
14	Specific Activity [micromol/min/mg]
1	Storage Stability
31	Substrates and Products (Substrate)
6	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Engineering

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Engineering on EC 1.1.1.54 - allyl-alcohol dehydrogenase

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additional information

Saccharomyces cerevisiae

isoform ADH1 oxidizes allyl alcohol to toxic acrolein. Use of the reaction to isolate mutations in the ADH1 gene that lead to decreased ADH activity. These yeast may grow more slowly due to slower reduction of acetaldehyde and a higher NADH/NAD+ ratio, which should decrease the oxidation of allyl alcohol

724009